Aurora Kinase Inhibitors: Current Status and Outlook.
London, United Kingdom. In Front Oncol, 2014
In humans, the Aurora kinase family consists of three members; Aurora-A, Aurora-B, and Aurora-C, which each share a conserved C-terminal catalytic domain but differ in their sub-cellular localization, substrate specificity, and function during mitosis.
Role of Aurora-A in Ovarian Cancer: A Meta-Analysis.
Guangzhou, China. In Oncol Res Treat, 2014
BACKGROUND: Recently, several studies have examined associations between Aurora-A expression and clinical outcome in patients with ovarian cancer, but yielded conflicting results with respect to survival.
Cyclin B2 and p53 control proper timing of centrosome separation.
Rochester, United States. In Nat Cell Biol, 2014
Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leading to anaphase bridges, and cyclin B2 triggering aurora-A-mediated Plk1 hyperactivation, resulting in accelerated centrosome separation and lagging chromosomes.
AURA 2: Empowering discovery of post-transcriptional networks.
Trento, Italy. In Translation (austin), 2013
To address this issue, we developed the second and vastly enhanced version of the Atlas of UTR Regulatory Activity (AURA 2), a meta-database centered on mapping interaction of trans-factors with human and mouse UTRs.