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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ectonucleotide pyrophosphatase/phosphodiesterase 2

ATX, Autotaxin, lysoPLD, ENPP2
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, phospholipase A2, CAN, V1a, Phosphodiesterase
Papers on ATX
Enteroendocrine cells are a potential source of serum autotaxin in men.
New
Oude Elferink et al., Amsterdam, Netherlands. In Biochim Biophys Acta, Feb 2016
UNASSIGNED: Objective Serum autotaxin (ATX) activity is significantly increased in cholestatic patients.
The Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
New
Watson et al., In J Med Chem, Feb 2016
UNASSIGNED: The Autotaxin-Lysophophatidic acid (ATX-LPA) signalling pathway is implicated in a variety of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic diseases, inflammation, neurodegeneration, and neuropathic pain, amongst others.
Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development.
New
CerĂ³n et al., La Rioja, Argentina. In Genetics, Feb 2016
interacting proteins needed for early cell divisions, such as SAO-1 and ATX-2, and also nuclear envelope proteins such as MEL-28.
Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
New
Miyasaka et al., Suita, Japan. In Int Immunol, Jan 2016
We previously showed that autotaxin (ATX), an enzyme that generates lysophosphatidic acid (LPA), is highly expressed in HEVs, and that the ATX/LPA axis plays an important role in the lymphocyte transmigration across HEVs.
Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.
New
Kershaw et al., Pittsburgh, United States. In Obesity (silver Spring), Dec 2015
OBJECTIVE: Autotaxin (ATX) is an adipocyte-derived lysophospholipase D that generates the lipid signaling molecule lysophosphatidic acid (LPA).
The autotaxin-lysophosphatidic acid pathway in pathogenesis of rheumatoid arthritis.
Review
New
Conde et al., Santiago de Compostela, Spain. In Eur J Pharmacol, Nov 2015
Lysophosphatidic acid (LPA) is a phospholipid that is mainly produced by the hydrolysis of lysophosphatidylcholine (LPC) by lysophospholipase D, which is also called autotaxin (ATX).
Multiple Mechanisms of Anti-Cancer Effects Exerted by Astaxanthin.
Review
New
Wang et al., Nanjing, China. In Mar Drugs, Jul 2015
Astaxanthin (ATX) is a xanthophyll carotenoid which has been approved by the United States Food and Drug Administration (USFDA) as food colorant in animal and fish feed.
Pathogenesis and Management of Pruritus in PBC and PSC.
Review
Beuers et al., In Dig Dis, 2014
The potent neuronal activator lysophosphatidic acid (LPA) and its forming enzyme, autotaxin (ATX), could be identified in the serum of patients with cholestatic pruritus.
Atomoxetine treatment in adults with attention-deficit/hyperactivity disorder.
Review
Day et al., Indianapolis, United States. In Postgrad Med, 2014
Atomoxetine (ATX), a nonstimulant, selective noradrenergic reuptake inhibitor, was approved in the United States in 2002 for the treatment of ADHD in children and adolescents, as well as adults.
Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.
Review
He et al., Rizhao, China. In Int J Clin Exp Med, 2014
LPA is generated from lysophosphatidylcholine by the extracellular enzyme, autotaxin (ATX).
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.
GeneRIF
Aidinis et al., Athens, Greece. In J Exp Med, 2012
Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.
Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice.
GeneRIF
Smyth et al., Lexington, United States. In Mol Endocrinol, 2012
Data suggest that ATX is a negative regulator of brown fat adipogenesis; inhibition of ATX promotes differentiation of brown adipocytes from cultured embryonic fibroblasts.
ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways.
GeneRIF
Zhang et al., Beijing, China. In Febs Lett, 2012
study found that LPS induces both ATX and LPA3 expression in THP-1 cells; the PKR and SPK1-mediated pathways are involved in both ATX and LPA3 induction, resulting in the coordinate up-regulation of these two genes
Autotaxin protects microglial cells against oxidative stress.
GeneRIF
Bourdon et al., Saint-Denis, Reunion. In Free Radic Biol Med, 2012
up-regulation of autotaxin expression in microglia could be a mechanism for protection against oxidative stress
Insights into autotaxin: how to produce and present a lipid mediator.
Impact
Perrakis et al., Netherlands. In Nat Rev Mol Cell Biol, 2011
Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic acid (LPA).
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
Impact
Hoppe et al., Hamburg, Germany. In Nat Cell Biol, 2011
Here we report a synergistic cooperation between CDC-48 and ATX-3 (the Caenorhabditis elegans orthologue of ataxin-3) in ubiquitin-mediated proteolysis and ageing regulation.
Stat3 mediates expression of autotaxin in breast cancer.
GeneRIF
Bromberg et al., New York City, United States. In Plos One, 2010
Activated Stat3 may regulate the migration of breast cancer cells through the regulation of ATX.
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases.
Impact
GeneRIF
Mills et al., Houston, United States. In Cancer Cell, 2009
ATX and LPA receptors can contribute to the initiation and progression of breast cancer.
Mammary tumorigenesis through LPA receptor signaling.
Impact
Moolenaar et al., Amsterdam, Netherlands. In Cancer Cell, 2009
Lysophosphatidic acid (LPA) is a lipid growth factor that is produced by an extracellular phospholipase, termed autotaxin (ATX), and acts via G protein-coupled receptors.
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs.
Impact
GeneRIF
Rosen et al., San Francisco, United States. In Nat Immunol, 2008
Facilitates the entry of lymphocytes from the blood into secondary lymphoid organs.
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