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Angiotensin II receptor-associated protein

ATRAP, AGTRAP, AT1 receptor-associated protein, angiotensin II type 1 receptor-associated protein
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Angiotensin II, AT1, Renin, V1a, AGE
Papers on ATRAP
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys.
New
Yamanishi et al., Hirakata, Japan. In Int J Mol Med, Sep 2015
Similar analyses of SHRSP-specific genes revealed that angiotensinogen (Agt), angiotensin II receptor-associated protein (Agtrap) and apolipoprotein H (Apoh) were possible candidate genes responsible for triggering strokes.
Angiotensin II type 1 receptor-associated protein plays a role in regulating the local renin-angiotensin system in HSC-T6 cells.
New
Hu et al., Guangzhou, China. In Mol Med Report, Sep 2015
The aim of the current study was to examine the expression of the angiotensin II type 1 receptor‑associated protein (ATRAP) in the rat hepatic stellate cell line HSC‑T6 and to determine its interactions with the local renin‑angiotensin system (RAS).
Renal tubule angiotensin II type 1 receptor-associated protein promotes natriuresis and inhibits salt-sensitive blood pressure elevation.
New
Umemura et al., Yokohama, Japan. In J Am Heart Assoc, Mar 2015
BACKGROUND: Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation.
Activation of the cardiac proteasome promotes angiotension II-induced hypertrophy by down-regulation of ATRAP.
New
Li et al., Fengzhen, China. In J Mol Cell Cardiol, Feb 2015
Mechanistically, these beneficial effects were associated with the inhibition of degradation of angiotensin II type 1 receptor-associated protein (ATRAP) and inactivation of AT1R-mediated p38 MAPK and STAT3 signaling pathways.
Angiotensin II Type 1 Receptor Binding Molecule ATRAP as a Possible Modulator of Renal Sodium Handling and Blood Pressure in Pathophysiology.
Review
Umemura et al., Yokohama, Japan. In Curr Med Chem, 2014
In the course of an investigational search for a means to functionally and selectively modulate AT1R signaling for that purpose, a molecule directly interacting with the carboxyl-terminal cytoplasmic domain of AT1R was identified by employing yeast two-hybrid screening of a mouse kidney cDNA library and named AT1R-associated protein (ATRAP).
Xuebijing attenuates hypotension through the upregulation of angiotensin II type 1 receptor-associated protein 1 in rats suffering from heat stroke.
Su et al., Guangzhou, China. In Int J Mol Med, 2014
The levels of Ang Ⅱ type 1 (AT1) receptor surface expression and AT1 receptor-associated protein 1 (Arap1) were decreased during HS; however, these effects were attenuated by pre-treatment with XBJ (shown by RT-qPCR and western blot analysis).
Deletion of the angiotensin II type 1 receptor-associated protein enhances renal sodium reabsorption and exacerbates angiotensin II-mediated hypertension.
Umemura et al., Yokohama, Japan. In Kidney Int, 2014
Angiotensin II type 1 receptor (AT1R)-associated protein (ATRAP) promotes AT1R internalization along with suppression of pathological activation of tissue AT1R signaling.
[Protective effects and mechanism of congguiyishen capsules on diabetic nephropathy rats].
Xia et al., In Zhong Yao Cai, 2014
After oral administration for 4 weeks, determined the 24 h urinary protein, Cr, kidney mass/body mass, FBG, Ang II, AT1R, AGTRAP and CTGF in the kidney.
Effects of Ang II receptor blocker irbesartan on adipose tissue function in mice with metabolic disorders.
Umemura et al., Yokohama, Japan. In Int J Med Sci, 2013
Furthermore irbesartan preserved the adipose gene expression of AT1R-associated protein (ATRAP), an endogenous inhibitory molecule of tissue AT1R signaling, with a concomitant tendency of up-regulation of adipose tissue ATRAP/AT1R ratio.
Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension.
Cai et al., College Station, United States. In Front Genet, 2013
These also included genes located in the GWAS loci such as AGTRAP-PLOD1 and CYP1A1-ULK3, which contain multiple potentially causative genes contributing to HTN susceptibility that need to be prioritized for study.
Effects of the Angiotensin receptor blocker olmesartan on adipocyte hypertrophy and function in mice with metabolic disorders.
Umemura et al., Yokohama, Japan. In Biomed Res Int, 2013
On the other hand, olmesartan exerted no evident influence on the adipose tissue expression of AT1R-associated protein (ATRAP), which is a molecule interacting with AT1R so as to inhibit pathological AT1R activation and is suggested to be an emerging molecular target in metabolic disorders with visceral obesity.
The physiology and pathophysiology of a novel angiotensin receptor-binding protein ATRAP/Agtrap.
Review
Umemura et al., Yokohama, Japan. In Curr Pharm Des, 2012
The Ang II type 1 receptor (AT1R)-associated protein (ATRAP/Agtrap) is a molecule specifically interacting with the carboxyl- terminal domain of AT1R.
Regulation of angiotensin II receptors beyond the classical pathway.
Review
Mogi et al., Japan. In Clin Sci (lond), 2012
ATRAP (AT(1)-receptor-associated protein) and ATIP (AT(2)-receptor-interacting protein) are well-characterized AngII-receptor-associated proteins.
14-3-3 protein and ATRAP bind to the soluble class IIB phosphatidylinositol transfer protein RdgBβ at distinct sites.
Review
Garner et al., London, United Kingdom. In Biochem Soc Trans, 2012
In addition to binding 14-3-3, the PITP domain of RdgBβ interacts with the Ang II (angiotensin II)-associated protein ATRAP (Ang II receptor-associated protein).
The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
GeneRIF
Cockcroft et al., London, United Kingdom. In Biochem J, 2011
The phosphatidylinositol transfer protein RdgBbeta binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock.
GeneRIF
Walley et al., Vancouver, Canada. In Crit Care Med, 2011
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats.
GeneRIF
Dechend et al., Berlin, Germany. In Hypertension, 2011
AT(1)-AB induces Ang II sensitivity. Our mechanistic study supports the existence of an "autoimmune-activating receptor" that could contribute to Ang II sensitivity and possible to preeclampsia.
Activation of skin renin-angiotensin system in diabetic rats.
GeneRIF
Yan et al., Guangzhou, China. In Endocrine, 2011
results suggest that the local renin-angiotensin system is activated in diabetic skin and Angiotensin II receptors type 1 and 2 are likely to mediate the pathological changes of diabetic skin
Angiotensin II and the vascular phenotype in hypertension.
Review
Touyz et al., Roma, Italy. In Expert Rev Mol Med, 2010
These receptors are regulated by the GPCR-interacting proteins ATRAP, ARAP1 and ATIP.
CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity.
GeneRIF
Kira et al., Fukuoka, Japan. In J Neurol Sci, 2010
CSF angiotensin II, ACE, and ACE2 levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 antibody, reflecting severe destruction of perivascular astrocytes
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