From the Editor's desk...: February 2016.
In J Hepatol, Feb 2016
In this work, Murillo et al. assessed the efficacy of gene therapy by transducing the liver of the Atp7b(-/-) WD mouse model with an adenovirus encoding the human ATP7B cDNA.
Signalling to eIF4E in cancer.
Montréal, Canada. In Biochem Soc Trans, Nov 2015
The activity of eIF4E is regulated at many levels, most profoundly by two major signalling pathways: PI3K (phosphoinositide 3-kinase)/Akt (also known and Protein Kinase B, PKB)/mTOR (mechanistic/mammalian target of rapamycin) and Ras (rat sarcoma)/MAPK (mitogen-activated protein kinase)/Mnk (MAPK-interacting kinases).
Wilson's disease and other neurological copper disorders.
Heidelberg, Germany. In Lancet Neurol, 2015
Direct genetic testing for ATP7B mutations are increasingly available to confirm the clinical diagnosis of Wilson's disease, and results from biochemical and genetic prevalence studies suggest that Wilson's disease might be much more common than previously estimated.