gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1

ATP6V1C1, ATP6C, ATP6V1C, V-ATPase c-subunit
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on ATP6V1C1
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
GeneRIF
Aguirre-Urízar et al., Santiago de Compostela, Spain. In Biotech Histochem, 2012
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts.
GeneRIF
Li et al., Linping, China. In Biochem J, 2009
Study demonstrates that Atp6v1c1 is an essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regulate F-actin ring formation in osteoclast activation.
Structural and functional characterization of two human V-ATPase subunit gene promoters.
GeneRIF
Kohno et al., Kitakyūshū, Japan. In Biochim Biophys Acta, 2003
proximal promoter region contains cis-acting elements required for expression in cancer cells
share on facebooktweetadd +1mail to friends