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ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2

ATP6V1B2, HO57, V-ATPase B2 subunit
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, V-ATPase, AGE, HAD, ATP6V0D2
Papers on ATP6V1B2
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
New
Impact
Fitzgibbon et al., Cambridge, United States. In Nat Genet, Jan 2016
More than half of the mutations preferentially co-occurred with mutations in ATP6V1B2 and ATP6AP1, which encode components of the vacuolar H(+)-ATP ATPase (V-ATPase) known to be necessary for amino acid-induced activation of mTORC1.
V-type ATPase proton pump expression during enamel formation.
Review
New
Paine et al., Los Angeles, United States. In Matrix Biol, Dec 2015
Western blot analyses, using specific antibodies to four of the V-type ATPase subunits (Atp6v0d2, Atp6v1b2, Atp6v1c1 and Atp6v1e1), were then applied to validate much of the qPCR data.
Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.
New
Impact
Kutsche et al., Hamburg, Germany. In Nat Genet, Jun 2015
We also identified a recurrent de novo missense change in ATP6V1B2, encoding the B2 subunit of the multimeric vacuolar H(+) ATPase, in two individuals with ZLS.
Proteome alterations in cortex of mice exposed to fluoride and lead.
New
Wang et al., China. In Biol Trace Elem Res, Mar 2015
Results showed that there were eight proteins in the cortex that significantly changed, whose biological functions were involved in (1) energy metabolism (Ndufs1, Atp5h, Atp6v1b2), (2) cytoskeleton (Spna2, Tuba1a, Tubb2a), (3) glycation repair (Hdhd2), and (4) cell stress response (Hspa8).
SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes.
Xu et al., Singapore, Singapore. In Plos One, 2014
Among them, ATP6V1B2, a subunit of the vacuolar (H+)-ATPase, was further shown to be associated with SIRT1 by co-immunoprecipitation assay.
Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer's disease-linked presenilin 1 A246E mutation can be reversed with cAMP.
Mitchell et al., Philadelphia, United States. In Neuroscience, 2014
PS1-fAD fibroblasts had increased expression of ATP6V1B2, ATG5, BECN1 TFEB mRNA, and of ATP6V1B2, ATG5 and beclin at the protein level, consistent with chronic impairment of autophagic and lysosomal functions in the mutant cells.
Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis.
Paine et al., Los Angeles, United States. In J Bone Miner Res, 2013
The mRNA expression of other endocytosis-related gene products is also upregulated during maturation including: lysosomal-associated membrane protein 1 (Lamp1); cluster of differentiation 63 and 68 (Cd63 and Cd68); ATPase, H(+) transporting, lysosomal V0 subunit D2 (Atp6v0d2); ATPase, H(+) transporting, lysosomal V1 subunit B2 (Atp6v1b2); chloride channel, voltage-sensitive 7 (Clcn7); and cathepsin K (Ctsk).
Gene expression profile and enrichment pathways in different stages of bladder cancer.
Ye et al., Chongqing, China. In Genet Mol Res, 2012
Six genes were down-regulated at the Ta-T1 stage, but were up-regulated at the T1-T2 stage (ANXA5, ATP6V1B2, CTGF, GEM, IL13RA1, and LCP1); 5 genes were up-regulated at the Ta-T1 stage, but down-regulated at the T1-T2 stage (ACPP, GNL1, RIPK1, RAPGEF3, and ZER1).
Bioinformatics analysis of proteomic profiles during the process of anti-Thy1 nephritis.
Chen et al., Beijing, China. In Mol Cell Proteomics, 2012
The expression patterns of ten DEPs, distributed across five clusters, including AKR1A1, AGAT, ATP6V1B2, HIBADH, MDH1, MPST, NIT2, PRDX6, PSMB7, and TPI1, were validated by Western blotting.
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
Hamilton et al., San Francisco, United States. In Mol Psychiatry, 2011
The strongest evidence for association in the meta-analysis was observed for intronic SNPs in ATP6V1B2 (P=6.78 x 10⁻⁷), SP4 (P=7.68 x 10⁻⁷) and GRM7 (P=1.11
Inhibition of osteoclast bone resorption by disrupting vacuolar H+-ATPase a3-B2 subunit interaction.
GeneRIF
Manolson et al., Toronto, Canada. In J Biol Chem, 2010
Disruption of vacuolar H+-ATPase a3-B2 subunit interaction inhibited osteoclast bone resorption.
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
GeneRIF
Turck et al., München, Germany. In J Psychiatr Res, 2010
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Role of CFTR and ClC-5 in modulating vacuolar H+-ATPase activity in kidney proximal tubule.
Malnic et al., São Paulo, Brazil. In Cell Physiol Biochem, 2009
siRNA-mediated CFTR channels and ClC-5 chloride-proton exchanger knockdown significantly reduced H(+)-ATPase activity and V-ATPase B2 subunit expression.
A comparative proteomics analysis of rat mitochondria from the cerebral cortex and hippocampus in response to antipsychotic medications.
Wan et al., Shanghai, China. In J Proteome Res, 2009
A total of 14 proteins, of which 6 belong to the respiratory electron transport chain (ETC) of oxidative phosphorylation (OXPHOS), showed significant changes in quantity including NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 (Ndufa10), NADH dehydrogenase (ubiquinone) flavoprotein 2 (Ndufv2), NADH dehydrogenase (ubiquinone) Fe-S protein 3 (Ndufs3), F1-ATPase beta subunit (Atp5b), ATPase, H+ transporting, lysosomal, beta 56/58 kDa, isoform 2 (Atp6v1b2) and ATPase, H+ transporting, V1 subunit A, isoform 1 (Atp6v1a1).
Extracellular pH change modulates the exon 7 splicing in SMN2 mRNA.
Chang et al., Kao-hsiung, Taiwan. In Mol Cell Neurosci, 2008
In addition, we tested whether intracellular pH-modulating genes could be the modifier of SMA in a SMA discordant family and found that the mRNA levels of ATP6V1B2 gene are significantly higher in two affected siblings than the unaffected one.
V-ATPase expression in the mouse olfactory epithelium.
Brown et al., United States. In Am J Physiol Cell Physiol, 2008
We also located both isoforms of the 56-kDa B subunit, ATP6V1B1 ("B1," typically expressed in epithelia specialized in regulated transepithelial proton transport) and ATP6V1B2 ("B2") in the OE.
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice.
GeneRIF
Brown et al., Boston, United States. In Am J Physiol Renal Physiol, 2007
the activity of apical B2-containing V-ATPase holoenzymes in A intercalated cells is sufficient to maintain baseline acid-base homeostasis
Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit.
GeneRIF
Breton et al., Boston, United States. In Am J Physiol Cell Physiol, 2007
Redistribution of Atp6v1b2 occurs from intracellular compartments into the apical membrane of epididymal clear cells from Atp6v1b1(-/-) mice.
Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis.
GeneRIF
Brown et al., United States. In Am J Physiol Cell Physiol, 2004
expressed in most, if not all, proton-secreting cells in the epithelium lining the nephron and the collecting ducts, and it is also present in proton-secreting clear cells of the epididymis
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