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ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D

Atp6m, ATP6V1D
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, p53, Spo11, Monoamine Oxidase, GPX2
Papers on Atp6m
Quantitative proteome of medulla oblongata in spontaneously hypertensive rats.
Lai et al., Guangzhou, China. In J Proteome Res, 2013
The differentially expressed proteins in the dysregulation of energy metabolism in the medulla of SHR rats included down-regulated ATP6V1D, ATP6VOA1, ATP5L, DLD proteins and up-regulated AK1 protein.
Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation.
Deschl et al., Kōbe, Japan. In Exp Toxicol Pathol, 2010
Gentamicin-induced lysosomal phospholipidosis was indicated by deregulation of lysosomal located gene products such as ATP6V1D, a subunit of the lysosomal H+ transporting ATPase.
Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.
Li et al., Vancouver, Canada. In Int J Oncol, 2008
Further analysis of this amplicon indicates that it encompassed genes involved in DNA repair (RAD51L, MLH3), reactive oxygen species (GPX2, CSTZ1, NGB, RDH11, ZADH1), and transportome (ABCD4, ATP6V1D, SLC10A6).
Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol.
Weiner et al., West Lafayette, United States. In Arch Biochem Biophys, 2002
Two of the identified proteins were the ATPase-related valosin-containing protein (VCP) and the lysosomal H(+)-transporting ATPase member M (ATP6M).
cDNA cloning, chromosomal localization and evolutionary analysis of mouse vacuolar ATPase subunit D, Atp6m.
Gumucio et al., Ann Arbor, United States. In Cytogenet Cell Genet, 2000
The mouse gene, designated Atp6m, maps to Chromosome 12, in a region of high homology with human chromosome 14q24.
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