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ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1

Atp5g1, ATPase subunit 9, F-ATPase subunit 9, ATP5A
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, ACID, CAN, HAD, POLYMERASE
Papers on Atp5g1
Povidone-Iodine (PVI) has a Profound Effect on in vitro Osteoblast Proliferation and Metabolic Function and Inhibits Their Ability to Mineralise and form Bone.
Jones et al., Salford, United Kingdom. In Spine (phila Pa 1976), Jan 2016
Protein expression of the electron transport chain subunits CII-SDHB, CIII-UQRCR2 and CV-ATP5A were measured via Western blotting.
Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.
Mook-Jung et al., Seoul, South Korea. In Hum Mol Genet, Dec 2015
Here, we found that ATP synthase subunit α (ATP5A) was O-GlcNAcylated at Thr432 and ATP5A O-GlcNAcylation was decreased in the brains of AD patients and transgenic mouse model, as well as Aβ-treated cells.
F1 -ATP synthase α subunit: a potential target for RNAi-mediated pest management of Locusta migratoria manilensis.
Xia et al., Chongqing, China. In Pest Manag Sci, Dec 2015
ATP synthase (F0 F1 -ATPase) uses proton- or sodium-motive force to produce 90% of the cellular ATP, and the α subunit of F1 -ATP synthase (ATP5A) is vital for F1 -ATP synthase.
Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma.
Koc et al., Huntington, United States. In Mitochondrion, Sep 2015
Western blot analyses of the several stage IVA HNSCC primary tumors have shown reduction in the expression of COII and ATP5A of the OXPHOS complexes IV and V subunits, respectively.
Liver-specific deletion of augmenter of liver regeneration accelerates development of steatohepatitis and hepatocellular carcinoma in mice.
Starzl et al., Pittsburgh, United States. In Gastroenterology, Feb 2015
Levels of carbamyl-palmitoyl transferase 1a and ATP synthase subunit ATP5G1 were reduced in livers of ALR-L-KO mice, indicating defects in mitochondrial fatty acid transport and ATP synthesis.
Gene expression profiles of entorhinal cortex in Alzheimer's disease.
He et al., Kaifeng, China. In Am J Alzheimers Dis Other Demen, 2014
Glycometabolism pathways network which was constructed by 4 glycometabolism pathways showed that adenosine triphosphate (ATP) synthase, H+transporting, mitochondrial F1 complex ATP5B, ATP5C1, ATP5D, and ATP5G1 had high degree related to ATP metabolism.
Biphasic response of mitochondrial biogenesis to oxidative stress in visceral fat of diet-induced obesity mice.
Liou et al., Kao-hsiung, Taiwan. In Antioxid Redox Signal, 2014
Until the 6th month, the VF had markedly increased mitochondrial DNA content and expression of PGC-1α, Tfam, ATP5A, and MnSOD.
Novel pathophysiological markers are revealed by iTRAQ-based quantitative clinical proteomics approach in vascular dementia.
Sze et al., Singapore, Singapore. In J Proteomics, 2014
Western blot analysis of selected proteins using samples from individual patients (n=10 per group) showed statistically significant increases in the abundance of SOD1 and NCAM and reduced ATP5A in VaD.
Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.
Grant et al., Philadelphia, United States. In Bmj Open Diabetes Res Care, 2013
When investigating all the known GWAS loci bound by TCF7L2 in the shortest gene list, derived from HCT116, the coronary artery disease-associated variant, rs46522 at the UBE2Z-GIP-ATP5G1-SNF8 locus, yielded significant association with T2D within DIAGRAM.
Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats.
Jin et al., Ottawa, Canada. In Plos One, 2013
In addition, NCM treatment increased cytochrome P450 2E1 protein expression and decreased ubiquinone pool, and mitochondrial ATP synthase subunit ATP5A and Complex IV activity.
Discovery of novel interacting partners of PSMD9, a proteasomal chaperone: Role of an Atypical and versatile PDZ-domain motif interaction and identification of putative functional modules.
Venkatraman et al., Mumbai, India. In Febs Open Bio, 2013
PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain.
Local translation of ATP synthase subunit 9 mRNA alters ATP levels and the production of ROS in the axon.
Kaplan et al., Bethesda, United States. In Mol Cell Neurosci, 2012
The siRNA-mediated knock-down of axonal ATP5G1 mRNA resulted in a significant reduction of axonal ATP5G1 protein and ATP levels. Silencing of local ATP5G1 expression enhanced the production of local reactive oxygen species.
Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import.
Manfredi et al., New York City, United States. In Mol Biol Cell, 2010
The subunit c isoforms are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein import, play a yet undiscovered role in respiratory chain maintenance.
Batten disease and mitochondrial pathways of proteolysis.
Dice et al., Boston, United States. In Biochem Mol Med, 1996
Because the F-ATPase subunit 9 accumulates within lysosomes of BD tissues, the degradative defect seemed likely to be within lysosomes.
MOM19, an import receptor for mitochondrial precursor proteins.
Neupert et al., München, Germany. In Cell, 1990
Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin, cytochrome c1, Fe/S protein, F0 ATPase subunit 9, and F1 ATPase subunit beta.
Mitochondrial protein import: nucleoside triphosphates are involved in conferring import-competence to precursors.
Neupert et al., In Cell, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit beta, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate reductase.
A mitochondrial reading frame which may code for a second form of ATPase subunit 9 in Aspergillus nidulans.
Davies et al., Manchester, United Kingdom. In Curr Genet, 1984
The derived amino acid sequence displays typical features of dicyclohexylcarbodiimide (DCCD) binding proteins and is 84% homologous with a mitochondrial reading frame that potentially encodes an ATPase subunit 9 polypeptide in Neurospora crassa.
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