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ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit

ATP5D
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the delta subunit of the catalytic core. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Actin, fibrillin-1, ACID, PGC
Papers on ATP5D
Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-α/PGC-1α signaling mediated energy biosynthesis.
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Zhang et al., Jinzhou, China. In Environ Toxicol Pharmacol, May 2015
Furthermore, APS increased the protein expressions of ATP5D, the σ subunit of ATP synthase, PGC-1α and pyruvate dehydrogenase kinase 4 (PDK4) in tissue and NRVMs respectively and inhibited the production of TNF-α in serum and culture medium compared with Iso alone.
ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury.
Han et al., Beijing, China. In Am J Physiol Heart Circ Physiol, 2015
Cardiac ischemia-reperfusion (I/R) injury remains a challenge for clinicians, which initiates with energy metabolism disorder.
Calpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL.
Song et al., Jinzhou, China. In Plos One, 2014
CAI also increased the activity of ATP synthase as well as protein expression of ATP5D, δ subunit of ATP synthase.
Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-κB/PGC-1α signaling mediated energy biosynthesis.
Wang et al., Jinzhou, China. In Plos One, 2014
Furthermore, ASIV increased the protein expression of ATP5D, subunit of ATP synthase and PGC-1α, inhibited translocation of p65, subunit of NF-κB into nuclear fraction in both rats and NRVMs compared with Iso alone.
Cardioprotection against ischemia/reperfusion injury by QiShenYiQi Pill® via ameliorate of multiple mitochondrial dysfunctions.
Fan et al., Tianjin, China. In Drug Des Devel Ther, 2014
Moreover, the impaired myocardial mitochondrial structure and function decreased level of ATP (accompanied by reduction of ATP5D and increase in the expression of cytochrome C).
Gene expression profiles of entorhinal cortex in Alzheimer's disease.
He et al., Kaifeng, China. In Am J Alzheimers Dis Other Demen, 2014
Glycometabolism pathways network which was constructed by 4 glycometabolism pathways showed that adenosine triphosphate (ATP) synthase, H+transporting, mitochondrial F1 complex ATP5B, ATP5C1, ATP5D, and ATP5G1 had high degree related to ATP metabolism.
Study of the effect of varicocelectomy on sperm proteins expression in patients with varicocele and poor sperm quality by using two-dimensional gel electrophoresis.
Gilani et al., Tehrān, Iran. In J Assist Reprod Genet, 2014
At the level of protein, a total of 3 protein spots were identified whose expression was significantly lower in sperm samples before varicocelectomy compared with after surgery including heat shock protein A5 (HSPA5), superoxide dismutase 1 (SOD1) and δ-subunit of the catalytic core of mitochondrial adenosine triphosphate synthase (ATP5D).
Protective effects of Notoginsenoside R1 on intestinal ischemia-reperfusion injury in rats.
Han et al., Beijing, China. In Am J Physiol Gastrointest Liver Physiol, 2014
Activation of nuclear factor-κB (NF-κB) and expression of ATP5D and tight junction proteins were determined by Western blotting.
Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms.
Han et al., Beijing, China. In Microcirculation, 2013
Content of ATP, ADP, and AMP in myocardium, cTnI level, expression of ATP5D, P-MLC2, and apoptosis-related molecules were determined.
QiShenYiQi Pills® prevent cardiac ischemia-reperfusion injury via energy modulation.
Han et al., Nanchang, China. In Int J Cardiol, 2013
ATP, ADP and AMP content was determined by Enzyme-Linked Immunosorbent Assay, F-actin in myocardial cells determined by immunofluorescence microscopy and expression of ATP synthase α, ATP5D, and phosphorylated-Myosin Light Chain (P-MLC) determined by western blotting.
Huang Qi Jian Zhong Pellet Attenuates TNBS-Induced Colitis in Rats via Mechanisms Involving Improvement of Energy Metabolism.
Han et al., Nanchang, China. In Evid Based Complement Alternat Med, 2012
In addition, ATP content and ATP5D expression in colonic mucosa decreased after TNBS challenge.
Breakpoint determination of 15 large deletions in Peutz-Jeghers subjects.
Ciccone et al., Bari, Italy. In Hum Genet, 2010
All our patients had a classical PJS phenotype, which shows that haploinsufficiency for SBNO2, C19orf26, ATP5D, MIDN, C19orf23, CIRBP, C19orf24,and EFNA2, does not apparently affect their clinical phenotype.
Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions.
Peters et al., Pittsburgh, United States. In Physiol Genomics, 2008
The expression levels of a number of functional categories of genes were reduced by shear stress including those encoding proteins involved in cell proliferation (CDC10, CDC20, CDC23, CCND1, CCNB1), angiogenesis (ANGPTL4, CTGF, CYR61, ENG, EPAS1, EGFR, LGALS3, PGK1, and SPARC), extracellular matrix and cell-matrix adhesion (EFEMP1, LOXL2, P4HB, FBN1, FN1, ITGA5, ITGAE, ITGAV, ILK, LAMR1) and ATP synthesis (ATP5G3, ATP5J2, ATP5L, ATP5D).
Proteomic analysis of lung adenocarcinoma: identification of a highly expressed set of proteins in tumors.
Beer et al., Ann Arbor, United States. In Clin Cancer Res, 2002
RESULTS: Antioxidant enzyme AOE372, ATP synthase subunit d (ATP5D), beta1,4-galactosyltransferase, cytosolic inorganic pyrophosphatase, glucose-regulated M(r) 58,000 protein, glutathione-S-transferase M4, prolyl 4-hydroxylase beta subunit, triosephosphate isomerase, and ubiquitin thiolesterase (UCHL1) were identified as being significantly overexpressed in lung adenocarcinomas.
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