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ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

Atp5b, mitochondrial ATP synthase beta subunit, ATPSB
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, GAPDH, CAN, ACID, ATPase
Papers on Atp5b
Examining the connectivity between different cellular processes in the Barrett tissue microenvironment.
O'Sullivan et al., Dublin, Ireland. In Cancer Lett, Jan 2016
The aim of this study was to examine the relationship between metabolism (ATP5B/GAPDH), hypoxia (HIF1α), inflammation (IL1β/SERPINA3), p53 and obesity status using in-vivo and ex-vivo models of Barrett oesophagus.
Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways.
Scott et al., Melbourne, Australia. In Oncotarget, Dec 2015
Global proteomic profiling of xenograft tumours (in presence of cetuximab, bevacizumab, and combination treatments) revealed alterations in proteins involved in glucose, lipid and fatty acid metabolism (e.g., GPD2, ATP5B, STAT3, FASN), as well as hypoxic regulators and vasculogenesis (e.g., ATP5B, THBS1, HSPG2).
ATP5A1 and ATP5B are highly expressed in glioblastoma tumor cells and endothelial cells of microvascular proliferation.
Li et al., North Bay Shore, United States. In J Neurooncol, Dec 2015
It was found that the mRNA levels of ATP5A1 and ATP5B in GBM tumor cells as well as microvascular proliferation were significantly higher compared with normal brain blood vessels.
Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring.
Kim et al., Seoul, South Korea. In Mol Cell Proteomics, Nov 2015
We determined that betaine-homocysteine S-methyltransferase 1, methylenetetrahydrofolate dehydrogenase 1, and ATP synthase subunit beta mitochondrial (ATP5B) expression levels were significantly reduced in the livers of rat offspring exposed to maternal food restriction during gestation compared with in the offspring of rats fed a normal diet (p < 0.05).
Effects of sialidase NEU1 siRNA on proliferation, apoptosis, and invasion in human ovarian cancer.
Gao et al., Shenzhen, China. In Mol Cell Biochem, Nov 2015
In addition, Western blot revealed that expressions of Cln3 and Cln5 were depressed, and ATP5B and ATP5J expressions were also reduced.
Proteomic study of pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome in rats.
Lin et al., Hong Kong, Hong Kong. In Chem Res Toxicol, Oct 2015
Subsequently, bioinformatic analysis suggested that two proteins, carbamoyl-phosphate synthase (CPS1) (p < 0.05) and ATP synthase subunit beta (ATP5B) (p < 0.01) were associated with RTS-L intoxication.
Differential expression profile of membrane proteins in L-02 cells exposed to trichloroethylene.
Liu et al., Shenzhen, China. In Toxicol Ind Health, Jul 2015
Furthermore, the differential expression of β subunit of adenosine triphosphate synthase (ATP5B) and prolyl 4-hydroxylase, β polypeptide (P4HB) were verified by Western blot analysis in TCE-treated L-02 cells.
Effects of mono(2-ethylhexyl)phthalate on cytoplasmic maturation of oocytes--The bovine model.
Roth et al., Israel. In Reprod Toxicol, Jun 2015
MEHP increased reactive oxygen species levels and reduced the proportion of highly polarized mitochondria along with alterations in genes associated with mitochondrial oxidative phosphorylation (CYC1, MT-CO1 and ATP5B).
[Investigation of trichloroethylene-induced effects on subcellular proteomes in L-02 hepatic cells].
Liu et al., Guangzhou, China. In Zhonghua Yu Fang Yi Xue Za Zhi, Mar 2015
The expression of ATP synthase subunit beta (ATP5B), heterogeneous nuclear ribonucleoprotein H2 (hnRNP H2) and far up steam element-binding protein 1 (FUBP1) were measured under TCE treatment by Western blot.
ATP5b and β2-microglobulin are predictive markers for the prognosis of patients with gallbladder cancer.
Chen et al., Changsha, China. In J Mol Histol, Feb 2015
This study investigates the clinical and pathological associations of ATP5B and β2M with benign and malignant lesions of the gallbladder.
ATP synthase subunit-β down-regulation aggravates diabetic nephropathy.
Liu et al., Taipei, Taiwan. In Sci Rep, 2014
In this study, we investigated the role of ATP synthase subunit-β (ATP5b) in diabetic nephropathy.
Potential therapeutic target for malignant paragangliomas: ATP synthase on the surface of paraganglioma cells.
Pacak et al., Bethesda, United States. In Am J Cancer Res, 2014
Here we show that ATP synthase β (ATP5B) is present on the cell surface of mouse pheochromocytoma cells as well as tumor cells of human SDHB-derived paragangliomas (PGLs), while being virtually absent on chromaffin primary cells from bovine adrenal medulla by confocal microscopy.
Identification of pivotal markers in vascular dementia based on proteomics data.
Duan et al., Harbin, China. In Dement Geriatr Cogn Disord, 2014
High-degree proteins were detected in the PPI network, such as ATP5B (ATP synthase subunit β).
Determining ACTB, ATP5B and RPL32 as optimal reference genes for quantitative RT-PCR studies of cryopreserved stallion semen.
Vega-Pla et al., Córdoba, Spain. In Anim Reprod Sci, 2014
Equine germplasm bank management involves not only the conservation and use of semen doses, in addition it can also be a resource to study stallion semen quality and after thawing semen properties for reproductive purposes.
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
International Headache Genetics Consortium et al., Cambridge, United Kingdom. In Nat Genet, 2013
Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
Ectopic ATP synthase facilitates transfer of HIV-1 from antigen-presenting cells to CD4(+) target cells.
Raviv et al., Bethesda, United States. In Blood, 2012
Ectopic ATP synthase could be an accessible molecular target for inhibiting HIV-1 proliferation in vivo.
Structural evidence of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria.
Walker et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
analysis of a new catalytic intermediate in the pathway of ATP hydrolysis by F1-ATPase from bovine heart mitochondria
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.
Jonas et al., New Haven, United States. In Nat Cell Biol, 2011
Increased mitochondrial energy metabolism efficiency via F1F0 ATPase synthase beta subunit contributes to the enhanced synaptic efficacy found in Bcl-x(L)-expressing neurons.
The calcium channel α2/δ1 subunit interacts with ATP5b in the plasma membrane of developing muscle cells.
García, Chicago, United States. In Am J Physiol Cell Physiol, 2011
association of calcium channel alpha2/delta subunit 1 and ATP5b occurs in intracellular membranes and at the plasma membrane of developing muscle cells, where they form a signaling complex capable of accelerating the rate of decline of calcium transients
Auto-antibodies to β-F1-ATPase and vimentin in malignant mesothelioma.
Robinson et al., Australia. In Plos One, 2010
Immunohistochemical analysis on a malignant mesothelioma tissue microarray showed cytoplasmic staining in 28 of 33 samples for vimentin and strong cytoplasmic staining in14 and weak in 16 samples for ss-F1-ATPase.
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