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ATPase, Na+/K+ transporting, beta 3 polypeptide

ATP1B3, CD298
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, fibrillin-1, V1a, OUT, CAN
Papers on ATP1B3
ATP1B3 Modulates the Restriction of HIV-1 Production and of NF-κB Activation by BST-2.
New
Takaku et al., Japan. In J Biol Chem, Jan 2016
UNASSIGNED: Here, we identify ATP1B3 and fibrillin-1 as novel BST-2-binding proteins.
A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.
New
Nickel et al., Heidelberg, Germany. In J Biol Chem, Mar 2015
As opposed to ATP1A1, down-regulation of the β1- and β3-chains (ATP1B1 and ATP1B3) of the Na/K-ATPase did not affect FGF2 secretion, suggesting that they are dispensable for this process.
Differential proteomic profiling in human spermatozoa that did or did not result in pregnancy via IVF and AID.
Zhou et al., Shanghai, China. In Proteomics Clin Appl, 2013
Using the results of bioinformatics analysis and Western Blotting, three proteins (A2LD1, ATP1B3 and FBXO2) were shown to have the same differential pattern (p<0.05) that was observed in the mass spectrometry analysis.
Identification and characterization of angiogenesis targets through proteomic profiling of endothelial cells in human cancer tissues.
Moore et al., Alameda, United States. In Plos One, 2012
The expression analyses of a panel of the identified targets were confirmed by immunohistochemistry (IHC) including CD146, B7H3, Thy-1 and ATP1B3.
Effect of dental amalgam on gene expression profiles in rat cerebrum, cerebellum, liver and kidney.
Yasutake et al., Japan. In J Toxicol Sci, 2011
Out of 26,962 rat genes, mercury vapor was found to increase the expression of 1 gene (Atp1b3) and decrease the expression of 1 gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in the cerebellum, increase the expression of 2 genes (Actb and Timm23) and decrease the expression of 1 gene (Spink3) in the liver, increase the expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6 genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.
GeneRIF
Mogil et al., Montréal, Canada. In Pain, 2009
These findings indicate that the beta3 subunit of the Na+,K+-ATPase is a novel determinant of nociceptive sensitivity and further supports the notion that pain variability genes have selective effects on individual pain modalities.(ATP1BETA3, MOUSE)
Muscle Na+-K+-ATPase activity and isoform adaptations to intense interval exercise and training in well-trained athletes.
GeneRIF
McKenna et al., Melbourne, Australia. In J Appl Physiol, 2007
Elevated Na+ -K+ -ATPase activity postexercise may contribute to reduced fatigue after training.
Differential expression profile prioritization of positional candidate glaucoma genes: the GLC1C locus.
Richards et al., Ann Arbor, United States. In Arch Ophthalmol, 2007
Two genes, ATP1B3 and COPB2, are of interest in the context of a protein-misfolding model for candidate selection.
Na, K ATPase beta3 subunit (CD298): association with alpha subunit and expression on peripheral blood cells.
GeneRIF
Kasinrerk et al., Chiang Mai, Thailand. In Tissue Antigens, 2006
These results evidenced that the beta3 subunit of Na, K ATPase is expressed on RBC membrane but the epitope recognized by mAb P-3E10 is hidden in normal RBCs. we showed the association of beta3 subunit and alpha subunit of Na, K ATPase.
Identification and expression analysis of genes associated with bovine blastocyst formation.
Peelman et al., Merelbeke, Belgium. In Bmc Dev Biol, 2006
The RNA expression profiles of 9 (75%) transcripts (KRT18, FN1, MYL6, ATP1B3, FTH1, HINT1, SLC25A5, ATP6V0B, RPL10) were in agreement with the subtractive cDNA cloning approach, whereas for the remaining 3 (25%) (ACTN1, COPE, EEF1A1) the RNA expression level was equal or even higher at the earlier developmental stages compared to the blastocyst stage.
Primary differentiation in the human blastocyst: comparative molecular portraits of inner cell mass and trophectoderm cells.
Lehrach et al., Berlin, Germany. In Stem Cells, 2005
Using a cDNA microarray composed of 15,529 cDNAs from known and novel genes, we identify marker transcripts specific to the ICM (e.g., OCT4/POU5F1, NANOG, HMGB1, and DPPA5) and TE (e.g., CDX2, ATP1B3, SFN, and IPL), in addition to novel ICM- and TE-specific expressed sequence tags.
Age-related changes in cyclic GMP and PKG-stimulated cerebellar Na,K-ATPase activity.
GeneRIF
Markus et al., São Paulo, Brazil. In Neurobiol Aging, 2005
Taken together, these data show that basal age-related decline in sodium pump activity is a consequence of changes in different steps of the cyclic GMP-PKG pathway.
[Study on the differentially expressed genes in bone tissue of ovariectomized rats after intervention with Chinese herbs].
Chen et al., Shanghai, China. In Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005
Among them, two were known proteins: hyaluronan-mediated motility receptor (RHAMM) and ATPase, Na+, K+ transporting beta 3 polypeptide (ATP1b3).
Training-induced changes in skeletal muscle Na+-K+ pump number and isoform expression in rats with chronic heart failure.
GeneRIF
Musch et al., Manhattan, United States. In J Appl Physiol, 2003
Chronic heart failure-induced alterations in skeletal muscle Na(+)-K(+)-ATPase, including B(max) and isoform expression, can be partially reversed by exercise training.
Absence of a significant linkage between Na(+),K(+)-ATPase subunit (ATP1A3 and ATP1B3) genotypes and bipolar affective disorder in the old-order Amish.
Gershenfeld et al., Iowa City, United States. In Am J Med Genet, 2001
This study examines the relationship between BPAD in the old-order Amish cohort and the Na(+),K(+)-ATPase alpha1 and beta3 subunit genes (ATP1A3, ATP1B3).
Structural organization and chromosomal localization of the human Na,K-ATPase beta 3 subunit gene and pseudogene.
Levenson et al., State College, United States. In Mamm Genome, 1998
We have cloned and characterized the Na,K-ATPase beta 3 subunit gene (ATP1B3), and a beta 3 subunit pseudogene (ATP1B3P1), from a human PAC genomic library.
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