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SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1

ATP-dependent helicase, SMARCAD1, HEL-1, Etl-1
This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] (from NCBI)
Top mentioned proteins: ATPase, POLYMERASE, ACID, HAD, CAN
Papers on ATP-dependent helicase
One-dimensional chiral copper (II) complexes with novel nano-structures and superior antitumor activity.
New
Lu et al., Beijing, China. In J Inorg Biochem, Feb 2016
The noncancerous cell lines (CCC-HEL-1) have showed that complexes 1-3 have hardly any cytotoxicity.
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
New
Eichenlaub-Ritter et al., Bielefeld, Germany. In Hum Reprod, Jan 2016
Denuded in vivo or in vitro matured MII oocytes were postovulatory aged and analyzed by semiquantitative confocal microscopy for abundance and localization of polyadenylated RNAs, proteins of maternal effect genes (transcription activator BRG1 also known as ATP-dependent helicase SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4) and NOD-like receptor family pyrin domain containing 5 (NLRP5) also known as MATER), RNA-binding proteins (MSY2 also known as germ cell-specific Y-box-binding protein, YBX2), and post-transcriptionally modified histones (trimethylated histone H3K9 and acetylated histone H4K12), as well as pericentromeric ATRX (alpha thalassemia/mental retardation syndrome X-linked, also termed ATP-dependent helicase ATRX or X-linked nuclear protein (XNP)).
Increased expression of ERCC2 gene in head and neck cancer is associated with aggressive tumors: a systematic review and case-control study.
New
Kayani et al., Islamabad, Pakistan. In Int J Biol Markers, Jan 2016
INTRODUCTION: The excision repair cross-complementation group 2 (ERCC2) ATP-dependent helicase is an essential member of the DNA repair pathway.
Genome-wide array-CGH analysis reveals YRF1 gene copy number variation that modulates genetic stability in distillery yeasts.
New
Wnuk et al., Rzeszów, Poland. In Oncotarget, Nov 2015
The losses of YRF1 genes (Y' element ATP-dependent helicase) were accompanied by decreased level of Y' sequences and an increase in DNA double and single strand breaks, and oxidative DNA damage in the S. paradoxus group compared to the S. bayanus group.
RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.
New
Lee et al., Taegu, South Korea. In Proc Natl Acad Sci U S A, Sep 2015
In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway.
Genome sequence of a novel endornavirus from the phytopathogenic fungus Alternaria brassicicola.
New
Zhu et al., Changsha, China. In Arch Virol, Jul 2015
Genome analysis revealed the presence of a single open reading frame coding for a polyprotein of 3400 aa containing conserved viral methyltransferase (MTR), viral RNA helicase 1 (Hel-1), and RNA-dependent RNA polymerase (RdRp) domains.
XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage.
New
Zhao et al., Beijing, China. In Nucleic Acids Res, Jul 2015
Xeroderma pigmentosum group D (XPD/ERCC2) encodes an ATP-dependent helicase that plays essential roles in both transcription and nucleotide excision repair of nuclear DNA, however, whether or not XPD exerts similar functions in mitochondria remains elusive.
Competing risks data analysis with high-dimensional covariates: an application in bladder cancer.
New
Mahjub et al., Hamadān, Iran. In Genomics Proteomics Bioinformatics, Jun 2015
Among them, expression of RTN4, SON, IGF1R, SNRPE, PTGR1, PLEK, and ETFDH was associated with a decrease in survival time, whereas SMARCAD1 expression was associated with an increase in survival time.
Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.
Rajender et al., Lucknow, India. In Plos One, 2014
Some transcripts were specific to the normozoospermic group (up-regulated: CAPNS1, FAM153C, ARF1, CFL1, RPL19, USP22; down-regulated: ZNF90, SMNDC1, c14orf126, HNRNPK), while some were specific to the asthenozoospermic group (up-regulated: RPL24, HNRNPM, RPL4, PRPF8, HTN3, RPL11, RPL28, RPS16, SLC25A3, C2orf24, RHOA, GDI2, NONO, PARK7; down-regulated: HNRNPC, SMARCAD1, RPS24, RPS24, RPS27A, KIFAP3).
The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.
Impact
GeneRIF
Llorente et al., Leiden, Netherlands. In Nature, 2012
findings unveil an evolutionarily conserved role for the Fun30 and SMARCAD1 chromatin remodellers in controlling end resection, homologous recombination and genome stability in the context of chromatin
Keeping chromatin quiet: how nucleosome remodeling restores heterochromatin after replication.
Review
Varga-Weisz et al., Cambridge, United Kingdom. In Cell Cycle, 2012
A new component of chromatin replication, the SWI/SNF-like chromatin remodeler SMARCAD1, acts at replication sites to facilitate deacetylation of newly assembled histones.
A mutation in a skin-specific isoform of SMARCAD1 causes autosomal-dominant adermatoglyphia.
GeneRIF
Sprecher et al., Tel Aviv-Yafo, Israel. In Am J Hum Genet, 2011
The existence of a short isoform of SMARCAD1 exclusively expressed in the skin, is demonstrated.
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.
GeneRIF
Mermoud et al., Cambridge, United Kingdom. In Mol Cell, 2011
Findings suggest that chromatin remodeling by SMARCAD1 ensures that silenced loci, such as pericentric heterochromatin, are correctly perpetuated.
The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging.
Review
Bryant-Greenwood et al., Honolulu, United States. In Hawaii Med J, 2011
WRN is an ATP-dependent helicase with 3' to 5' DNA exonuclease activity that regulates the replicative potential of dividing cells, and WRN loss-of-function mutations promote cellular senescence and neoplastic transformation.
The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS.
GeneRIF
Koga et al., Kisarazu, Japan. In J Mol Biol, 2008
Results suggest a novel model for gene regulation via the SMARCAD1/KIAA1122 protein complex.
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes.
Impact
Zamore et al., Worcester, United States. In Cell, 2005
An ATP-dependent helicase has been proposed first to separate the two siRNA strands, then the resulting single-stranded guide is thought to bind Ago2.
Papillomavirus E1 proteins: form, function, and features.
Review
Rangasamy et al., College Station, United States. In Virus Genes, 2002
In addition to ATP-dependent helicase activity, E1 proteins interact with and recruit several host cell replication proteins to viral origin, including DNA polymerase alpha and RPA.
SSL2, a suppressor of a stem-loop mutation in the HIS4 leader encodes the yeast homolog of human ERCC-3.
Impact
Donahue et al., Bloomington, United States. In Cell, 1992
The SSL2 gene encodes an essential 95 kd protein with ATP-dependent helicase motifs.
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