The functional and pathologic relevance of autophagy proteases.
In J Clin Invest, 2015
This process is coordinated by complex molecular systems, including the ATG8 ubiquitin-like conjugation system and the ATG4 cysteine proteases, which are implicated in the formation, elongation, and fusion of these autophagic vesicles.
Toxic metals and autophagy.
India. In Chem Res Toxicol, 2014
It is noted that metals/metalloids and nanoparticles prefer ATG8/LC3 as a potent inducer of autophagy in several cell lines or animal cells.
Regulation of autophagy: modulation of the size and number of autophagosomes.
Ann Arbor, United States. In Febs Lett, 2014
Specifically, we consider Ume6-ATG8 and Pho23-ATG9 transcriptional regulation in detail, as examples of how nuclear transcription factors and cytosolic machinery cooperate to determine autophagosome size and number, which are the two main mechanistic factors through which autophagy activity is regulated.
Network organization of the human autophagy system.
Boston, United States. In Nature, 2010
The six ATG8 orthologues in humans (MAP1LC3/GABARAP proteins) interact with a cohort of 67 proteins, with extensive binding partner overlap between family members, and frequent involvement of a conserved surface on ATG8 proteins known to interact with LC3-interacting regions in partner proteins.