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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Autophagy-related 7

Atg7, Apg7
This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vacuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes. [provided by RefSeq, Jan 2009] (from NCBI)
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Top mentioned proteins: Atg5, LC3, CAN, V1a, Beclin 1
Papers using Atg7 antibodies
Regulation of autophagy in mammals and its interplay with apoptosis
Boyano María D. et al., In Apoptosis, 2009
... Polyclonal rabbit anti-cleaved caspase-3 antibody and Atg7 rabbit monoclonal antibody were obtained from Cell Signaling Technology (Danvers, MA, USA) ...
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells.
Dryer Stuart E., In PLoS ONE, 2008
... Anti-LC3 was purchased from Novus Biologicals, LLC (Novus Biologicals, Littleton, CO, USA) and anti-Beclin 1, anti-Atg7 from Abcam.Ltd (Abcam, Cambridge, UK) ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... against microtubule-associated protein 1 light chain 3 (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell Signaling Technology, #2630), ATG7 (Cell Signaling Technology, #2631), phospho-mTOR (S2448) ...
Papers on Atg7
Intact endothelial autophagy is required to maintain vascular lipid homeostasis.
Finkel et al., Bethesda, United States. In Aging Cell, Feb 2016
Transient knockdown of the essential autophagy gene ATG7 resulted in higher levels of intracellular (125) I-LDL and oxidized LDL (OxLDL) accumulation, suggesting that in endothelial cells, autophagy may represent an important mechanism to regulate excess, exogenous lipids.
Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity.
Rudich et al., Beersheba, Israel. In Int J Obes (lond), Feb 2016
Similarly, decreased adiponectin and increased leptin secretion from cultured adipocytes stimulated with TNFα+IL-1β was partially reversed by siRNA-mediated knockdown of ATG7.
Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination.
Park et al., Pusan, South Korea. In Glia, Jan 2016
We found that the canonical formation of autophagolysosomes was induced in demyelinating Schwann cells after injury, and the inhibition of autophagy via Schwann cell-specific knockout of the atg7 gene or pharmacological intervention of lysosomal function caused a significant delay in myelin clearance.
Association of autophagy related gene polymorphisms with neutrophilic airway inflammation in adult asthma.
Park et al., Suwŏn, South Korea. In Korean J Intern Med, Jan 2016
In this study, we investigated the genetic association of ATG5 and ATG7 polymorphisms with asthma risk, severity and neutrophilic airway inflammation.
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Jan 2016
Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays.
Silvestrol induces early autophagy and apoptosis in human melanoma cells.
Burdette et al., Chicago, United States. In Bmc Cancer, Dec 2015
Silvestrol-mediated cell death was attenuated in ATG7-null mouse embryonic fibroblasts (MEFs) lacking a functional autophagy protein.
Dual Targeting of the Autophagic Regulatory Circuitry in Gliomas with Repurposed Drugs Elicits Cell-Lethal Autophagy and Therapeutic Benefit.
Hanahan et al., Lausanne, Switzerland. In Cancer Cell, Nov 2015
Efficacy of the combination was obviated by knockdown of the autophagic regulatory gene ATG7, implicating cell-lethal autophagy.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Murphy et al., Cambridge, United States. In Nat Cell Biol, 2014
By performing ubiquitin-affinity proteomics on PIK-III-treated cells we identified substrates including NCOA4, which accumulates in ATG7-deficient cells and co-localizes with autolysosomes.
Functions of autophagy in plant carbon and nitrogen metabolism.
Gong et al., Tianjin, China. In Front Plant Sci, 2013
Large-scale transcriptome analyses revealed that ATG8e belongs to a core carbon signaling response shared by Arabidopsis accessions, and the transcription of Arabidopsis ATG7 is tightly co-regulated with genes functioning in chlorophyll degradation and leaf senescence.
Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain.
Yue et al., New York City, United States. In J Neurosci, 2012
the results of this study suggested that disrupted autophagy(atg7 deficiency) may be associated with enhanced levels of endogenous alpha-syn and LRRK2 proteins
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.
Auberger et al., Nice, France. In Blood, 2012
Unexpected and essential role of autophagy during monocyte differentiation and acquisition of macrophage functions.
Atg7 modulates p53 activity to regulate cell cycle and survival during metabolic stress.
Finkel et al., Bethesda, United States. In Science, 2012
when nutrients are limited, Atg7 regulates p53-dependent cell cycle and cell death pathways
Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation.
Bouret et al., Los Angeles, United States. In Cell Metab, 2012
Lack of Atg7 in pro-opiomelanocortin neurons causes age-dependent accumulation of ubiquitin and p62 aggregates in the arcuate nucleus.
The end of autophagic cell death?
Kroemer et al., In Autophagy, 2012
Thus, knockdown of essential autophagy genes (such as ATG5 and ATG7) failed to prevent and rather accelerated chemotherapy-induced cell death, in spite of the fact that this manipulation efficiently inhibits autophagosome formation.
Lack of intestinal epithelial atg7 affects paneth cell granule formation but does not compromise immune homeostasis in the gut.
Becker et al., Erlangen, Germany. In Clin Dev Immunol, 2011
Lack of intestinal epithelial atg7 affected paneth cell granule formation but had no effect on susceptibility in a mouse model of experimentally induced colitis.
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.
Overholtzer et al., New York City, United States. In Nat Cell Biol, 2011
LC3 (Light chain 3) a component of autophagosomes, is recruited to single-membrane entotic vacuoles, macropinosomes and phagosomes harbouring apoptotic cells, in a manner dependent on the lipidation machinery including ATG5 and ATG7, and the class III phosphatidylinositol-3-kinase VPS34.
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Debnath et al., San Francisco, United States. In Cell, 2010
ATG12-ATG3 complex formation requires ATG7 as the E1 enzyme and ATG3 autocatalytic activity as the E2, resulting in the covalent linkage of ATG12 onto a single lysine on ATG3.
Autophagy and adipogenesis: implications in obesity and type II diabetes.
Jin et al., United States. In Autophagy, 2010
In this study, the role of autophagy in the differentiation of white adipose tissue was studied by deleting the autophagy-related 7 (atg7) gene from adipose tissue in mice.
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
Simmons et al., Oxford, United Kingdom. In Nat Med, 2010
This effect requires receptor-interacting serine-threonine kinase-2 (RIPK-2), autophagy-related protein-5 (ATG5), ATG7 and ATG16L1 but not NLR family, pyrin domain containing-3 (NALP3).We show that NOD2-mediated autophagy is required for both bacterial handling and generation of major histocompatibility complex (MHC) class II antigen-specific CD4(+) T cell responses in DCs.
Molecular mechanism of autophagy in yeast, Saccharomyces cerevisiae.
Ohsumi, Okazaki, Japan. In Philos Trans R Soc Lond B Biol Sci, 1999
We also found that apg7 and apg10 mutants were unable to form an Apg12p-Apg5p conjugate.
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