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ATG4 autophagy related 4 homolog C

Atg4C, autophagin-3
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Atg8, Atg3, LC3, Atg7, Atg4B
Papers on Atg4C
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin.
Tao et al., Suzhou, China. In Oncol Rep, Jul 2015
Real-time PCR revealed that cisplatin upregulated multiple autophagy-related genes, including AMBRA1, ATG3, ATG4C, ATG4D, ATG5, ATG7, ATG13, ATG14, ATG16L2, Beclin1, DRAM1, GABARAP, GABARAPL1, GABARAPL2, HDAC6, IRGM, MAP1LC3B and ULK1, indicating that cisplatin induced autophagy through a multiple mechanism involved manner.
Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
Hanley et al., Charlotte, United States. In Spine (phila Pa 1976), Jul 2015
Immunolocalization and ultrastructural studies for p62, ATG3, ATG4B, ATG4C, ATG7, L3A, ULK-2, and beclin were conducted.
Autophagy gene fingerprint in human ischemia and reperfusion.
Verma et al., Toronto, Canada. In J Thorac Cardiovasc Surg, 2014
Specifically, there were increases in the autophagy machinery components ATG4A, ATG4C, and ATG4D; tumor necrosis factor-related apoptosis-inducing ligand, MAPK8 and BCL2L1; and chaperone-mediated autophagy activity with increased heat shock protein (HSP) A8, HSP90AA1, and a-synuclein.
Investigating the Role of Gene-Gene Interactions in TB Susceptibility.
Hoal et al., Cape Town, South Africa. In Plos One, 2013
A number of models were successfully validated, indicating that interplay between the NRG1 - NRG3, GRIK1 - GRIK3 and IL23R - ATG4C gene pairs may modify susceptibility to TB. Gene pairs involved in the NF-κB pathway were also identified in the discovery data set (SFTPD - NOD2, ISG15 - TLR8 and NLRC5 - IL12RB1), but could not be tested in the Gambian study group due to lack of overlapping data.
MIR376A is a regulator of starvation-induced autophagy.
Gozuacik et al., İstanbul, Turkey. In Plos One, 2012
MIR376A shared the same seed sequence and had overlapping targets with MIR376B, and similarly blocked the expression of key autophagy proteins ATG4C and BECN1 (Beclin 1).
Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways.
Santoni et al., Macao. In J Leukoc Biol, 2012
we demonstrated for the first time that triggering of TRPV1 induces autophagy in mouse thymocytes resulting in AMPK activation and increased Atg4C mRNA expression
A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress.
Lane et al., Bristol, United Kingdom. In Autophagy, 2012
We have found that two Atg4 family members--Atg4C and Atg4D--contain cryptic mitochondrial targeting sequences immediately downstream of their canonical (DEVD) caspase cleavage sites.
miR-376b controls starvation and mTOR inhibition-related autophagy by targeting ATG4C and BECN1.
Gozuacik et al., İstanbul, Turkey. In Autophagy, 2012
miR-376b controls autophagy by directly regulating intracellular levels of two key autophagy proteins, ATG4C and BECN1.
The interplay between autophagy and ROS in tumorigenesis.
Karantza et al., United States. In Front Oncol, 2011
Subsequent studies demonstrated that Atg5(-/-) and Atg7(-/-) livers give rise to adenomas, Atg4C(-/-) mice are susceptible to chemical carcinogenesis, and Bif1(-/-) mice are prone to spontaneous tumors, indicating that autophagy defects promote tumorigenesis.
Polymorphisms in autophagy genes and susceptibility to tuberculosis.
van Crevel et al., Nijmegen, Netherlands. In Plos One, 2011
No association was found between TB and polymorphisms in the genes ATG10, ATG16L2, ATG2B, ATG5, ATG9B, IRGM, LAMP1, LAMP3, P2RX7, WIPI1, MTOR and ATG4C.
A genome-wide association study of aging.
Franceschini et al., Rotterdam, Netherlands. In Neurobiol Aging, 2011
These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease.
Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.
Yin et al., Indianapolis, United States. In J Biol Chem, 2011
The data indicated that Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A, whereas Atg4C and Atg4D had minimal activities as did the catalytic mutant of Atg4B (C74S).
The in vitro cleavage of the hAtg proteins by cell death proteases.
Bampton et al., Leicester, United Kingdom. In Autophagy, 2010
Cleavage of Beclin 1 was also seen in apoptosis of HeLa cells induced by staurosporine and TRAIL, along with cleavage of Atg3 and Atg4C.
Autophagy, proteases and the sense of balance.
López-Otín et al., Oviedo, Spain. In Autophagy, 2010
Our first approach to elucidate this question was based on the generation of autophagin-3/Atg4C-deficient mice, which, however, presented a minor phenotype.
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy.
Mayer et al., Tübingen, Germany. In Cancer Res, 2008
We found irradiation-induced accumulation of autophagosomes accompanied by strong mRNA induction of the autophagy-related genes beclin 1, atg3, atg4b, atg4c, atg5, and atg12 in each cell line.
Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3.
López-Otín et al., Oviedo, Spain. In J Biol Chem, 2007
Atg4C is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation
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