Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin.
Suzhou, China. In Oncol Rep, Jul 2015
Real-time PCR revealed that cisplatin upregulated multiple autophagy-related genes, including AMBRA1, ATG3, ATG4C, ATG4D, ATG5, ATG7, ATG13, ATG14, ATG16L2, Beclin1, DRAM1, GABARAP, GABARAPL1, GABARAPL2, HDAC6, IRGM, MAP1LC3B and ULK1, indicating that cisplatin induced autophagy through a multiple mechanism involved manner.
Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
Charlotte, United States. In Spine (phila Pa 1976), Jul 2015
Immunolocalization and ultrastructural studies for p62, ATG3, ATG4B, ATG4C, ATG7, L3A, ULK-2, and beclin were conducted.
Autophagy gene fingerprint in human ischemia and reperfusion.
Toronto, Canada. In J Thorac Cardiovasc Surg, 2014
Specifically, there were increases in the autophagy machinery components ATG4A, ATG4C, and ATG4D; tumor necrosis factor-related apoptosis-inducing ligand, MAPK8 and BCL2L1; and chaperone-mediated autophagy activity with increased heat shock protein (HSP) A8, HSP90AA1, and a-synuclein.
Investigating the Role of Gene-Gene Interactions in TB Susceptibility.
Cape Town, South Africa. In Plos One, 2013
A number of models were successfully validated, indicating that interplay between the NRG1 - NRG3, GRIK1 - GRIK3 and IL23R - ATG4C gene pairs may modify susceptibility to TB. Gene pairs involved in the NF-κB pathway were also identified in the discovery data set (SFTPD - NOD2, ISG15 - TLR8 and NLRC5 - IL12RB1), but could not be tested in the Gambian study group due to lack of overlapping data.
The interplay between autophagy and ROS in tumorigenesis.
United States. In Front Oncol, 2011
Subsequent studies demonstrated that Atg5(-/-) and Atg7(-/-) livers give rise to adenomas, Atg4C(-/-) mice are susceptible to chemical carcinogenesis, and Bif1(-/-) mice are prone to spontaneous tumors, indicating that autophagy defects promote tumorigenesis.
Polymorphisms in autophagy genes and susceptibility to tuberculosis.
Nijmegen, Netherlands. In Plos One, 2011
No association was found between TB and polymorphisms in the genes ATG10, ATG16L2, ATG2B, ATG5, ATG9B, IRGM, LAMP1, LAMP3, P2RX7, WIPI1, MTOR and ATG4C.
A genome-wide association study of aging.
Rotterdam, Netherlands. In Neurobiol Aging, 2011
These SNPs are in or near genes that are highly expressed in the brain (HECW2, HIP1, BIN2, GRIA1), genes involved in neural development and function (KCNQ4, LMO4, GRIA1, NETO1) and autophagy (ATG4C), and genes that are associated with risk of various diseases including cancer and Alzheimer's disease.
Autophagy, proteases and the sense of balance.
Oviedo, Spain. In Autophagy, 2010
Our first approach to elucidate this question was based on the generation of autophagin-3/Atg4C-deficient mice, which, however, presented a minor phenotype.