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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATG4 autophagy related 4 homolog B

Atg4B, autophagin-1, Apg4B
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LC3, Atg8, LC3B, Atg5, Ubiquitin
Papers using Atg4B antibodies
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
Yin Xiao-Ming et al., In Autophagy, 2007
... Anti-Flag was obtained from Sigma-Aldrich (F3165), anti-Atg4B was from Abgent (Ap1809c), anti-GAPDH was from ...
Papers on Atg4B
Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer.
Chen et al., Loudi, China. In Oncol Rep, Jan 2016
Furthermore, overexpression of miR-34a reduced the expression of autophagy-related proteins, ATG4B, Beclin-1 and LC3B II/I in PCa cells and demethylation treatment showed similar effect.
SLC27A4 regulate ATG4B activity and control reactions to chemotherapeutics-induced autophagy in human lung cancer cells.
Guo et al., Bozhou, China. In Tumour Biol, Jan 2016
ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes.
Avermectin induced autophagy in pigeon spleen tissues.
Li et al., Harbin, China. In Chem Biol Interact, Jan 2016
The expression of LC3, beclin-1, dynein, Atg4B and Atg5 increased, while mRNA levels of TORC1 and TORC2 were decreased in the AVM-treated groups relative to the control groups at 30, 60 and 90 days in the pigeon spleen.
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.
Turk et al., Ljubljana, Slovenia. In J Biol Chem, Dec 2015
tolerates a broad spectrum of amino acids in the P4 and P3 positions, similar to the human orthologue autophagin-1 (HsAtg4B).
Systems biology-based discovery of a potential Atg4B agonist (Flubendazole) that induces autophagy in breast cancer.
Liu et al., Chengdu, China. In Mol Biosyst, Nov 2015
The aim of this study was to explore the autophagy-related protein 4B(ATG4B) and its targeted candidate agonist in triple-negative breast cancer (TNBC) therapy.
A novel 2q37 microdeletion containing human neural progenitors genes including STK25 results in severe developmental delay, epilepsy, and microcephaly.
Carvalho et al., Boston, United States. In Am J Med Genet A, Nov 2015
The deleted segment contains genes that are highly expressed in the developing human cortical plate and the subventricular zone (SVZ) in vivo and human neural progenitors in vitro, including SEPT2, THAP4, ATG4B, PPP1R7, and STK25.
ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy.
Reed et al., Basel, Switzerland. In J Biol Chem, Nov 2015
LC3 is a substrate of the cysteine protease ATG4B (Autophagin-1), where cleavage generates a C-terminal glycine required for LC3 conjugation to lipids in autophagosomes.
Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B.
Young et al., Canada. In Bioorg Med Chem, Aug 2015
An efficient assay for monitoring the activity of the key autophagy-initiating enzyme ATG4B based on a small peptide substrate has been developed.
Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
Hanley et al., Charlotte, United States. In Spine (phila Pa 1976), Jul 2015
Immunolocalization and ultrastructural studies for p62, ATG3, ATG4B, ATG4C, ATG7, L3A, ULK-2, and beclin were conducted.
The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts.
Görlich et al., Göttingen, Germany. In Plos One, 2014
We now found that Xenopus laevis Atg4B (xAtg4B) is ideally suited for proteolytic removal of N-terminal tags from recombinant proteins.
MicroRNA-34a Suppresses Autophagy in Tubular Epithelial Cells in Acute Kidney Injury.
Xu et al., Nanchang, China. In Am J Nephrol, 2014
Moreover, miR-34a could directly bind to Atg4B 3'-untranslated region.
Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo.
Whitton et al., Los Angeles, United States. In Autophagy, 2014
Herein, using 3 recombinant CVB3s (rCVB3s) encoding different proteins (proLC3, proLC3(G120A), or ATG4B(C74A)), we show that CVB3 is, indeed, flexible in its utilization of cellular membranes.
In vitro assays of lipidation of Mammalian atg8 homologs.
Kominami et al., Tokyo, Japan. In Curr Protoc Cell Biol, 2013
The carboxyl termini of mammalian Atg8 homologs are cleaved by Atg4B, a cysteine protease, to expose carboxyl terminal Gly which is essential for this ubiquitylation-like reaction.
Autophagy proteins regulate the secretory component of osteoclastic bone resorption.
Virgin et al., Saint Louis, United States. In Dev Cell, 2011
The Atg4b participates in polarized secretion of lysosomal contents into the extracellular space by directing lysosomes to fuse with the plasma membrane.
Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.
Yin et al., Indianapolis, United States. In J Biol Chem, 2011
Atg4B possessed the broadest spectrum against all substrates, followed by Atg4A for ATG8 substrates
Histopathological and neurological features of Atg4b knockout mice.
Vogel et al., The Woodlands, United States. In Vet Pathol, 2011
Genetic inactivation of mouse Atg4b resulted in amorphous globular bodies in the neuropil of the deep cerebellar nuclei and adjacent vestibular nuclei and a mild but measurable impairment of motor performance on the Rotarod.
A balancing act for autophagin.
Subramani et al., San Diego, United States. In J Clin Invest, 2010
Mice lacking the protease autophagy-related 4B (Atg4b, also known as autophagin-1) exhibited a systemic reduction in autophagy and showed defects in the development of otoconia, organic particles that contain calcium carbonate crystals and proteins and that are essential for balance perception (equilibrioception) in mammals.
A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation.
Yamamoto et al., Ibaraki, Japan. In Nat Cell Biol, 2009
Overexpression of an Atg4B mutant, which causes defects in autophagosome formation, induces the accumulation of ER-IM complexes.
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.
Inagaki et al., Sapporo, Japan. In Embo J, 2009
The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 showed that, on LC3 binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes.
An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.
Yoshimori et al., Suita, Japan. In Mol Biol Cell, 2008
These results show that the lipidation of LC3 paralogues is involved in the completion of autophagosome formation in mammalian cells.
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