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ATG3 autophagy related 3 homolog

Atg3, Apg3, Aut1, Apg3p
Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole. Human ATG3 displays the same enzymatic characteristics in vitro as yeast Apg3, a protein-conjugating enzyme essential for autophagy (Tanida et al., 2002 [PubMed 11825910]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Atg7, Atg5, Atg12, LC3, Atg8
Papers on Atg3
AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism.
New
Cortés et al., Santiago, Chile. In Biochem Biophys Res Commun, Dec 2015
Before adipogenic differentiation, autophagy-related proteins (ATGs) ATG3, ATG5-ATG12 complex, ATG7 and LC3II were increased but autophagic flux was reduced, as suggested by increased p62 levels, in Agpat2(-/-) preadipocytes.
Inhibition of Autophagy Increases 2-Methoxyestradiol-Induced Cytotoxicity in SW1353 Chondrosarcoma Cells.
New
Maran et al., Salzburg, Austria. In J Cell Biochem, Oct 2015
Our results show that siRNAs directed against ATG3 blocks 2-ME-induced autophagosome formation in chondrosarcoma cells.
A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons.
New
Large et al., Verona, Italy. In J Pharmacol Exp Ther, Sep 2015
Here, we describe a novel small molecule, (5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione (AUT1), which modulates Kv3.1 and Kv3.2 channels in human recombinant and rodent native neurons.
Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes.
New
Otomo et al., Los Angeles, United States. In Biochem Biophys Res Commun, Aug 2015
Transfer of GABARAP thioester from the E1 ATG7 to the E2 ATG3 requires the interaction between the N-terminal domain of ATG7 and the flexible region (FR) of ATG3.
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin.
New
Tao et al., Suzhou, China. In Oncol Rep, Jul 2015
Real-time PCR revealed that cisplatin upregulated multiple autophagy-related genes, including AMBRA1, ATG3, ATG4C, ATG4D, ATG5, ATG7, ATG13, ATG14, ATG16L2, Beclin1, DRAM1, GABARAP, GABARAPL1, GABARAPL2, HDAC6, IRGM, MAP1LC3B and ULK1, indicating that cisplatin induced autophagy through a multiple mechanism involved manner.
Autophagy in the Degenerating Human Intervertebral Disc: In Vivo Molecular and Morphological Evidence, and Induction of Autophagy in Cultured Annulus Cells Exposed to Proinflammatory Cytokines-Implications for Disc Degeneration.
New
Hanley et al., Charlotte, United States. In Spine (phila Pa 1976), Jul 2015
Immunolocalization and ultrastructural studies for p62, ATG3, ATG4B, ATG4C, ATG7, L3A, ULK-2, and beclin were conducted.
miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia.
New
Lee et al., Seoul, South Korea. In Exp Neurobiol, Jun 2015
Overexpression of miR-Let7A in LPS-stimulated BV2 microglial cells promoted the induction of the autophagy related factors such as LC3II, Beclin1, and ATG3.
ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function.
New
Impact
Debnath et al., San Francisco, United States. In Nat Cell Biol, Mar 2015
Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target.
Novel adjuvants from seaweed impede autophagy signaling in therapy-resistant residual pancreatic cancer.
Aravindan et al., India. In J Biomed Sci, 2014
The cells were subjected to QPCR to examine transcriptional alterations in the following autophagy functional regulators: ATG3, ATG5, ATG7, ATG12, LC3A, LC3B, Beclin, Myd88, HMGB1, Rage, and TLRs 1-9.
ATG12-ATG3 connects basal autophagy and late endosome function.
Review
Debnath et al., San Francisco, United States. In Autophagy, 2014
We recently identified a novel interaction between the ATG12-ATG3 conjugate and the ESCRT-associated protein PDCD6IP/Alix that promotes basal autophagy and endolysosomal trafficking.
Induction of autophagy markers is associated with attenuation of miR-133a in diabetic heart failure patients undergoing mechanical unloading.
Mishra et al., Omaha, United States. In Am J Transl Res, 2014
Four ND with highly upregulated and 5 D with highly downregulated miR-133a were analyzed for autophagy markers (Beclin1, LC3B, ATG3) and their upstream regulators (mTOR and AMPK), and hypertrophy marker (beta-myosin heavy chain) by RT-qPCR, Western blotting and immunofluorescence.
Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells.
Rosen et al., Halifax, Canada. In Autophagy, 2014
In an effort to identify the mechanisms of detachment-induced autophagy and growth arrest of nonmalignant cells we found here that detachment of these cells causes upregulation of ATG3 and that ATG3 upregulation contributes to autophagy and growth arrest of detached cells.
Structural insights into E2-E3 interaction for LC3 lipidation.
Review
Otomo et al., Los Angeles, United States. In Autophagy, 2014
At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE).
Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death.
GeneRIF
Gozuacik et al., İstanbul, Turkey. In Apoptosis, 2012
caspase-8 overexpression led to Atg3 degradation and this event depended on caspase-8 enzymatic activity
Function and molecular mechanism of acetylation in autophagy regulation.
Impact
GeneRIF
Yu et al., Beijing, China. In Science, 2012
identified Esa1 as a histone acetyltransferase required for autophagy; identified Atg3 as a substrate for Esa1; acetylation of K19 and K48 of Atg3 regulated autophagy by controlling Atg3 and Atg8 interaction and lipidation of Atg8
Vaccinia virus leads to ATG12–ATG3 conjugation and deficiency in autophagosome formation.
GeneRIF
Jin et al., United States. In Autophagy, 2011
Vaccinia virus actively disrupts the cellular autophagy through a novel molecular mechanism that is associated with aberrant LC3 lipidation and a direct conjugation between ATG12 and ATG3.
Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway.
GeneRIF
Schulman et al., Memphis, United States. In Mol Cell, 2011
The model and biochemical data provide a rationale for Atg7 dimerization: Atg8 is transferred in trans from the catalytic cysteine of one Atg7 protomer to Atg3 bound to the N-terminal domain of the opposite Atg7 protomer within the homodimer.
ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.
Impact
GeneRIF
Debnath et al., San Francisco, United States. In Cell, 2010
These results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation.
Autophagy regulates programmed cell death during the plant innate immune response.
Impact
Dinesh-Kumar et al., New Haven, United States. In Cell, 2005
The restriction of HR PCD also requires orthologs of other autophagy-related genes including PI3K/VPS34, ATG3, and ATG7.
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