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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATG16 autophagy related 16-like 1

ATG16L1, Atg16L
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: NOD2, IL23R, IBD, LC3, CAN
Papers using ATG16L1 antibodies
Aging: past, present and future
Supplier
Lisanti Michael P. et al., In Cell Cycle, 2008
... (Abcam, #ab10433); Cathepsin B (FL-339) (Santa Cruz, #sc-13985); Lamp-1 (E-5) (Santa Cruz, #sc-17768); LC3 (Abcam, ab48395); ATG16L1 (Abgent, #AP1817a); p21 (H-164) (Santa ...
Papers on ATG16L1
Punicalagin promotes autophagy to protect primary human syncytiotrophoblasts from apoptosis.
New
Nelson et al., Shanghai, China. In Reproduction, Feb 2016
The apoptosis-reducing effect of punicalagin was attenuated by inhibition of autophagy using bafilomycin or knockdown of the autophagy related gene, ATG16L1.
Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation.
New
Virgin et al., Saint Louis, United States. In Cell Host Microbe, Feb 2016
Using a lysozyme-M-cre (LysMcre) expression system, we show that deletion of autophagy-related (Atg) genes Fip200, beclin 1, Atg14, Atg16l1, Atg7, Atg3, and Atg5, in the myeloid compartment, inhibited MHV68 reactivation in macrophages.
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
New
Impact
Stallings et al., Saint Louis, United States. In Nature, Jan 2016
The involvement of autophagy has been defined based on studies in cultured cells where M. tuberculosis co-localizes with autophagy factors ATG5, ATG12, ATG16L1, p62, NDP52, BECN1 and LC3 (refs 2-6), stimulation of autophagy increases bacterial killing, and inhibition of autophagy increases bacterial survival.
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
New
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Jan 2016
Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays.
Dysbiotic gut microbiome: A key element of Crohn's disease.
Review
New
Sipos et al., Budapest, Hungary. In Comp Immunol Microbiol Infect Dis, Dec 2015
The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology.
Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease.
Review
New
Monteleone et al., Roma, Italy. In Clin Sci (lond), Dec 2015
CARD15 (caspase-activating recruitment domain 15) and ATG16L1 (autophagy-related 16-like 1)] are associated with this phenotype, and experimental evidence suggests that intestinal fibrosis results from an altered balance between deposition of ECM (extracellular matrix) and degradation of ECM by proteases.
Genetics of inflammatory bowel disease from multifactorial to monogenic forms.
Review
New
Tommasini et al., Trieste, Italy. In World J Gastroenterol, Dec 2015
Some IBD associated genes are involved in innate immunity, in the autophagy and in the inflammatory response such as NOD2, ATG16L1 and IL23R, while other are implicated in immune mediated disease (STAT3) and in susceptibility to mycobacterium infection (IL12B).
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
New
Impact
IBD Genetics Consortium et al., Groningen, Netherlands. In Nat Genet, Sep 2015
Nevertheless, we observe genetic heterogeneity between divergent populations at several established risk loci driven by differences in allele frequency (NOD2) or effect size (TNFSF15 and ATG16L1) or a combination of these factors (IL23R and IRGM).
ATG16L1: A multifunctional susceptibility factor in Crohn disease.
Review
New
Nielsen et al., Copenhagen, Denmark. In Autophagy, May 2015
Of interest, single-nucleotide polymorphisms in ATG16L1 (autophagy-related 16-like 1 [S.
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach.
Ancuta et al., Montréal, Canada. In Retrovirology, 2014
A meta-analysis using the NCBI HIV Interaction Database revealed a set of Th17-specific HIV dependency factors (HDFs): PARG, PAK2, KLF2, ITGB7, PTEN, ATG16L1, Alix/AIP1/PDCD6IP, LGALS3, JAK1, TRIM8, MALT1, FOXO3, ARNTL/BMAL1, ABCB1/MDR1, TNFSF13B/BAFF, and CDKN1B.
Mechanisms of Microbe-Host Interaction in Crohn's Disease: Dysbiosis vs. Pathobiont Selection.
Review
Haller et al., Freising, Germany. In Front Immunol, 2014
New hypothesis-driven mouse models, e.g., epithelial-specific Caspase8(-/-), ATG16L1(-/-), and XBP1(-/-) mice, validate pathway-focused function of specific CD-associated risk genes highlighting the role of Paneth cells in antimicrobial defense.
Impact of T300A Variant of ATG16L1 on Antibacterial Response, Risk of Culture Positive Infections, and Clinical Course of Crohn's Disease.
Seidelin et al., Copenhagen, Denmark. In Clin Transl Gastroenterol, 2014
OBJECTIVES: Autophagy-related 16-like 1 (ATG16L1) deficiency leads to impaired cellular autophagy and bacterial degradation as well as an altered cytokine production.
Autophagy gene Atg16L1 prevents lethal T cell alloreactivity mediated by dendritic cells.
Impact
Cadwell et al., New York City, United States. In Immunity, 2014
Atg16L1 mediates the cellular degradative process of autophagy and is considered a critical regulator of inflammation based on its genetic association with inflammatory bowel disease.
The parasitophorous vacuole membrane of Toxoplasma gondii is targeted for disruption by ubiquitin-like conjugation systems of autophagy.
Impact
Virgin et al., Chicago, United States. In Immunity, 2014
Here we show that the cassette of autophagy proteins involved in the conjugation of microtubule-associated protein 1 light chain 3 (LC3) to phosphatidylethanolamine, including Atg7, Atg3, and the Atg12-Atg5-Atg16L1 complex play crucial roles in the control of T. gondii in vitro and in vivo.
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Impact
van Lookeren Campagne et al., San Francisco, United States. In Nature, 2014
A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease.
Atg16L1 deficiency confers protection from uropathogenic Escherichia coli infection in vivo.
GeneRIF
Mysorekar et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2012
Atg16L1 deficiency confers protection in vivo to the host against both acute and latent uropathic Escherichia coli infection.
The effect of the ATG16L1 Thr300Ala polymorphism on susceptibility and outcome of patients with epithelial cell-derived thyroid carcinoma.
GeneRIF
Netea-Maier et al., In Endocr Relat Cancer, 2012
The 300Ala (G) allele of ATG16L1 is associated with decreased risk for epithelial cell-derived thyroid carcinoma in a Dutch population
Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse.
GeneRIF
Hommes et al., Leiden, Netherlands. In Gastroenterology, 2012
gene affect autophagy and increase adaptive immunity in patients with Crohn's disease who carry ATG16L1 risk alleles
Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma.
GeneRIF
Virgin et al., Saint Louis, United States. In Cell Host Microbe, 2012
Atg5-Atg12/Atg16L1 protein complex is required for IFNgamma-mediated host defense against murine norovirus infection.
Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.
Review
GeneRIF
Thanigachalam et al., Orlando, United States. In World J Gastroenterol, 2012
role of ATG16L, NOD2 and IL23R in Crohn's disease [review]
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