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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

ATG1 Atg1p

Atg1, ULK1, Apg1
putative transmembrane protein G1p (AtG1) mRNA, complete (from NCBI)
Top mentioned proteins: mTOR, LC3, AMPK, V1a, CAN
Papers on Atg1
Atg101: not just an accessory subunit in the autophagy-initiation complex.
New
Mizushima et al., In Cell Struct Funct, Feb 2016
UNASSIGNED: The Saccharomyces cerevisiae autophagy-initiation complex, Atg1 kinase complex, consists of Atg1, Atg13, Atg17, Atg29, and Atg31, while the corresponding complex in most other eukaryotes, including mammals, is composed of ULK1 (or ULK2), Atg13, FIP200 (also known as RB1CC1), and Atg101.
Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.
New
Lei et al., China. In Oncotarget, Jan 2016
This activates the CaMKKβ-AMPK signaling pathway, which in turn inhibits mTOR and activates both ULK1 and Beclin 1, finally resulting in autophagy.
TBC1D14 regulates autophagy via the TRAPP complex and ATG9 traffic.
New
Tooze et al., Frankfurt am Main, Germany. In Embo J, Jan 2016
Importantly, TBC1D14 and TRAPPIII regulate ATG9 trafficking independently of ULK1.
Autophagy inhibitors.
Review
New
Pasquier, Vitry-sur-Seine, France. In Cell Mol Life Sci, Jan 2016
The cellular and molecular mechanisms underlying this process are highly complex and involve multiple proteins, including the kinases ULK1 and Vps34.
Association of ATG5 Gene Polymorphisms With Behçet's Disease and ATG10 Gene Polymorphisms With VKH Syndrome in a Chinese Han Population.
New
Yang et al., Chongqing, China. In Invest Ophthalmol Vis Sci, Jan 2016
Genotyping for genetic variants of 10 autophagy family genes (ATG5, ATG7, ATG10, ATG16L1, IRGM, LKKR2, ATG2A, DAP, ULK1, and TSC1) was performed using PCR-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP assays.
BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
New
Ishii et al., Suita, Japan. In Sci Rep, Dec 2015
The present data show AMPK-dependent cytoprotective roles of autophagy under conditions of therapeutic BRAF(V600E) inhibition, and AMPK was negatively correlated with BRAF(V600E)-dependent activation of MEK-ERK-RSK signaling and positively correlated with unc-51-like kinase 1 (ULK1), a key initiator of autophagy.
ATM functions at the peroxisome to induce pexophagy in response to ROS.
New
Impact
Walker et al., Houston, United States. In Nat Cell Biol, Oct 2015
In response to ROS, ATM signalling activates ULK1 and inhibits mTORC1 to induce autophagy.
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
New
Impact
Youle et al., Bethesda, United States. In Nature, Sep 2015
Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and WIPI1 to focal spots proximal to mitochondria, revealing a function for these autophagy receptors upstream of LC3.
Atg1 family kinases in autophagy initiation.
Review
New
Fujioka et al., Tokyo, Japan. In Cell Mol Life Sci, Aug 2015
Among all Atg proteins, Atg1 kinase in yeast and its counterpart in higher eukaryotes, ULK1 kinase, function as the most upstream factor in this process and mediate autophagy initiation.
Ambra1 at a glance.
Review
New
Cecconi et al., Roma, Italy. In J Cell Sci, Jul 2015
However, recent studies have revealed that Ambra1 can also coordinate a cell response upon starvation or other stresses that involve translocation of the autophagosome core complex to the endoplasmic reticulum (ER), regulative ubiquitylation and stabilization of the kinase ULK1, selective mitochondria removal and cell cycle downregulation.
Huntingtin functions as a scaffold for selective macroautophagy.
New
Impact
Zhang et al., Houston, United States. In Nat Cell Biol, Mar 2015
Maximal activation of selective autophagy during stress is attained by the ability of Huntingtin to bind ULK1, a kinase that initiates autophagy, which releases ULK1 from negative regulation by mTOR.
Autophagy in cellular metabolism and cancer.
Review
Thompson et al., In J Clin Invest, 2015
Emphasis is given to the interplay of autophagy with nutrient signaling through the ULK1 autophagy pre-initiation complex.
Autophagy in DNA damage response.
Review
Blasiak et al., Łódź, Poland. In Int J Mol Sci, 2014
mTORC1 represses autophagy via phosphorylation of the ULK1/2-Atg13-FIP200 complex thus preventing maturation of pre-autophagosomal structures.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Impact
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
Increased expression of TRPM3 in RCC leads to Ca(2+) influx, activation of CAMKK2, AMPK, and ULK1, and phagophore formation.
Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling.
Impact
Barber et al., Miami, United States. In Cell, 2013
We demonstrate here that, after autophagy-dependent STING delivery of TANK-binding kinase 1 (TBK1) to endosomal/lysosomal compartments and activation of transcription factors interferon regulatory factor 3 (IRF3) and NF-κB, STING is subsequently phosphorylated by serine/threonine UNC-51-like kinase (ULK1/ATG1), and IRF3 function is suppressed.
The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.
GeneRIF
Ohsumi et al., Yokohama, Japan. In J Biol Chem, 2012
mutations in the Atg1 AIM cause a significant defect in autophagy, without affecting the functions of Atg1 implicated in triggering autophagosome formation
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients.
GeneRIF
Zhu et al., Guangzhou, China. In Breast Cancer Res Treat, 2012
Decreased expression of ULK1 is associated with breast cancer progression, together with closely related to decreased autophagic capacity.
TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes.
GeneRIF
Tooze et al., London, United Kingdom. In J Cell Biol, 2012
The ULK1 and Atg9 are found on Rab11- and transferrin (Tfn) receptor (TfnR)-positive recycling endosomes.
Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions.
GeneRIF
Auberger et al., Nice, France. In Blood, 2012
Unexpected and essential role of autophagy during monocyte differentiation and acquisition of macrophage functions.
GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy.
Impact
GeneRIF
Lin et al., Xiamen, China. In Science, 2012
glycogen synthase kinase-3 (GSK3), when deinhibited by default in cells deprived of growth factors, activates acetyltransferase TIP60 through phosphorylating TIP60-Ser86, which acetylates and stimulates the protein kinase ULK1, which is required for autophagy
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