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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Activating transcription factor 6 beta

ATF6beta, CREB-RP, Creb-related protein
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Papers on ATF6beta
Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.
GeneRIF
Takeda et al., Suita, Japan. In Virulence, 2012
Toxoplasma virulence factor ROP18 inactivates host innate and adaptive immune responses by targeting ATF6beta.
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.
GeneRIF
Takeda et al., Suita, Japan. In J Exp Med, 2011
interference with ATF6beta-dependent immune responses is a novel pathogenic mechanism induced by ROP18
N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.
GeneRIF
Shen et al., Shanghai, China. In J Cell Biochem, 2009
unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha
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