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Activating transcription factor 6 beta

ATF6beta, CREB-RP, Creb-related protein
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ATF6, CREB, IRE1, CAN, CIs
Papers on ATF6beta
Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.
GeneRIF
Takeda et al., Suita, Japan. In Virulence, 2012
Toxoplasma virulence factor ROP18 inactivates host innate and adaptive immune responses by targeting ATF6beta.
ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP18.
GeneRIF
Takeda et al., Suita, Japan. In J Exp Med, 2011
interference with ATF6beta-dependent immune responses is a novel pathogenic mechanism induced by ROP18
N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha.
GeneRIF
Shen et al., Shanghai, China. In J Cell Biochem, 2009
unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha
Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway.
Kilberg et al., Gainesville, United States. In Biochem J, 2009
In addition, siRNA (small interfering RNA)-mediated knockdown of XBP1 (X-box-binding protein 1), ATF6alpha or ATF6beta expression did not affect ASNS transcription, whereas siRNA against ATF4 suppressed ASNS transcription during UPR activation.
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum.
Mori et al., Kyoto, Japan. In Cell Struct Funct, 2007
ATF6 is an ER-membrane-bound transcription factor activated by ER stress-induced proteolysis which consists of two closely related factors, ATF6alpha and ATF6beta, in mammals.
Structural and functional comparison of the non-structural protein 4B in flaviviridae.
Zeuzem et al., Homburg, Germany. In J Mol Graph Model, 2007
In addition, we model the interaction of the bZIP region with the recently identified interaction partner CREB-RP/ATF6beta, a human activating transcription factor involved in ER-stress.
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
Mori et al., Kyoto, Japan. In Dev Cell, 2007
Here, we generated ATF6alpha- and ATF6beta-knockout mice, which developed normally, and then found that their double knockout caused embryonic lethality.
Coronavirus 3CLpro proteinase cleavage sites: possible relevance to SARS virus pathology.
Blom et al., Denmark. In Bmc Bioinformatics, 2004
Cleavage sites were predicted in proteins such as the cystic fibrosis transmembrane conductance regulator (CFTR), transcription factors CREB-RP and OCT-1, and components of the ubiquitin pathway.
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
Glembotski et al., San Diego, United States. In J Biol Chem, 2004
The endoplasmic reticulum (ER) transmembrane proteins, ATF6alpha and ATF6beta, are cleaved in response to ER stress, which can be induced by tunicamycin.
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response.
Glimcher et al., Boston, United States. In Mol Cell Biol, 2003
We have investigated here the contribution of the UPR transcription factors XBP-1, ATF6alpha, and ATF6beta to UPR target gene expression.
A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.
Mori et al., Kyoto, Japan. In J Biol Chem, 2003
The other type comprises the activating transcription factors 6 (ATF6alpha and ATF6beta), which are activated in response to ER stress.
Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta.
Hotta et al., Kōbe, Japan. In Biochem Biophys Res Commun, 2003
By using a yeast two-hybrid assay, cyclic AMP-response-element-binding protein-related protein (CREB-RP), also called activating transcription factor 6beta (ATF6beta), was identified as a cellular protein that interacts with the NS4B protein of hepatitis C virus.
Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus.
Hotta et al., Kōbe, Japan. In Virus Res, 2002
NS4A and NS4B inhibited p21/Waf1 most strongly, followed by RNase L, p53, a C-terminally truncated form of CREB-RP and 2'-5' oligoadenylate synthetase.
Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.
Mori et al., Kyoto, Japan. In Biochem J, 2001
This protein encoded by the G13 (cAMP response element binding protein-related protein) gene is constitutively synthesized as a type II transmembrane glycoprotein anchored in the ER membrane and processed into a soluble form upon ER stress as occurs with ATF6.
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
Mori et al., Kyoto, Japan. In Mol Cell Biol, 2001
We recently proposed that ER stress response factor (ERSF) binding to ERSE is a heterologous protein complex consisting of the constitutive component NF-Y (CBF) binding to CCAAT and an inducible component binding to CCACG and identified the basic leucine zipper-type transcription factors ATF6alpha and ATF6beta as inducible components of ERSF.
Identification of a telomeric boundary of the HLA region with potential for predisposition to human narcolepsy.
Tokunaga et al., Tokyo, Japan. In Immunogenetics, 2000
From the gene map of the HLA region, the cyclic AMP response element-binding protein-related protein gene (CREB-RP) appeared to be located at the telomeric end in the 50-kb region.
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