Lactate dehydrogenase 5 expression in melanoma increases with disease progression and is associated with expression of Bcl-XL and Mcl-1, but not Bcl-2 proteins
In Oncogene, 2009
... against Mcl-1 and the rabbit polyclonal antibodies (Abs) against Ets-1, Ets-2, c-Rel, XBP-1, GRP78, IRE1a, ATF6 and PERK were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ... Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... (1:500, NB100-2323, Novus Biologicals), anti-ATF6 (full-length and cleaved forms; 1:200, IMG-273, IMGENEX, San Diego, CA, USA), ...
Cell death induced by endoplasmic reticulum stress.
l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
Endoplasmic Reticulum Stress and Ethanol Neurotoxicity.
Lexington, United States. In Biomolecules, 2014
The accumulation of unfolded or misfolded proteins in the ER lumen triggers ER stress and induces unfolded protein response (UPR) which are mediated by three transmembrane ER signaling proteins: pancreatic endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6).