Overview of macroautophagy regulation in mammalian cells
In International Journal of Biological Sciences, 2009
... Anti-LC3, anti-Beclin1, anti-α-synuclein, anti-p70S6kinase, anti-p-p70S6Kinase, anti-caspase-3, anti-mTOR, anti-p-mTOR, anti-tau5, anti-tau396, anti-tau404, anti-Grp78, anti-Bcl2, and anti-ATF4 bodies were purchased from Cell Signaling (Beverly, MA, USA) ...
Cell death induced by endoplasmic reticulum stress.
l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
Seoul, South Korea. In Free Radic Biol Med, Nov 2015
Several transcriptional factors, including p53, HIF-1, FoxO, C/EBP-β, ATF4, Nrf2, and PGC-1α, contribute directly to the transcriptional activation of Sestrin genes in response to various types of stress.
Role of Irisin on the bone-muscle functional unit.
Bari, Italy. In Bonekey Rep, 2014
Irisin exerts its effect prevalently on osteoblast lineage by enhancing differentiation and activity of bone-forming cells, through the increase in activating transcription factor 4 expression.
Paneth cells as a site of origin for intestinal inflammation.
Cambridge, United Kingdom. In Nature, 2013
Xbp1(ΔIEC) mice show autophagosome formation in hypomorphic Paneth cells, which is linked to ER stress via protein kinase RNA-like endoplasmic reticulum kinase (PERK), elongation initiation factor 2α (eIF2α) and activating transcription factor 4 (ATF4).