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Activating transcription factor 4

ATF4, Activating Transcription Factor 4, CREB2
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CHOP, GRP78, V1a, ACID, CAN
Papers using ATF4 antibodies
Overview of macroautophagy regulation in mammalian cells
Chen Jingyuan et al., In International Journal of Biological Sciences, 2009
... Anti-LC3, anti-Beclin1, anti-α-synuclein, anti-p70S6kinase, anti-p-p70S6Kinase, anti-caspase-3, anti-mTOR, anti-p-mTOR, anti-tau5, anti-tau396, anti-tau404, anti-Grp78, anti-Bcl2, and anti-ATF4 bodies were purchased from Cell Signaling (Beverly, MA, USA) ...
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
Ron David et al., In The Journal of Cell Biology, 2001
... The 5′ end of mouse ATF4 cDNA was recovered by 5′RACE from mRNA of tunicamycin-treated mouse fibroblasts and was ligated between the HindIII-BamHI sites of pEGFP-N1 (CLONTECH Laboratories, Inc.), fusing the ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... (1:200, sc-101670, Santa Cruz Biotechnology), anti-ATF4 (1:200, sc-200, Santa Cruz Biotechnology), anti-IRE1 ...
Papers on ATF4
c-Jun N-terminal Kinase-Dependent Endoplasmic Reticulum Stress Pathway is Critically Involved in Arjunic Acid Induced Apoptosis in Non-Small Cell Lung Cancer Cells.
Kim et al., Suwŏn, South Korea. In Phytother Res, Feb 2016
Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 α, ATF4, p-eIF2α, and C/EBP homologous protein (CHOP) in A549 and H460 cells.
Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.
Cao et al., Suzhou, China. In Biochem Pharmacol, Feb 2016
Mechanistic studies revealed that DHE selectively activated the intracellular tumor suppressive stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (3DDIT3), through upregulation of activating transcription factor 4 (ATF4).
Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation.
Johnson et al., Canada. In Cell Metab, Feb 2016
Transcriptome, proteome, and network analysis revealed alleviation of chronic endoplasmic reticulum (ER) stress, indicated by reduced Ddit3, Trib3, and Atf4 expression; reduced Xbp1 splicing; and reduced phospho-eIF2α.
KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism.
Ding et al., Chongqing, China. In Cell Rep, Feb 2016
This action of KDM4C requires ATF4, a transcriptional master regulator of amino acid metabolism and stress responses.
Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.
Evstafieva et al., Moscow, Russia. In Cell Cycle, Feb 2016
In response to the respiratory chain inhibitors we observed an induction of ATF4, the key transcription factor of the integrated stress response (ISR).
NRF2 regulates serine biosynthesis in non-small cell lung cancer.
Cantley et al., New York City, United States. In Nat Genet, Dec 2015
We found that NRF2 controls the expression of the key serine/glycine biosynthesis enzyme genes PHGDH, PSAT1 and SHMT2 via ATF4 to support glutathione and nucleotide production.
Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2.
Terzi et al., Paris, France. In Nat Commun, Dec 2015
Mechanistically, we show that albumin induces tubular unfolded protein response via cytosolic calcium rise, which leads to tubular apoptosis by Lipocalin 2 (LCN2) modulation through ATF4.
Cell death induced by endoplasmic reticulum stress.
Muñoz-Pinedo et al., l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
Central to the unfolded protein response are the sensors PERK, IRE1 and ATF6, as well as other signaling nodes such as c-Jun N-terminal kinase 1 (JNK) and the downstream transcription factors XBP1, ATF4 and CHOP.
The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1.
Bae et al., Seoul, South Korea. In Free Radic Biol Med, Nov 2015
Several transcriptional factors, including p53, HIF-1, FoxO, C/EBP-β, ATF4, Nrf2, and PGC-1α, contribute directly to the transcriptional activation of Sestrin genes in response to various types of stress.
Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer's Disease.
Majsterek et al., Łódź, Poland. In Curr Med Chem, 2014
That attenuates general translation and, on the other hand, promotes the preferential synthesis of Activating Transcription Factor 4 (ATF4) and secretase β (BACE1) - a pivotal enzyme responsible for the initiation of the amyloidogenic pathway resulting in the generation of the amyloid β (Aβ) variant with high ability to form toxic senile plaques in AD brains.
Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage.
Komoike et al., Tokyo, Japan. In Int J Mol Sci, 2014
In addition, the expression of activating transcription factor 4 (ATF4), a transcription factor that induces the expression of UPR target genes, is up-regulated through alternative translation.
Role of Irisin on the bone-muscle functional unit.
Grano et al., Bari, Italy. In Bonekey Rep, 2014
Irisin exerts its effect prevalently on osteoblast lineage by enhancing differentiation and activity of bone-forming cells, through the increase in activating transcription factor 4 expression.
Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.
Hengst et al., New York City, United States. In Cell, 2014
We found that locally applied Aβ1-42 initiates axonal synthesis of a defined set of proteins including the transcription factor ATF4. Inhibition of local translation and retrograde transport or knockdown of axonal Atf4 mRNA abolished Aβ-induced ATF4 transcriptional activity and cell loss.
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
Tabas et al., New York City, United States. In Cell Metab, 2014
The mechanism of improvement begins with induction of ATF6 and the ATF6 target p58(IPK), a chaperone that suppresses the PERK-p-eIF2α-ATF4 branch of the UPR.
Paneth cells as a site of origin for intestinal inflammation.
Blumberg et al., Cambridge, United Kingdom. In Nature, 2013
Xbp1(ΔIEC) mice show autophagosome formation in hypomorphic Paneth cells, which is linked to ER stress via protein kinase RNA-like endoplasmic reticulum kinase (PERK), elongation initiation factor 2α (eIF2α) and activating transcription factor 4 (ATF4).
Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain.
Ohdo et al., Fukuoka, Japan. In Mol Pharmacol, 2012
The circuit of circadian-basis molecular regulation between the clockwork system and mouse 5-HTT gene is connected by the ATF4 signaling pathway.
Activating transcription factor 4 regulates stearate-induced vascular calcification.
Miyazaki et al., Aurora, United States. In J Lipid Res, 2012
activation of ATF4 mediates vascular calcification induced by stearate
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.
Wek et al., Indianapolis, United States. In J Biol Chem, 2012
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein beta (C/EBPbeta) differentially regulates integrated stress response
Heme-regulated eIF2α kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
Chen et al., Cambridge, United States. In Blood, 2012
Heme-regulated eIF2alpha kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis.
Platelet-derived growth factor-BB mediates cell migration through induction of activating transcription factor 4 and tenascin-C.
Khachigian et al., Sydney, Australia. In Am J Pathol, 2012
The findings demonstrate the role of ATF-4 in both injury- and PDGF-BB-inducible tenascin-4 expression and cell migration.
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