Conventional therapies fail to target inflammation and immune imbalance in subjects with stable coronary artery disease: A system-based approach.
Chandīgarh, India. In Atherosclerosis, 18 Nov 2014
Microarray analysis revealed that despite treatment 513 genes were differentially expressed that play important role in various biological processes such as, i.e. inflammation (CXCR4, CXCL2, PTGS2), immune imbalance (IL-8, IL-Iß, CCL3), and active atherosclerosis (DUSP-1, OSM, ATF3).
Regulatory SNPs and transcription factor binding sites in ADRBK1, AKT3, ATF3, DIO2, TBXA2R and VEGFA.
Seattle, United States. In Transcription, Oct 2014
UNLABELLED: Abstract Regulatory single nucleotide polymorphisms (rSNPs) which change the transcriptional factor binding sites (TFBS) for transcriptional factors (TFs) to bind DNA were reviewed for the ADRBK1 (GRK2), AKT3, ATF3, DIO2, TBXA2R and VEGFA genes.
High-density lipoproteins put out the fire.
New York City, United States. In Cell Metab, Mar 2014
(2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.
Molecular and Cellular Characterization of a Zebrafish Optic Pathway Tumor Line Implicates Glia-Derived Progenitors in Tumorigenesis.
Ames, United States. In Plos One, Dec 2013
We performed transcriptome analysis of pre-tumorous retina and retinal tumor tissue and found changes in gene expression signatures of radial glia and astrocytes (slc1a3), activated glia (atf3, blbp, apoeb), proliferating neural progenitors (foxd3, nestin, cdh2, her9/hes1), and glioma markers (S100β, vim).
Aetiology of hypospadias: a systematic review of genes and environment.
Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells.
Yangsan, South Korea. In Biochem Biophys Res Commun, 2012
these results demonstrate that ATF3 represses the C/EBPalpha gene, resulting in inhibition of adipocyte differentiation, and thus plays a role in hypoxia-mediated inhibition of adipocyte differentiation.
Screening for adiponectin secretion regulators.
Ōsaka, Japan. In Vitam Horm, 2011
On the other hand, transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT-enhancer-binding protein α, and forkhead box O1 (FoxO1) upregulate adiponectin expression, although the activating transcription factor 3 and cAMP response element-binding protein downregulate it.
Multiple transcription factor families regulate axon growth and regeneration.
Miami, United States. In Dev Neurobiol, 2011
Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor κ-light chain enhancer of activated B cells (NFκB), and Krüppel-like factors (KLFs).