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Activating transcription factor 3

ATF3, Activating Transcription Factor 3
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: GDNF, AP-1, CAN, V1a, HAD
Papers using ATF3 antibodies
Selective targeting of radiation-resistant tumor-initiating cells.
Supplier
Oshima Robert, In PLoS ONE, 2009
... The derivation of the BK5.ATF3 transgenic mice has been described ...
GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
Supplier
Ochsmann Thomas et al., In Frontiers in Neurology, 2002
... buffer for 10 min and incubated overnight in a humid chamber at 4°C with either rabbit polyclonal anti-ATF3 sc-188, 1:100 (Santa Cruz Biotechnology, Inc ...
Papers on ATF3
The expression of miR-30a* and miR-30e* is associated with a dualistic model for grading ovarian papillary serious carcinoma.
New
Zhao et al., Dalian, China. In Int J Oncol, 27 Apr 2014
ATF3 and MYC were indicated as potential co-targets of miR-30a* and miR-30e*, and showed a significant upregulation in type II patients.
The gene profile in the spleen under massive partial hepatectomy using cDNA microarray and pathway analysis.
New
Takasu et al., Tokushima, Japan. In J Gastroenterol Hepatol, 14 Apr 2014
Also, immediate early response genes including early growth response-1 (EGR1), FBJ murine osteosarcoma (FOS) and activating transcription factor 3 (ATF3) related pathway were up-regulated in the spleen.
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
Review
New
Khan et al., United States. In Life Sci, 11 Mar 2014
Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
High-density lipoproteins put out the fire.
New
Impact
Fisher et al., New York City, United States. In Cell Metab, 04 Mar 2014
(2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.
New
Impact
Latz et al., Bonn, Germany. In Nat Immunol, 28 Feb 2014
Here we identify the transcriptional regulator ATF3, as an HDL-inducible target gene in macrophages that downregulates the expression of Toll-like receptor (TLR)-induced proinflammatory cytokines.
Voltage-gated sodium channel expression in mouse DRG after SNI leads to re-evaluation of projections of injured fibers.
New
Decosterd et al., Lausanne, Switzerland. In Mol Pain, Dec 2013
Consequently, the proportion of axotomized neurons in the L3, L4 and L5 DRG after SNI was characterized by studying the expression of activating transcription factor 3 (ATF3).
Gene Therapy for Neuropathic Pain by Silencing of TNF-α Expression with Lentiviral Vectors Targeting the Dorsal Root Ganglion in Mice.
New
Maegawa et al., Ōtsu, Japan. In Plos One, Dec 2013
These animals were found to display up-regulated mRNA expression of activating transcription factor 3 (ATF3) and neuropeptide Y (NPY), injury markers, and interleukin (IL)-6, an inflammatory cytokine in the ipsilateral L5 DRG.
A review of adaptive mechanisms in cell responses towards oxidative stress caused by dental resin monomers.
Review
New
Schweikl et al., Regensburg, Germany. In Biomaterials, Jun 2013
We will also consider the influence of monomer-induced oxidative stress on central signal transduction pathways including mitogen-activated protein kinases (MAPK) ERK1/2, p38, and JNK as well as the stress-activated transcription factors downstream Elk-1, ATF-2, ATF-3, and cJun.
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.
New
Impact
van Lohuizen et al., Amsterdam, Netherlands. In Cancer Cell, Jun 2013
We discovered that Bmi1 is important in the cellular response to the transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) and endoplasmic reticulum (ER) stress pathways, in part converging on the Atf3 transcriptional repressor.
Marine- and plant-derived ω-3 fatty acids differentially regulate prostate cancer cell proliferation.
New
Thompson et al., Houston, United States. In Mol Clin Oncol, May 2013
In addition, DHA and EPA increased the gene expression of the pro-apoptotic protein activating transcription factor 3 mRNA.
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Impact
Akira et al., Ōsaka, Japan. In Immunity, 2013
We also found that ATF3 was an inhibitor of neutrophil differentiation and that Jdp2 directly suppresses its expression via inhibition of histone acetylation.
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor.
GeneRIF
Yan et al., Albany, United States. In Mol Cell Biol, 2012
ATF3 is a novel repressor of androgen signaling that can inhibit AR functions, allowing prostate cells to restore homeostasis
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Impact
Glass et al., Berlin, Germany. In Nat Med, 2012
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
Enhancement of cisplatin cytotoxicity by disulfiram involves activating transcription factor 3.
GeneRIF
Dimitroulakos et al., Ottawa, Canada. In Anticancer Res, 2012
ATF3 protein expression was up-regulated after cytotoxic doses of cisplatin treatment and it directly bound to the CHOP gene promoter, increasing this pro-apoptotic protein's expression.
Aetiology of hypospadias: a systematic review of genes and environment.
Review
Roeleveld et al., Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells.
GeneRIF
Jung et al., Yangsan, South Korea. In Biochem Biophys Res Commun, 2012
these results demonstrate that ATF3 represses the C/EBPalpha gene, resulting in inhibition of adipocyte differentiation, and thus plays a role in hypoxia-mediated inhibition of adipocyte differentiation.
The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network.
GeneRIF
Freeman et al., Los Angeles, United States. In Plos One, 2011
the role of cholesterol in prostate health, and provide a novel role for ATF3, and associated proteins within a large signaling network, as a cholesterol-sensing mechanism.
Screening for adiponectin secretion regulators.
Review
Nagata et al., Ōsaka, Japan. In Vitam Horm, 2011
On the other hand, transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT-enhancer-binding protein α, and forkhead box O1 (FoxO1) upregulate adiponectin expression, although the activating transcription factor 3 and cAMP response element-binding protein downregulate it.
Multiple transcription factor families regulate axon growth and regeneration.
Review
Goldberg et al., Miami, United States. In Dev Neurobiol, 2011
Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor κ-light chain enhancer of activated B cells (NFκB), and Krüppel-like factors (KLFs).
Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin.
GeneRIF
Bruskin et al., Moscow, Russia. In Bull Exp Biol Med, 2011
Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.
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