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Activating transcription factor 3
ATF3, Activating Transcription Factor 3
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011] (from
NCBI)
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Papers using
ATF3
antibodies
Selective targeting of radiation-resistant tumor-initiating cells.
Supplier
In PLoS ONE, 2009
... The derivation of the BK5.ATF3 transgenic mice has been described ...
GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
Supplier
In Frontiers in Neurology, 2002
... buffer for 10 min and incubated overnight in a humid chamber at 4°C with either rabbit polyclonal anti-ATF3 sc-188, 1:100 (Santa Cruz Biotechnology, Inc ...
Papers on
ATF3
Expression of activating transcription factor 3 (ATF3) in uninjured dorsal root ganglion neurons in a lower trunk avulsion pain model in rats.
New
Chiba, Japan. In Eur Spine J, 08 Apr 2013
Activation of DRG neurons was immunohistochemically examined using anti-ATF3 (a marker for neuron activation) antibodies 21 days after surgery.
Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice.
New
Maebashi, Japan. In Diabetologia, 06 Apr 2013
Activating transcription factor 3 (ATF3) is an adaptive response transcription factor.
Differential regulation of TNF receptor 1 and receptor 2 in adiponectin expression following myocardial ischemia.
New
Taiyuan, China. In Int J Cardiol, 02 Apr 2013
Mechanistically, TNFR1 knockout significantly inhibited, whereas TNFR2 knockout further enhanced TNFα-induced mRNA and protein expression of ATF3, a transcriptional factor known to significantly inhibit adiponectin expression.
Anticancer activity of olive oil hydroxytyrosyl acetate in human adenocarcinoma Caco-2 cells.
New
In J Agric Food Chem, 01 Apr 2013
Gene expression of proteins involved in cell cycle (p21, p53, cyclin B1 and cyclin G2) and programmed cell death (BNIP3, BNIP3L, PDCD4 and ATF3), as well as phase I and phase II detoxifying enzymes CYPA1 and UGT1A10, were evaluated by RT-PCR after 24 h of exposure of Caco-2/TC7 cells to 5, 10 and 50 M of HTy-Ac.
Regulation of chemokines, CCL3 and CCL4, by Interferon-gamma and Nitric oxide synthase 2 in mouse macrophages and during Salmonella enterica Serovar Typhimurium infection.
New
Bengaluru, India. In J Infect Dis, 21 Mar 2013
IFNγ repressed CCL3 and CCL4 in a STAT1-NOS2-p38MAPK-ATF3 dependent pathway in A-PECs.
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
New
Impact
Ōsaka, Japan. In Immunity, Jan 2013
We also found that ATF3 was an inhibitor of neutrophil differentiation and that Jdp2 directly suppresses its expression via inhibition of histone acetylation.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
New
Impact
Berlin, Germany. In Nat Med, Aug 2012
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression.
Impact
Tübingen, Germany. In Nat Med, 2012
Here we show in humans that the loss of the major reactive oxygen species (ROS) scavenger, glutathione (GSH), during SAIS directly correlates with an increase in the expression of activating transcription factor 3 (ATF3).
Transcriptional activity of ATF3 in the stromal compartment of tumors promotes cancer progression.
GeneRIF
Israel. In Carcinogenesis, 2011
found that the ability of stromal ATF3 to promote cancer progression is mediated by transcriptional repression of CLDN1 and induction of CXCL12 and RGS4
Multiple transcription factor families regulate axon growth and regeneration.
Review
Miami, United States. In Dev Neurobiol, 2011
Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor κ-light chain enhancer of activated B cells (NFκB), and Krüppel-like factors (KLFs).
Screening for adiponectin secretion regulators.
Review
Ōsaka, Japan. In Vitam Horm, 2011
On the other hand, transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT-enhancer-binding protein α, and forkhead box O1 (FoxO1) upregulate adiponectin expression, although the activating transcription factor 3 and cAMP response element-binding protein downregulate it.
Role of activating transcription factor 3 in low glucose- and thapsigargin-induced apoptosis in cultured mouse islets.
GeneRIF
Brussels, Belgium. In Biochem Biophys Res Commun, 2011
the increase in Atf3 gene expression induced by thapsigargin and low glucose concentrations slightly contributes to the stimulation of islet cell apoptosis under these culture conditions.
ATF3 inhibits PDX-1-stimulated transactivation.
GeneRIF
Seoul, South Korea. In Biochem Biophys Res Commun, 2011
these results suggest that ATF3 inhibits PDX-1-mediated transactivation through the inhibition of p300-stimulated coactivation, which may lead to beta-cell dysfunction by ER stress.
Respiratory motoneurons and pathological conditions: lessons from hypoglossal motoneurons challenged by excitotoxic or oxidative stress.
Review
Trieste, Italy. In Respir Physiol Neurobiol, 2011
Although these two insults induce separate functional signatures, the consequences on HMs after a few hours are similar and are preceded by activation of the stress transcription factor ATF-3.
ATF3 represses PDX-1 expression in pancreatic β-cells.
GeneRIF
Yangsan, South Korea. In Biochem Biophys Res Commun, 2011
these results demonstrate that ATF3 represses PDX-1 expression via binding to an ATF3-responsive element in its promoter, which plays an important role in suppression of pancreatic beta-cells function.
Expression of Id-1 is regulated by MCAM/MUC18: a missing link in melanoma progression.
GeneRIF
Houston, United States. In Cancer Res, 2011
MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis
Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis.
Review
Lausanne, Switzerland. In Cancer Res, 2011
The underlying mechanism involves interruption of a double negative regulatory axis, whereby calcineurin and nuclear factors of activated T-cell signaling inhibits expression of ATF3, a negative regulator of p53.
Biochemical specificity of von Economo neurons in hominoids.
Review
Washington, D.C., United States. In Am J Hum Biol, 2011
METHODS: In this study, we used quantitative stereologic methods to examine the expression of three such proteins that are localized in VENs-activating-transcription factor 3 (ATF3), interleukin 4 receptor (IL4Rα), and neuromedin B (NMB).
Opposing roles for calcineurin and ATF3 in squamous skin cancer.
Impact
GeneRIF
United States. In Nature, 2010
increased ATF3 expression accounts for suppression of p53-dependent senescence and enhanced tumorigenic potential
Function of C/EBPdelta in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals.
Impact
Seattle, United States. In Nat Immunol, 2009
Here we use systems-biology approaches to predict and confirm the existence of a gene-regulatory network involving dynamic interaction among the transcription factors NF-kappaB, C/EBPdelta and ATF3 that controls inflammatory responses.
