Defective autophagy impairs ATF3 activity and worsens lung injury during endotoxemia.
Oviedo, Spain. In J Mol Med (berl), 19 Mar 2014
We found an increased inflammatory response (increased neutrophilic infiltration, higher levels of Il6, Il12p40, and Cxcl2) in the lungs from knockout mice and identified perinuclear sequestration of the anti-inflammatory transcription factor ATF3 as the putative mechanism responsible for the differences between genotypes.
High-density lipoproteins put out the fire.
New York City, United States. In Cell Metab, 04 Mar 2014
(2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.
Aetiology of hypospadias: a systematic review of genes and environment.
Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
Screening for adiponectin secretion regulators.
Ōsaka, Japan. In Vitam Horm, 2011
On the other hand, transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT-enhancer-binding protein α, and forkhead box O1 (FoxO1) upregulate adiponectin expression, although the activating transcription factor 3 and cAMP response element-binding protein downregulate it.
Multiple transcription factor families regulate axon growth and regeneration.
Miami, United States. In Dev Neurobiol, 2011
Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor κ-light chain enhancer of activated B cells (NFκB), and Krüppel-like factors (KLFs).
ATF3 inhibits PDX-1-stimulated transactivation.
Seoul, South Korea. In Biochem Biophys Res Commun, 2011
these results suggest that ATF3 inhibits PDX-1-mediated transactivation through the inhibition of p300-stimulated coactivation, which may lead to beta-cell dysfunction by ER stress.
ATF3 represses PDX-1 expression in pancreatic β-cells.
Yangsan, South Korea. In Biochem Biophys Res Commun, 2011
these results demonstrate that ATF3 represses PDX-1 expression via binding to an ATF3-responsive element in its promoter, which plays an important role in suppression of pancreatic beta-cells function.