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Activating transcription factor 3

ATF3, Activating Transcription Factor 3
This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011] (from NCBI)
Top mentioned proteins: GDNF, AP-1, CAN, V1a, HAD
Papers using ATF3 antibodies
Selective targeting of radiation-resistant tumor-initiating cells.
Supplier
Oshima Robert, In PLoS ONE, 2009
... The derivation of the BK5.ATF3 transgenic mice has been described ...
GDNF and BDNF alter the expression of neuronal NOS, c-Jun, and p75 and prevent motoneuron death following spinal root avulsion in adult rats
Supplier
Ochsmann Thomas et al., In Frontiers in Neurology, 2002
... buffer for 10 min and incubated overnight in a humid chamber at 4°C with either rabbit polyclonal anti-ATF3 sc-188, 1:100 (Santa Cruz Biotechnology, Inc ...
Papers on ATF3
ATF3 Protects Pulmonary Resident Cells from Acute Lung Injury by Preventing Keap-1-mediated Nrf2 Degradation in a DJ-1-dependent manner.
New
Dos Santos et al., Toronto, Canada. In Antioxid Redox Signal, 17 Dec 2014
Absence of activating transcription factor 3 (ATF3) confers susceptibility to ALI/VILI.
Runx2, a target gene for activating transcription factor-3 in human breast cancer cells.
New
Selvamurugan et al., India. In Tumour Biol, 08 Dec 2014
UNLABELLED: Activating transcription factor (ATF-3) is a stress response gene and is induced by transforming growth factor beta 1 (TGF-β1) in breast cancer cells.
Activating transcription factor 3 interferes with p21 activation in histone deacetylase inhibitor-induced growth inhibition of epidermoid carcinoma cells.
New
Yang et al., Beijing, China. In Tumour Biol, 05 Dec 2014
Recently, we reported that activating transcription factor 3 (ATF3) could significantly promote skin cancer cell growth.
CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats.
New
Bourgoin et al., Paris, France. In Eur J Pain, 05 Dec 2014
CCI-ION was associated with marked up-regulation of neuronal and glial inflammatory markers (ATF3, IL6, iNOS, COX2) in ipsilateral trigeminal ganglion but not spinal trigeminal nucleus.
Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.
New
Impact
Lamb et al., Houston, United States. In Nat Med, Jul 2014
Elevated levels of VAMP7 markedly intensified ESR1-potentiated transcriptional activity by increasing ESR1 protein cellular content upon ligand stimulation and upregulated the expression of estrogen-responsive genes including ATF3, CYR61 and CTGF, all of which have been implicated in human hypospadias.
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
Review
New
Khan et al., United States. In Life Sci, May 2014
Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
High-density lipoproteins put out the fire.
New
Impact
Fisher et al., New York City, United States. In Cell Metab, Mar 2014
(2013), now report that high-density lipoproteins (HDL) can reprogram macrophages to be less inflammatory through an ATF3-dependent pathway, providing another mechanistic basis for the atheroprotective properties of HDL.
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.
New
Impact
Latz et al., Bonn, Germany. In Nat Immunol, Feb 2014
Here we identify the transcriptional regulator ATF3, as an HDL-inducible target gene in macrophages that downregulates the expression of Toll-like receptor (TLR)-induced proinflammatory cytokines.
Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis.
New
Sasano et al., In Tohoku J Exp Med, Dec 2013
The activating transcription factor 3 (ATF3) is a member of the cAMP-responsive element-binding (CREB) protein family of transcription factors.
A review of adaptive mechanisms in cell responses towards oxidative stress caused by dental resin monomers.
Review
New
Schweikl et al., Regensburg, Germany. In Biomaterials, Jun 2013
We will also consider the influence of monomer-induced oxidative stress on central signal transduction pathways including mitogen-activated protein kinases (MAPK) ERK1/2, p38, and JNK as well as the stress-activated transcription factors downstream Elk-1, ATF-2, ATF-3, and cJun.
In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.
New
Impact
van Lohuizen et al., Amsterdam, Netherlands. In Cancer Cell, Jun 2013
We discovered that Bmi1 is important in the cellular response to the transforming growth factor-β/bone morphogenetic protein (TGF-β/BMP) and endoplasmic reticulum (ER) stress pathways, in part converging on the Atf3 transcriptional repressor.
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Impact
Akira et al., Ōsaka, Japan. In Immunity, 2013
We also found that ATF3 was an inhibitor of neutrophil differentiation and that Jdp2 directly suppresses its expression via inhibition of histone acetylation.
The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor.
GeneRIF
Yan et al., Albany, United States. In Mol Cell Biol, 2012
ATF3 is a novel repressor of androgen signaling that can inhibit AR functions, allowing prostate cells to restore homeostasis
Enhancement of cisplatin cytotoxicity by disulfiram involves activating transcription factor 3.
GeneRIF
Dimitroulakos et al., Ottawa, Canada. In Anticancer Res, 2012
ATF3 protein expression was up-regulated after cytotoxic doses of cisplatin treatment and it directly bound to the CHOP gene promoter, increasing this pro-apoptotic protein's expression.
Aetiology of hypospadias: a systematic review of genes and environment.
Review
Roeleveld et al., Nijmegen, Netherlands. In Hum Reprod Update, 2012
Studies screening groups of patients with hypospadias for single gene defects found mutations in WT1, SF1, BMP4, BMP7, HOXA4, HOXB6, FGF8, FGFR2, AR, HSD3B2, SRD5A2, ATF3, MAMLD1, MID1 and BNC2.
ATF3 inhibits adipocyte differentiation of 3T3-L1 cells.
GeneRIF
Jung et al., Yangsan, South Korea. In Biochem Biophys Res Commun, 2012
these results demonstrate that ATF3 represses the C/EBPalpha gene, resulting in inhibition of adipocyte differentiation, and thus plays a role in hypoxia-mediated inhibition of adipocyte differentiation.
The response of the prostate to circulating cholesterol: activating transcription factor 3 (ATF3) as a prominent node in a cholesterol-sensing network.
GeneRIF
Freeman et al., Los Angeles, United States. In Plos One, 2011
the role of cholesterol in prostate health, and provide a novel role for ATF3, and associated proteins within a large signaling network, as a cholesterol-sensing mechanism.
Screening for adiponectin secretion regulators.
Review
Nagata et al., Ōsaka, Japan. In Vitam Horm, 2011
On the other hand, transcription factors such as peroxisome proliferator-activated receptor-γ (PPARγ), CCAAT-enhancer-binding protein α, and forkhead box O1 (FoxO1) upregulate adiponectin expression, although the activating transcription factor 3 and cAMP response element-binding protein downregulate it.
Multiple transcription factor families regulate axon growth and regeneration.
Review
Goldberg et al., Miami, United States. In Dev Neurobiol, 2011
Here we will discuss transcription factors that regulate neurite growth in vitro and in vivo, including p53, SnoN, E47, cAMP-responsive element binding protein (CREB), signal transducer and activator of transcription 3 (STAT3), nuclear factor of activated T cell (NFAT), c-Jun activating transcription factor 3 (ATF3), sex determining region Ybox containing gene 11 (Sox11), nuclear factor κ-light chain enhancer of activated B cells (NFκB), and Krüppel-like factors (KLFs).
Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin.
GeneRIF
Bruskin et al., Moscow, Russia. In Bull Exp Biol Med, 2011
Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.
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