Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols.
Cambridge, United States. In Metab Eng, Jan 2016
First, the plasmid pZ8_TAG4 was constructed which allows the heterologous expression of four genes: three (atf1 and atf2, encoding the diacylglycerol acyltransferase; pgpB, encoding the phosphatidic acid phosphatase) to complete the TAG biosynthesis pathway, and one gene (tadA) for lipid body assembly.
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Piracicaba, Brazil. In J Oral Pathol Med, Jun 2015
Moreover, MYB-NFIB and EWSR1-ATF1 gene fusions were shown to be specifically found in cases of adenoid cystic carcinomas and hyalinizing clear cell carcinomas, respectively, in the context of salivary gland tumors, becoming reliable diagnostic tools for these entities and potential therapeutic targets for future therapeutic protocols.