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Activating transcription factor 1

ATF1, Activating Transcription Factor 1
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: GDNF, CREB, EWS, CAN, V1a
Papers on ATF1
Regulation of the antioxidant system in cells of the fission yeast Schizosaccharomyces pombe after combined treatment with patulin and citrinin.
New
Pesti et al., Pécs, Hungary. In Toxicon, Feb 2016
The pattern of the ROS was the same as that induced by CTN (Máté et al., 2014), while the presence of PAT in the PAT+CTN combination treatment modified the activities of the antioxidant system (Papp et al., 2012) in comparison with the individual PAT or CTN treatment, suggesting toxin-specific regulation of glutathione and the enzymes of the antioxidant system and the possibility that the transcription factor (pap1 and atf1) -regulated processes might be influenced directly by ROS.
Metabolic engineering Corynebacterium glutamicum to produce triacylglycerols.
New
Sinskey et al., Cambridge, United States. In Metab Eng, Jan 2016
First, the plasmid pZ8_TAG4 was constructed which allows the heterologous expression of four genes: three (atf1 and atf2, encoding the diacylglycerol acyltransferase; pgpB, encoding the phosphatidic acid phosphatase) to complete the TAG biosynthesis pathway, and one gene (tadA) for lipid body assembly.
Integrated microfluidic approach for quantitative high-throughput measurements of transcription factor binding affinities.
New
Gerber et al., Ramat Gan, Israel. In Nucleic Acids Res, Jan 2016
Using QPID, we characterized the different affinities of ATF1, c-Jun, c-Fos and AP-1 to the CRE consensus motif and CRE half-site in two different genomic sequences on a single device.
Glabridin arrests cell cycle and inhibits proliferation of hepatocellular carcinoma by suppressing braf/MEK signaling pathway.
New
Huang et al., Dongguan, China. In Tumour Biol, Dec 2015
The experimental data showed that glabridin could inhibit the phosphorylation of MEK1/2 and the phosphorylation levels of downstream molecules including ERK1/2 and transcription factors ATF1 and CREB, but had no effect on the phosphorylation of braf.
Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
Review
New
Vargas et al., Piracicaba, Brazil. In J Oral Pathol Med, Jun 2015
Moreover, MYB-NFIB and EWSR1-ATF1 gene fusions were shown to be specifically found in cases of adenoid cystic carcinomas and hyalinizing clear cell carcinomas, respectively, in the context of salivary gland tumors, becoming reliable diagnostic tools for these entities and potential therapeutic targets for future therapeutic protocols.
Angiomatoid fibrous histiocytoma: the current status of pathology and genetics.
Review
New
Fisher et al., London, United Kingdom. In Arch Pathol Lab Med, May 2015
Angiomatoid fibrous histiocytoma is associated with 3 characteristic gene fusions, EWSR1-CREB1 and EWSR1-ATF1, which are also described in other neoplasms, and rarely FUS-ATF1.
Clear cell sarcoma-like tumor of the gastrointestinal tract: an evolving entity.
Review
New
Thway et al., London, United Kingdom. In Arch Pathol Lab Med, Mar 2015
The etiology of CCSLGT is unknown, but many studies have shown associations with EWSR1-CREB1 gene fusions and, less frequently, with EWSR1-ATF1 fusions.
Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells.
Lugnier et al., Illkirch-Graffenstaden, France. In Plos One, 2014
Delphinidin prevented VEGF-induced phosphorylation of ERK1/2 and p38 MAPK and decreased the expression of the transcription factors, CREB and ATF1.
Clear cell melanoma: a cutaneous clear cell malignancy.
Review
Harms et al., Ann Arbor, United States. In Arch Pathol Lab Med, 2014
Molecular studies demonstrated BRAF V600E mutation, copy gains at the 6p25 (RREB1) and 11q13 (CCND1) loci, and absence of EWSR1-ATF1 fusion.
Absence of 19 known hotspot oncogenic mutations in soft tissue clear cell sarcoma: two cases report with review of the literature.
Review
Li et al., Shihezi, China. In Int J Clin Exp Pathol, 2013
Reverse transcriptase-polymerase chain reaction (RT-PCR) results confirmed the presence of the EWS/ATF1 translocation (type 1) in the two cases.
Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics.
Impact
Capecchi et al., Salt Lake City, United States. In Cancer Cell, 2013
EWS-ATF1, the fusion product of a balanced chromosomal translocation between chromosomes 22 and 12, is considered the definitional feature of the tumor.
A measurable activation of the bZIP transcription factor Atf1 in a fission yeast strain devoid of stress-activated and cell integrity mitogen-activated protein kinase (MAPK) activities.
GeneRIF
Kuno et al., Kōbe, Japan. In J Biol Chem, 2012
Results suggest that Activation of Atf1 is not fully dependent on Sty1 and Pmk1.
Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status.
Review
GeneRIF
Fisher et al., London, United Kingdom. In Am J Surg Pathol, 2012
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions.
RNAi keeps Atf1-bound stress response genes in check at nuclear pores.
GeneRIF
Bühler et al., Basel, Switzerland. In Genes Dev, 2012
Dcr1 binds promoter regions and Atf1-bound genes at nuclear pores
Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection.
GeneRIF
Haskard et al., London, United Kingdom. In Circ Res, 2012
ATF-1 mediates HO-1 induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
MicroRNA-34c enhances murine male germ cell apoptosis through targeting ATF1.
GeneRIF
Cui et al., Beijing, China. In Plos One, 2011
miR-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling.
Impact
Arthur et al., Dundee, United Kingdom. In Nat Immunol, 2008
Deficiency in MSK1 and MSK2 prevented the binding of phosphorylated transcription factors CREB and ATF1 to the promoters of the genes encoding interleukin 10 and DUSP1.
Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers.
Impact
Fisher et al., Boston, United States. In Cancer Cell, 2006
Clear cell sarcoma (CCS) harbors a pathognomonic chromosomal translocation fusing the Ewing's sarcoma gene (EWS) to the CREB family transcription factor ATF1 and exhibits melanocytic features.
TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance.
Impact
Massagué et al., New York City, United States. In Cancer Cell, 2005
Repression of granzyme B and interferon-gamma involves binding of TGF-beta-activated Smad and ATF1 transcription factors to their promoter regions, indicating direct and selective regulation by the TGF-beta/Smad pathway.
RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins.
Impact
GeneRIF
Grewal et al., Bethesda, United States. In Science, 2004
Atf1 and Pcr1, two ATF/CREB family proteins, act in a parallel mechanism to the RNA interference pathway for heterochromatin nucleation
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