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Zinc finger homeobox 3

ATBF1, AT motif-binding factor 1, ZFHX3
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: RGS, AGE, AFP, ACID, HAD
Papers on ATBF1
Identification of Drosophila Zfh2 as a Mediator of Hypercapnic Immune Regulation by a Genome-Wide RNA Interference Screen.
Beitel et al., Evanston, United States. In J Immunol, Feb 2016
In vivo tests of one of the strongest screen hits, zinc finger homeodomain 2 (Zfh2; mammalian orthologs ZFHX3/ATBF1 and ZFHX4), demonstrate that reducing zfh2 function using a mutation or RNA interference improves survival of flies exposed to elevated CO2 and infected with Staphylococcus aureus.
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
International Stroke Genetics Consortium (ISGC) et al., In Lancet Neurol, Jan 2016
Our results also supported robust associations with ischaemic stroke for four other loci that have been reported in previous studies, including PITX2 (first stage OR 1·39, 1·29-1·49, p=3·26 × 10(-19); joint OR 1·37, 1·30-1·45, p=2·79 × 10(-32)) and ZFHX3 (first stage OR 1·19, 1·11-1·27, p=2·93 × 10(-7); joint OR 1·17, 1·11-1·23, p=2·29 × 10(-10)) for cardioembolic stroke, and HDAC9 (first stage OR 1·29, 1·18-1·42, p=3·50 × 10(-8); joint OR 1·24, 1·15-1·33, p=4·52 × 10(-9)) for large artery atherosclerosis stroke.
Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer.
Goodfellow et al., Saint Louis, United States. In J Natl Cancer Inst, Nov 2015
The chromosome 16q22 tumor suppressor genes CTCF and ZFHX3 are both frequently mutated in EEC, but their respective roles in outcome have not been determined.
Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor (ATBF1) Gene.
Lan et al., China. In Asian-australas J Anim Sci, Oct 2015
The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammalian growth and development.
Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.
Pak et al., Seoul, South Korea. In J Am Heart Assoc, Aug 2015
We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.
Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation.
Wang et al., Wuhan, China. In Plos Genet, Aug 2015
Among GWAS loci for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1.
The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.
Nolan et al., New York City, United States. In Cell, Aug 2015
We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3(Sci)), which accelerates circadian locomotor rhythms in mice.
Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis.
Dong et al., Atlanta, United States. In J Genet Genomics, Aug 2015
The phosphatase and tensin homolog (PTEN) and the zinc finger homeobox 3 (ZFHX3)/AT-motif binding factor 1 (ATBF1) genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia (mPIN) or tumor by their deletions in mouse prostates.
A complex insertion/deletion polymorphism in the compositionally biased region of the ZFHX3 gene in patients with coronary heart disease in a Chinese population.
Chen et al., Shenzhen, China. In Int J Clin Exp Med, 2014
Variants in ZFHX3 gene are associated with atrial fibrillation in individuals of European ancestry.
Detection of occult paroxysmal atrial fibrilation by implantable long-term electrocardiographic monitoring in cryptogenic stroke and transient ischemic attack population: a study protocol for prospective matched cohort study.
Sivák et al., Martin, Slovakia. In Bmc Cardiovasc Disord, 2014
The patients undergo long-term (12 months) ECG monitoring (implantable loop recorder) and testing for PITX2 (chromosome 4q25) and ZFHX3 (chromosome 16q22) gene mutations.
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
International Stroke Genetics Consortium et al., London, United Kingdom. In Lancet Neurol, 2012
FINDINGS: We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03×10(-12)).
Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.
Dong et al., Atlanta, United States. In Biochem J, 2012
Levels of ATBF1 protein in breast tumors are positively correlated with the levels of estrogen-responsive finger protein (EFP).
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
Markus et al., Oxford, United Kingdom. In Nat Genet, 2012
We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus.
Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells.
Dong et al., Atlanta, United States. In J Biol Chem, 2011
gen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells
Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.
Wang et al., Wuhan, China. In Hum Genet, 2011
Our results indicate that the s2106261 SNP in ZFHX3 confers a significant risk of atrial fibrillation in a Chinese Han population.
The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress.
Miura et al., Nagoya, Japan. In Dis Model Mech, 2010
A novel signaling pathway that links ATM via CREB to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta, is reported.
Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability.
Lee et al., In Pathology, 2009
Using DirectDNA sequencing analysis, we detected ATBF1, CYLD, PARK2 and WNT9A mutations in stomach and colorectal cancers
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
Witteman et al., Framingham, United States. In Nat Genet, 2009
Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) atrial fibrillation (AF) cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)).
Basic science and clinical research advances in the pituitary transcription factors: Pit-1 and Prop-1.
Ridgway et al., Aurora, United States. In Curr Opin Endocrinol Diabetes Obes, 2008
Among these findings include: the effects of the Pit-1 coactivators, GATA-2 and TRAP-220, on the transcriptional regulation of the TSHbeta gene and thyrotropin expression, characterization of a novel pituitary regulator of Pit-1 expression, Atbf1, elucidation of the roles of Wnt and Notch signaling on Prop-1-mediated specification of the Pit-1 cell lineage and gonadotropes, and the identification of regulatory regions of the Prop-1 gene.
Prevalent mutations in prostate cancer.
Dong, Atlanta, United States. In J Cell Biochem, 2006
These include the ELAC2 (HPC2), MSR1, and RNASEL (HPC1) genes that have germline mutations in familial prostate cancer; AR, ATBF1, EPHB2 (ERK), KLF6, mitochondria DNA, p53, PTEN, and RAS that have somatic mutations in sporadic prostate cancer; AR, BRCA1, BRCA2, CHEK2 (RAD53), CYP17, CYP1B1, CYP3A4, GSTM1, GSTP1, GSTT1, PON1, SRD5A2, and VDR that have germline genetic variants associated with either hereditary and/or sporadic prostate cancer; and ANXA7 (ANX7), KLF5, NKX3-1 (NKX3.1),
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