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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Angiotensin II receptor, type 2

AT2, angiotensin II type 2 receptor
receptor for angiotensin II; vasodilator that regulates many actions in vascular smooth muscle cells and during development [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Angiotensin II, AT1, Renin, V1a, CAN
Papers on AT2
Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.
Rice et al., London, United Kingdom. In Pain, Feb 2016
One notable exception is the angiotensin II type 2 (AT2) receptor that has clinical validity on the basis of a successful double-blind, randomized, placebo-controlled, clinical trial of EMA401, a highly selective, orally active, peripherally restricted AT2 receptor antagonist in patients with postherpetic neuralgia.
Hypercholesterolemia blunts the oxidative stress elicited by hypertension in venules through angiotensin II type-2 receptors.
Neil Granger et al., Shreveport, United States. In Microvasc Res, Feb 2016
CONCLUSIONS: These findings indicate that HCh blunts the oxidative stress and inflammatory cell recruitment elicited by hypertension in venules through a mechanism that involves AT2 receptor activation.
Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality.
Abadir et al., Baltimore, United States. In Aging (albany Ny), Jan 2016
Biological functions of angiotensin type 2 receptors (AT2R) are less studied.
Change of concept about the regulation of angiotensin II-induced monocyte chemoattractant protein-1 production in human endothelial cells.
Álvarez et al., Santiago de Compostela, Spain. In Vascul Pharmacol, Jan 2016
RESULTS: ANG-induced MCP-1 production was mediated by AT2 receptor, but not AT1 receptor in HUVECs in culture, which in turn activated NF-κB, promoting p65 subunit translocation to the nucleus.
Non-toxic O-quaternized chitosan materials with better water solubility and antimicrobial function.
Zhao et al., Yantai, China. In Int J Biol Macromol, Jan 2016
More importantly, their cytotoxicity was markedly lower than the corresponding QAS monomers by evaluating for AT2 cell line using CCK-8 assay.
Central Infusion of Angiotensin II Type 2 Receptor Agonist Compound 21 Attenuates DOCA/NaCl-Induced Hypertension in Female Rats.
He et al., Shenyang, China. In Oxid Med Cell Longev, Dec 2015
The present study investigated whether central activation of angiotensin II type 2 receptor (AT2-R) attenuates deoxycorticosterone acetate (DOCA)/NaCl-induced hypertension in intact and ovariectomized (OVX) female rats and whether female sex hormone status has influence on the effects of AT2-R activation.
The Role of Renin Angiotensin Aldosterone System Genes in Diabetic Nephropathy.
Rahimi, Kermānshāh, Iran. In Can J Diabetes, Dec 2015
Further, the concomitant study of both systemic and local RAAS, counter-regulators of ACE and ACE2, and also AT1R and angiotensin II type 2 receptor (AT2R) genes could help to elucidate the role of the genes of this system in the pathogenesis of DN.
Tissue Renin-Angiotensin System in Lacrimal Gland Fibrosis in a Murine Model of Chronic Graft-Versus-Host Disease.
Tsubota et al., Tokyo, Japan. In Cornea, Nov 2015
In addition, we characterize the inflammatory and fibrotic changes of the lacrimal gland in cGVHD model mice, demonstrate that fibroblasts strongly express angiotensin II, angiotensin II type 1 receptor (AT1R), and angiotensin II type 2 receptor, and show that mRNA expression of angiotensinogen increased in the lacrimal gland of cGVHD model mice.
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].
Thomas et al., Seychelles. In Pharmacol Rev, Oct 2015
The receptors for RAS peptides consist of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate angiotensin IV receptor (AngIV binding site).
Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects.
Yoshikawa, Kyoto, Japan. In Peptides, Oct 2015
Peptides showing anxiolytic-like antihypertensive and anti-alopecia effects via different types of receptors such as OT, FPR and AT2 were also obtained.
Molecular programs induced by heat acclimation confer neuroprotection against TBI and hypoxic insults via cross-tolerance mechanisms.
Shohami et al., Jerusalem, Israel. In Front Neurosci, 2014
Using mouse and rat acclimated phenotypes, we will focus on the impact of heat acclimation on Angiotensin II-AT2 receptors in neurogenesis and on HIF-1 as key mediators in spontaneous recovery and HANCT after traumatic brain injury (TBI).
The angiotensin II type 2 receptor for pain control.
Anand et al., Rotterdam, Netherlands. In Cell, 2014
provide a new chapter to the AT2 receptor story.
EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: a randomised, double-blind, placebo-controlled phase 2 clinical trial.
EMA401-003 study group et al., Rochester, United States. In Lancet, 2014
The angiotensin II type 2 receptor (AT2R) is a new target for neuropathic pain.
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Krasnow et al., Stanford, United States. In Nature, 2014
Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal, surfactant-secreting AT2 cells.
Hypoxic preconditioning induces an AT2-R/VEGFR-2(Flk-1) interaction in the neonatal brain microvasculature for neuroprotection.
Seltzer et al., Mendoza, Argentina. In Neuroscience, 2012
An interaction of the angiotensin II receptor subtype 2 (AT2-R) with vascular endothelial growth factor receptor 2 (VEGFR2) in the neonatal brain microvasculature that produces protective effects which are associated with injury tolerance.
Lack of association between C3123A polymorphism of the angiotensin II type 2 receptor gene and hypertension in Tunisian population.
Kaabachi et al., Tunis, Tunisia. In Tunis Med, 2012
In the present study, we showed that the 3123 C/A polymorphism of AGT2R gene is not a significant factor for hypertension in a sample of Tunisian population
Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.
Kobayashi et al., Tokyo, Japan. In Pharmacol Res, 2012
AT(2)R-mediated eNOS NO production and vasorelaxation through a MEK pathway are enhanced in aortas from db/db mice.
Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.
Zeng et al., Chongqing, China. In J Hypertens, 2012
results indicate that the renal AT(2) receptor, via nitric oxide/cGMP/Sp1 pathway, regulates AT(1 )receptor expression and function, which may be important in the regulation of sodium excretion and blood pressure
The involvement of angiotensin type 1 and type 2 receptors in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary.
Stepien et al., Łódź, Poland. In Scientificworldjournal, 2011
angiotensin type 1 and type 2 receptors are involved in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Dietz et al., Baltimore, United States. In Science, 2011
findings show loss of AT2 expression accelerates aberrant growth and rupture of the aorta in model of Marfan syndrome; AT2 signaling attenuates aortic aneurysm in mice through ERK1/2 antagonism
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