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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Angiotensin II, type I receptor-associated protein

AT1 receptor
Top mentioned proteins: AT1, Angiotensin II, Renin, V1a, AT2
Papers on AT1 receptor
Impact of Olmesartan Medoxomil on Amiodarone- Induced Pulmonary Toxicity in Rats: Focus on Transforming Growth Factor-ßeta-1.
New
Abd Allah et al., Banhā, Egypt. In Basic Clin Pharmacol Toxicol, Feb 2016
Several lines of evidence have suggested that AT1 receptor antagonists can attenuate pulmonary fibrosis in different animal models.
Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
New
Kimura et al., Chiba, Japan. In J Recept Signal Transduct Res, Feb 2016
To evaluate intrinsic potency of these RGS proteins, we compared inhibitory effects of RGS1, RGS2, RGS3, RGS4, RGS5, RGS8 and RGS16 on AT1 receptor signaling.
Up-regulation of the Ang II /AT1 receptor may compensate for the loss of gastric antrum ICC via the PI3k/Akt signaling pathway in STZ-induced diabetic mice.
New
Xu et al., Shanghai, China. In Mol Cell Endocrinol, Feb 2016
However, the angiotensin receptor type 1 (AT1R) expression levels in gastric smooth muscle and angiotensin-converting enzyme (ACE) expression levels in gastric mucosa were increased.
Combined Angiotensin Receptor Modulation in the Management of Cardio-Metabolic Disorders.
Review
New
Unger et al., Maastricht, Netherlands. In Drugs, Jan 2016
Consequently, RAS inhibition by ACE inhibitors or angiotensin AT1 receptor (AT1R) blockers is the evidence-based standard for cardiovascular risk reduction in high-risk patients, including diabetics with albuminuria.
Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells.
New
Kim et al., Suwŏn, South Korea. In Korean J Intern Med, Jan 2016
RESULTS: Ang III increased MCP-1 protein production in dose- and time-dependent manners in HK-2 cells, which was inhibited by the AT1 receptor blocker losartan.
Change of concept about the regulation of angiotensin II-induced monocyte chemoattractant protein-1 production in human endothelial cells.
New
Álvarez et al., Santiago de Compostela, Spain. In Vascul Pharmacol, Jan 2016
RESULTS: ANG-induced MCP-1 production was mediated by AT2 receptor, but not AT1 receptor in HUVECs in culture, which in turn activated NF-κB, promoting p65 subunit translocation to the nucleus.
Role of the Renin-Angiotensin-Aldosterone System and Its Pharmacological Inhibitors in Cardiovascular Diseases: Complex and Critical Issues.
Review
New
SIF Task Force et al., Bologna, Italy. In High Blood Press Cardiovasc Prev, Dec 2015
In the last years, however, several notions on the RAS have been improved by the results of large, randomized clinical trials, performed in different clinical settings and in different populations treated with RAS inhibiting drugs, including angiotensin converting enzyme (ACE) inhibitors and antagonists of the AT1 receptor for angiotensin II (ARBs).
Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress.
Review
New
Santos et al., Belo Horizonte, Brazil. In Neuropeptides, Nov 2015
Recent data indicate that the activation of angiotensin-converting enzyme/angiotensin II/AT1 receptor axis facilitates the emotional stress responses.
From bedside to bench-meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015.
Review
New
Seifert et al., Würzburg, Germany. In Naunyn Schmiedebergs Arch Pharmacol, Nov 2015
The combination of neprilysin inhibitors-enhancing stimulation of the particulate guanylate cyclase pathway by preventing natriuretic peptide degradation-with angiotensin AT1 receptor antagonists constitutes a novel promising strategy for heart failure treatment.
International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].
Review
New
Impact
Thomas et al., Seychelles. In Pharmacol Rev, Oct 2015
The receptors for RAS peptides consist of three G-protein-coupled receptors—the angiotensin II type 1 receptor (AT1 receptor), the angiotensin II type 2 receptor (AT2 receptor), the MAS receptor—and a type II trans-membrane zinc protein—the candidate angiotensin IV receptor (AngIV binding site).
Regulation of TRPC6 ion channels in podocytes - Implications for focal segmental glomerulosclerosis and acquired forms of proteinuric diseases.
Review
New
Bíró et al., Debrecen, Hungary. In Acta Physiol Hung, Sep 2015
Angiotensin II, acting through its AT1 receptor, plays a critical role in generation of proteinuria and progression of kidney injury in a number of kidney diseases, including FSGS.
The angiotensin II type 2 receptor for pain control.
Impact
Anand et al., Rotterdam, Netherlands. In Cell, 2014
This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease.
Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium.
GeneRIF
Wieland et al., Mannheim, Germany. In Cell Signal, 2012
Angiotensin II modulates Vegf-induced angiogenesis through opposing effects of angiotensin II receptor type 1 and type 2.
Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells.
GeneRIF
Watanabe et al., Tokorozawa, Japan. In Biochem Biophys Res Commun, 2012
These results suggest that the stimulation of mouse iPS cells with AT(1)R may enhance LIF-induced DNA synthesis, by augmenting the generation of superoxide and activating JAK/STAT3, and that AT(1)R stimulation may enhance Col IV-induced differentiation into mesodermal progenitor cells via p38 MAPK activation.
Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice.
GeneRIF
Liu et al., Chengdu, China. In J Renin Angiotensin Aldosterone Syst, 2012
Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R.
Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors.
GeneRIF
Touyz et al., Ottawa, Canada. In Hypertension, 2011
Findings suggest that adipocyte-derived factors regulate VSMC function through specific MAPKs linked to MR, GR, and AT(1)R, a posttranslational phenomenon.
Involvement of Runx3 in the basal transcriptional activation of the mouse angiotensin II type 1 receptor-associated protein gene.
GeneRIF
Umemura et al., Yokohama, Japan. In Physiol Genomics, 2011
Runx3 plays a role in ATRAP gene expression in renal distal tubular cells both in vitro and in vivo.
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism.
Impact
Dietz et al., Baltimore, United States. In Science, 2011
The selective AT1 receptor blocker (ARB) losartan abrogated aneurysm progression in the mice; full protection required intact AT2 signaling.
The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease.
Review
Impact
Nishiyama et al., New Orleans, United States. In Pharmacol Rev, 2007
Moreover, circulating Ang II is actively internalized into proximal tubular cells by AT1 receptor-dependent mechanisms.
The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure.
Review
Impact
Paiva et al., São Paulo, Brazil. In Physiol Rev, 2007
The most prevalent physiological effects of ANG II, the main product of the renin-angiotensin system, are mediated by the AT1 receptor, a rhodopsin-like AGPCR.
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