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Sperm associated antigen 5

Astrin, Deepest, Spag5
This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, ACID, Odf2
Papers on Astrin
The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division.
Torres et al., Los Angeles, United States. In Cell Rep, Feb 2016
We show that astrin, a microtubule-organizing protein, co-purifies with Mid1 and Mid2, has an overlapping localization with Mid1 and Mid2 at intercellular bridge microtubules, is ubiquitinated by Mid2 on lysine 409, and is degraded during cytokinesis.
Salmon Gill Poxvirus, the Deepest Representative of the Chordopoxvirinae.
Dale et al., Bethesda, United States. In J Virol, Sep 2015
Phylogenomic analyses showed that the fish poxvirus is the deepest available branch of chordopoxviruses.
Circumferential cryoablation in a strictured esophagus: a feasibility and dose-finding study in a porcine model after inducing stenosis by endoscopic mucosal resection.
Weusten et al., Nieuwegein, Netherlands. In Dis Esophagus, Sep 2015
Deepest ablation effects were seen at the center of the resection-induced scar.
Applying "Lasso" Regression to Predict Future Visual Field Progression in Glaucoma Patients.
Asaoka et al., In Invest Ophthalmol Vis Sci, Apr 2015
For each patient, the mean of all total deviation values (mTD) in the 10th VF was predicted using varying numbers of prior VFs (ranging from the first three VFs to all previous VFs) by applying ordinary least squares linear regression (OLSLR), M-estimator robust regression (M-robust), MM-estimator robust regression (MM-robust), skipped regression (Skipped), deepest regression (Deepest), and Lasso regression.
Comparative analysis of testis transcriptomes from triploid and fertile diploid cyprinid fish.
Liu et al., Changsha, China. In Biol Reprod, Apr 2015
A series of genes (DNAHs, DNAL1, IFTs, and DNAAF1) associated with sperm flagellar assembly and motility, and testis-specific candidate markers (Tcte1, Tekt1, Tekt4, Spag17, Spag5, Spag9a, Spag1b, and Spef2), had low expression levels in the testis of triploid fish.
Protein deep sequencing applied to biobank samples from patients with pancreatic cancer.
Marko-Varga et al., Lund, Sweden. In J Cancer Res Clin Oncol, Feb 2015
Pancreatic disease link associations could be made for BAZ2A, CDK13, DAPK1, DST, EXOSC3, INHBE, KAT2B, KIF20B, SMC1B, and SPAG5, by pathway network linkages to p53, the most frequently altered tumor suppressor in pancreatic cancer.
A Fast Algorithm to Estimate the Deepest Points of Lakes for Regional Lake Registration.
Luo et al., Beijing, China. In Plos One, 2014
This paper defines a process to estimate the deepest points of lakes as the most stable ground control points for registration.
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
Reiter et al., San Francisco, United States. In Elife, 2014
MCPH proteins interact with distinct centriolar satellite proteins; CDK5RAP2 interacts with SPAG5 and CEP72, CEP152 with CEP131, WDR62 with MOONRAKER, and CEP63 with CEP90 and CCDC14.
A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset.
Draviam et al., Groningen, Netherlands. In Biol Open, 2014
We show that the interaction of EB1 with Astrin-SKAP complex, a key regulator of chromosome segregation, is enhanced during prometaphase, compared to anaphase.
Molecular systematics and morphological identification of the cryptic species of the genus Acalles Schoenherr, 1825, with descriptions of new species (Coleoptera: Curculionidae: Cryptorhynchinae).
Stüben et al., Bonn, Germany. In Zootaxa, 2014
(formerly Acalles edoughensis) from North Africa and Spain change to Coloracalles Astrin & Stüben, 2008 and Pseudodichromacalles xerampelinus Wollaston, 1864 comb.
The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation.
Yu et al., Taiwan. In Am J Physiol Cell Physiol, 2014
Astrin regulates several aspects of mitosis, such as maintaining the cohesion of sister chromatids by inactivating Separase and stabilizing spindle, aligning and segregating chromosomes, and silencing spindle assembly checkpoint by interacting with Src kinase-associated phosphoprotein (SKAP) and cytoplasmic linker-associated protein-1α (CLASP-1α).
OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.
Yan et al., Guangzhou, China. In Exp Cell Res, 2014
Here, a yeast two-hybrid screen identified Homo sapiens sperm associated antigen 5 (SPAG5)/Astrin as interaction partner of ORP8.
SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway.
Zheng et al., Guangzhou, China. In Cell Death Dis, 2013
Previously, we found that sperm-associated antigen 5 (SPAG5) was upregulated in pelvic lymph node metastasis-positive cervical cancer.
2012 best practices for repositories collection, storage, retrieval, and distribution of biological materials for research international society for biological and environmental repositories.
In Biopreserv Biobank, 2012
Skubitz, PhD Stella B. Somiari, PhD Individual Contributors to the Third Edition Jonas Astrin, Susan Baker, Thomas J. Barr, Erica Benson, Mark Cada, Lori Campbell, Antonio Hugo Jose Froes Marques Campos, David Carpentieri, Omoshile Clement, Domenico Coppola, Yvonne De Souza, Paul Fearn, Kelly Feil, Debra Garcia, Judith Giri, William E. Grizzle, Kathleen Groover, Keith Harding, Edward Kaercher, Joseph Kessler, Sarah Loud, Hannah Maynor, Kevin McCluskey, Kevin Meagher, Cheryl Michels, Lisa Miranda, Judy Muller-Cohn, Rolf Muller, James O'Sullivan, Karen Pitt, Rebecca Pugh, Rivka Ravid, Katherine Sexton, Ricardo Luis A. Silva, Frank Simione, Amy Skubitz, Stella Somiari, Frans van der Horst, Gavin Welch, Andy Zaayenga 2012 Best Practices for Repositories: Collection, Storage, Retrieval and Distribution of Biological Materials for Research INTERNATIONAL SOCIETY FOR BIOLOGICAL AND ENVIRONMENTAL REPOSITORIES (ISBER) INTRODUCTION T he availability of high quality biological and environmental specimens for research purposes requires the development of standardized methods for collection, long-term storage, retrieval and distribution of specimens that will enable their future use.
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.
Compton et al., United States. In Embo J, 2010
Data show that CLASP1-astrin-Kif2b complex acts as a central switch at kinetochores that defines mitotic progression and promotes fidelity by temporally regulating kinetochore-microtuble attachments.
SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint.
Legerski et al., Houston, United States. In Cell Cycle, 2009
Results suggest that SNM1B/Apollo and Astrin function together to enforce the prophase checkpoint in response to spindle stress.
Astrin regulates Aurora-A localization.
Hannon et al., United States. In Biochem Biophys Res Commun, 2008
Astrin acts upstream of Aurora-A to regulate its mitotic spindle localization.
Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin.
Hong et al., Kao-hsiung, Taiwan. In J Biol Chem, 2008
GSK3beta interacts with and phosphorylates the spindle-associated protein Astrin, resulting in targeting Astrin to the spindle microtubules and kinetochores.
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity.
Gruneberg et al., Martinsried, Germany. In J Cell Biol, 2007
Results report that depletion of the microtubule and kinetochore protein astrin results in checkpoint-arrested cells with multipolar spindles and separated sister chromatids, which is consistent with untimely separase activation.
Deepest known plant life discovered on an uncharted seamount.
Norris et al., In Science, 1985
The discovery of abundant autotrophic macrophytes living below 200 meters indicates their importance to primary productivity, food webs, sedimentary processes, and as reef builders in clear oceanic waters.
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