Identification of a novel PARP14-TFE3 gene fusion from 10-year-old FFPE tissue by RNA-seq.
Hackensack, United States. In Genes Chromosomes Cancer, Jun 2015
To date, five partner genes have been identified, that is, PRCC in 1q21, PSF in 1q34, ASPL in 17q25, CLTC in 17q23, and NONO in Xq12; and three additional translocations have been reported with no partner gene being defined: t(X;3)(p11;q23), t(X;10)(p11;q23), and t(X;19)(p11;q13).
Distinctive pathways characterize A. actinomycetemcomitans and P. gingivalis.
Harbin, China. In Mol Biol Rep, Feb 2015
Network topological features of A. actinomycetemcomitans-related and P. gingivalis-related protein-protein interaction networks, and background network, which included average shortest path length (ASPL), degree, closeness centrality (CC), eccentricity (EC), betweenness centrality (BC) and topological coefficient (TC) were compared using network analysis plugin of Cytoscape, followed by pathway enrichment analysis (p value <0.05) using FISHER hyper-geometric algorithm and calculation of pathway alter scores using LIMMA.
Xp11 translocation renal cell carcinoma.
Baltimore, United States. In Pathology, 2010
The resulting gene fusions involve the TFE3 transcription factor gene and multiple reported genes, including the same one (ASPL) found in the characteristic gene fusion of alveolar soft part sarcoma.
International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature.
Cambridge, United Kingdom. In Pharmacol Rev, 2002
A selective ET(A) receptor agonist has not been discovered, but highly selective antagonists include peptides (BQ123, cyclo-[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-]; FR139317, N- [(hexahydro-1-azepinyl)carbonyl]L-Leu(1-Me)D-Trp-3 (2-pyridyl)-D-Ala) and the generally more potent nonpeptides, such as PD156707, SB234551, L754142, A127722, and TBC11251.