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MSD1 Msd1p

Aspartate-tRNA Ligase, AspRS, DRS1
Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, STEP, SET, glutaminyl-tRNA synthetase
Papers on Aspartate-tRNA Ligase
Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis.
New
Yao et al., Sapporo, Japan. In Proc Natl Acad Sci U S A, Feb 2015
This conversion involves two enzymes: a nondiscriminating aspartyl-tRNA synthetase (ND-AspRS) that forms Asp-tRNA(Asn), and a heterotrimeric amidotransferase GatCAB that amidates Asp-tRNA(Asn) to form Asn-tRNA(Asn) for use in protein synthesis.
Crystallization and preliminary X-ray crystallographic analysis of a bacterial Asn-transamidosome.
Yao et al., Sapporo, Japan. In Acta Crystallogr Sect F Struct Biol Commun, 2014
In this study, the Asn-transamidosome from Pseudomonas aeruginosa was reconstructed and crystallized by mixing purified GatCAB complex, AspRS and tRNA(Asn).
Relaxed tRNA specificity of the Staphylococcus aureus aspartyl-tRNA synthetase enables RNA-dependent asparagine biosynthesis.
Sheppard et al., Saratoga Springs, United States. In Febs Lett, 2014
The S. aureus genome also codes for one aspartyl-tRNA synthetase (AspRS).
Released selective pressure on a structural domain gives new insights on the functional relaxation of mitochondrial aspartyl-tRNA synthetase.
Sissler et al., Strasbourg, France. In Biochimie, 2014
This is also the case for human mitochondrial aspartyl-tRNA synthetase (AspRS) that shares the so-called bacterial insertion domain with bacterial homologs.
Architecture and metamorphosis.
Review
Yang et al., Jupiter, United States. In Top Curr Chem, 2013
The human MSC consists of nine aaRSs (LysRS, ArgRS, GlnRS, AspRS, MetRS, IleRS, LeuRS, GluProRS, and bifunctional aaRs) and three scaffold proteins (AIMP1/p43, AIMP2/p38, and AIMP3/p18), and has a molecular weight of 1.5 million Dalton.
Influence of Acetobacter pasteurianus SKU1108 aspS gene expression on Escherichia coli morphology.
Theeragool et al., Bangkok, Thailand. In J Microbiol, 2013
The aspS gene encoding Aspartyl-tRNA synthetase (AspRS) from a thermotolerant acetic acid bacterium, Acetobacter pasteurianus SKU1108, has been cloned and characterized.
Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA.
GeneRIF
Scheper et al., Amsterdam, Netherlands. In Biochem J, 2012
Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA.
Leukoencephalopathy with brainstem and spinal cord involvement caused by a novel mutation in the DARS2 gene.
GeneRIF
Bindoff et al., Bergen, Norway. In J Neurol, 2012
We describe two new cases of Leukoencephalopathy with brainstem and spinal cord involvement and elevated lactate with a novel pathogenic mutation in the DARS2 gene
Acetazolamide-responsive exercise-induced episodic ataxia associated with a novel homozygous DARS2 mutation.
GeneRIF
Schöls et al., Tübingen, Germany. In J Med Genet, 2011
Case demonstrates that DARS2 mutation homozygosity is not lethal, as suggested earlier, but compatible with a rather benign disease course.
A novel homozygous mutation of DARS2 may cause a severe LBSL variant.
GeneRIF
Matsumoto et al., In Clin Genet, 2011
A novel homozygous mutation of DARS2 may cause a severe LBSL (Leukoencephalopathy with brain stem and spinal cord involvement with lactate elevation) variant.
A human pathology-related mutation prevents import of an aminoacyl-tRNA synthetase into mitochondria.
GeneRIF
Sissler et al., Strasbourg, France. In Biochem J, 2011
Mutations in the nuclear gene coding for the mitochondrial aspartyl-tRNA synthetase, a key enzyme for mitochondrial translation, are correlated with leukoencephalopathy
Rational association of genes with traits using a genome-scale gene network for Arabidopsis thaliana.
Impact
Rhee et al., Seoul, South Korea. In Nat Biotechnol, 2010
By interrogating network neighborhoods, we identify AT1G80710 (now DROUGHT SENSITIVE 1; DRS1) and AT3G05090 (now LATERAL ROOT STIMULATOR 1; LRS1) as regulators of drought sensitivity and lateral root development, respectively.
From conventional crystallization to better crystals from space: a review on pilot crystallogenesis studies with aspartyl-tRNA synthetases.
Review
Giegé et al., Strasbourg, France. In Acta Crystallogr D Biol Crystallogr, 2002
With AspRS from Thermus thermophilus, the better crystalline quality of the space-grown crystals within APCF is correlated with higher quality of the derived electron density maps.
TnAraOut, a transposon-based approach to identify and characterize essential bacterial genes.
Impact
Mekalanos et al., Boston, United States. In Nat Biotechnol, 2000
Of a total of 16 arabinose-dependent TnAraOut mutants characterized in Vibrio cholerae, four were found to carry insertions upstream of known essential genes (gyrB, proRS, ileRS, and aspRS) whereas the other strains carried insertions upstream of known and hypothetical genes not previously shown to encode essential gene products.
Biomaterials in the face: benefits and risks.
Review
Persing et al., Milwaukee, United States. In J Craniofac Surg, 1999
The symposium was held in Boston, MA, immediately preceding the 1998 annual meeting of the ASPRS/PSEF.
Analysis of methods for reporting severe and mortal lipoplasty complications.
Review
Rockwell et al., New York City, United States. In Aesthetic Plast Surg, 1999
From these and from ASPRS questionnaire surveys of experienced, board-certified plastic surgeons, it is apparent that (1) plastic surgeons do not often voluntarily report severe and mortal complications (either as case reports or in self-reported series), and (2) while survey studies provide the most accurate estimate of complications due to lipoplasty, they are subject to an underreporting bias because they exclude complications occurring in the hands of residents and junior attendings.
Yeast tRNA(Asp) recognition by its cognate class II aminoacyl-tRNA synthetase.
Impact
Moras et al., Strasbourg, France. In Nature, 1993
The five aminoacyl-tRNA synthetases whose crystal structures are known (MetRS, TyrRS and GlnRS in class I, SerRS and AspRS in class II) belong to different subgroups.
Recognition of tRNAs by aminoacyl-tRNA synthetases.
Review
Moras et al., Strasbourg, France. In Faseb J, 1993
The interaction between the acceptor end and the active site domain is class-specific and the binding mode of the stem observed in the crystal structures of GlnRS-tRNA(Gln) and AspRS-tRNA(Asp) complexes can be generalized to their respective classes.
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.
Impact
Moras et al., Strasbourg, France. In Nature, 1990
These three latter aaRS share three new sequence motifs with AspRS, AsnRS, LysRS, HisRS and the beta subunit of PheRS.
Current status of liquid injectable silicone.
Goulian, New York City, United States. In Aesthetic Plast Surg, 1978
This was done with the cooperation of the American Society of Plastic and Reconstructive Surgeons and was submitted for approval by the FDA along with an expanded group of clinical investigators selected with the help of the ASPRS, with consideration given to their even geographic distribution.
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