Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
Boston, United States. In Science, 2013
mTORC1 signaling posttranslationally regulated this metabolic pathway via its downstream target ribosomal protein S6 kinase 1 (S6K1), which directly phosphorylates S1859 on CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, dihydroorotase), the enzyme that catalyzes the first three steps of de novo pyrimidine synthesis.
Contribution of CDP/Cux, a transcription factor, to cell cycle progression.
Suzhou, China. In Acta Biochim Biophys Sin (shanghai), 2007
The generation of CDP/Cux p110 stimulates the expression of reporter plasmid containing the promoter sequences of some S phase-specific-genes such as DNA polymerase a gene, dihydrofolate reductase gene, carbamoyl-phosphate synthase/aspartate carbamoyl-transferase/dihydroorotase gene, and cyclin A gene.
Studies on the mechanism of RNAi-dependent heterochromatin assembly.
Boston, United States. In Cold Spring Harb Symp Quant Biol, 2005
In support of this possibility, tethering of the RITS complex to the transcript of the normally euchromatic ura4 (+) gene results in siRNA generation and RNAi- and heterochromatin-dependent silencing of the ura4 (+) gene.