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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 May 2015.

Glutamic-oxaloacetic transaminase 2, mitochondrial

aspartate aminotransferase, FABPpm, mAAT
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, AGE, Serum albumin
Papers using aspartate aminotransferase antibodies
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
Supplier
Yang J et al., In Cancer Gene Therapy, 2003
... The mouse alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme-linked immunosorbent assay (ELISA) kits were purchased from Uscn Life Science (Wuhan, China) ...
Papers on aspartate aminotransferase
Aspartate aminotransferase and free thyroid hormones in vaginal washing fluid as markers for preterm pre-labor rupture of membranes.
New
Elkashif et al., Cairo, Egypt. In J Obstet Gynaecol Res, 25 Jun 2015
AIM: To evaluate the diagnostic value of vaginal fluid aspartate aminotransferase (AST), free triiodothyronine (T3 ) and free thyroxine (T4 ) in women with preterm pre-labor rupture of membranes (PPROM).
Methane Attenuates Hepatic Ischemia-Reperfusion Injury in Rats through Anti-apoptosis, Anti-inflammatory and Anti-oxidative.
New
Sun et al., Nantong, China. In Shock, 22 Jun 2015
We found that methane-rich saline significantly decreased serum alanine aminotransferase, aspartate aminotransferase activity and the occurrence of necrosis.
Transient elastography using Fibroscan is the most reliable noninvasive method for the diagnosis of advanced fibrosis and cirrhosis in alcoholic liver disease.
New
Moreno et al., Brussels, Belgium. In Eur J Gastroenterol Hepatol, 18 Jun 2015
The aims of this study were as follows: (a) to compare the performance of FS and different biochemical markers in ALD patients; (b) to assess the best FS cut-off values for the prediction of fibrosis stage in our ALD population; and (c) to assess the influence of aspartate aminotransferase (AST) values on FS.
A new scheme with infusion of hepatitis B immunoglobulin combined with entecavir for prophylaxis of hepatitis B virus recurrence among liver transplant recipients.
New
Li et al., Kunming, China. In Eur J Gastroenterol Hepatol, 18 Jun 2015
The suppressed HBV recurrence was associated with significantly lower serum alanine aminotransferase and aspartate aminotransferase in the new protocol-treated patients tested at 1 month and 1 week after liver surgery compared with those treated with the European protocol.
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, 13 Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.
New
Impact
MITO 11 investigators et al., Napoli, Italy. In Lancet Oncol, 31 May 2015
The most common grade 3-4 adverse events were neutropenia (11 [30%] in the pazopanib group vs one [3%] in the paclitaxel group), fatigue (four [11%] vs two [6%]), leucopenia (four [11%] vs one [3%]), hypertension (three [8%] vs none [0%]), raised aspartate aminotransferase or alanine aminotransferase (three [8%] vs none), and anaemia (two [5%] vs five [14%]).
Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
Review
New
Xiao et al., Chengdu, China. In J Ethnopharmacol, 04 May 2015
The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL).
Hepatoprotective effects of a self-micro emulsifying drug delivery system containing Silybum marianum native seed oil against experimentally induced liver injury.
New
Bácskay et al., In Pharmazie, 30 Apr 2015
Determination of alanine aminotransferase (ALT), aspartate aminotransferase (AST) levels and also liver histology investigations have been done.
Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial.
New
Impact
Penel et al., Villejuif, France. In Lancet Oncol, Mar 2015
The most common grade 3 and 4 toxicities were alanine aminotransferase or aspartate aminotransferase increases (one [4%] in the interruption group vs three [14%] in the continuation group), neutropenia (two [8%] vs two [10%]), and intestinal occlusion (one [4%] vs one [5%]).
Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis.
Review
New
Yan et al., Chengdu, China. In Hepatology, Jan 2015
UNLABELLED: The aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on the four factors (Fibrosis 4 index; FIB-4) are the two most widely studied noninvasive tools for assessing liver fibrosis.
Clinical illness and outcomes in patients with Ebola in Sierra Leone.
New
Impact
WHO Clinical Response Team et al., Aş Şanamayn, Syria. In N Engl J Med, Dec 2014
Clinical and laboratory factors at presentation that were associated with a fatal outcome included fever, weakness, dizziness, diarrhea, and elevated levels of blood urea nitrogen, aspartate aminotransferase, and creatinine.
All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.
New
Impact
HALLMARK-DUAL Study Team et al., Hannover, Germany. In Lancet, Dec 2014
Serious adverse events occurred in 12 (6%) patients in the treatment-naive group; 11 (5%) non-responders, and 16 (7%) ineligible, intolerant, or ineligible and intolerant patients; adverse events leading to discontinuation (most commonly reversible increases in alanine or aspartate aminotransferase) occurred in six (3%), two (1%), and two (1%) patients, respectively, with no deaths recorded.
[A family with two children diagnosed with aspartylglucosaminuria-case report and literature review].
Review
New
Chen et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Jun 2014
Blood biochemistry showed alanine aminotransferase 67.1 U/L, aspartate aminotransferase 74.1 U/L, serum albumin 32.8 g/L, direct bilirubin 10.5 µmol/L, lactate dehydrogenase 301.7 U/L.
Androgens for the anaemia of chronic kidney disease in adults.
Review
Wu et al., Seoul, South Korea. In Cochrane Database Syst Rev, 2013
The small number of included studies, and low participant numbers adversely influenced evidence quality overall.We found limited evidence (1 study, 24 participants) to indicate that oxymetholone can increase haemoglobin (Hb) (MD 1.90 g/dL, 95% CI 1.66 to 2.14), haematocrit (HCT) (MD 27.10%, 95% CI 26.49 to 27.71), change in albumin (MD 4.91 g/L, 95% CI 3.69 to 6.13), alanine aminotransferase (ALT) (MD 54.50 U/L, 95% CI 43.94 to 65.06), and aspartate aminotransferase (AST) (MD 47.33 U/L, 95% CI 37.69 to 56.97); and decrease high-density lipoprotein (HDL) (MD -15.66 mg/dL, 95% CI -24.84 to -6.48).
Methotrexate for induction of remission in ulcerative colitis.
Review
McDonald et al., London, Canada. In Cochrane Database Syst Rev, 2013
Adverse events experienced by methotrexate patients in the active comparator study included nausea and dyspepsia, mild alopecia, mild increase in aspartate aminotransferase levels, peritoneal abscess, hypoalbuminemia, severe rash and atypical pneumonia.
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
GeneRIF
Hamilton et al., Boston, United States. In Biophys J, 2012
The lipid binding process in L-FABP is associated with backbone dynamics.
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
GeneRIF
Li et al., Blacksburg, United States. In Biosci Rep, 2011
The role of mAspAT in vivo is to control the levels of endogenous kynurenic acid (KYNA) through modulation of the mAspAt in the mouse brain.
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
GeneRIF
Du et al., Beijing, China. In Lab Invest, 2011
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
GeneRIF
Li et al., Blacksburg, United States. In Bmc Biochem, 2009
KAT IV inhibited by equimolar tryptophan and aspartate, and half-life is 6.5 minutes at 65 degree C.
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle.
GeneRIF
Winnicka et al., Białystok, Poland. In J Physiol Pharmacol, 2008
FAT/CD36 and FABPpm protein content was increased in red muscles in IL-6(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG).
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