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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 16 Apr 2015.

Glutamic-oxaloacetic transaminase 2, mitochondrial

aspartate aminotransferase, FABPpm, mAAT
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, AGE, CAN, Serum albumin
Papers using aspartate aminotransferase antibodies
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
Supplier
Yang J et al., In Cancer Gene Therapy, 2003
... The mouse alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme-linked immunosorbent assay (ELISA) kits were purchased from Uscn Life Science (Wuhan, China) ...
Papers on aspartate aminotransferase
Indirect estimation of pediatric between-individual biological variation data for 22 common serum biochemistries.
New
Metz et al., Singapore, Singapore. In Am J Clin Pathol, 31 May 2015
RESULTS: The CVg was generally higher during the first year of life and declined to reach a constant level by age 4 to 6 years, except for aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, and phosphate.
Hepatoprotective effect of a polysaccharide from Crassostrea gigas on acute and chronic models of liver injury.
New
Li et al., Dalian, China. In Int J Biol Macromol, 10 May 2015
Treatment with CGPS-1 decreased serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), and malondialdehyde aldehyde (MDA) levels; increased superoxide dismutase (SOD) activity; and improved hepatic injury in both the acute and chronic models of liver injury in mice.
Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
Review
New
Xiao et al., Chengdu, China. In J Ethnopharmacol, 04 May 2015
The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL).
Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial.
New
Impact
Penel et al., Villejuif, France. In Lancet Oncol, 31 Mar 2015
The most common grade 3 and 4 toxicities were alanine aminotransferase or aspartate aminotransferase increases (one [4%] in the interruption group vs three [14%] in the continuation group), neutropenia (two [8%] vs two [10%]), and intestinal occlusion (one [4%] vs one [5%]).
Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection: a systemic review and meta-analysis.
Review
New
Yan et al., Chengdu, China. In Hepatology, Jan 2015
UNLABELLED: The aspartate aminotransferase-to-platelet ratio index (APRI) and fibrosis index based on the four factors (Fibrosis 4 index; FIB-4) are the two most widely studied noninvasive tools for assessing liver fibrosis.
[The experience of applying system of continuous monitoring of content of glucose in children with glycogen disease].
New
In Klin Lab Diagn, Jan 2015
In primary patients as compared with secondary patients rate and duration of hypoglycemia in blood serum activity of aspartate aminotransferase also was reliably higher.
Exercise training and calorie restriction influence the metabolic parameters in ovariectomized female rats.
New
Varga et al., Szeged, Hungary. In Oxid Med Cell Longev, Dec 2014
The metabolic syndrome was assessed by measuring the body weight gain, the glucose sensitivity, and the levels of insulin, triglyceride, leptin, and aspartate aminotransferase transaminase (AST) and alanine aminotransferase (ALT).
Hyponatremia in hepatocellular carcinoma complicating with cirrhosis.
New
Osaki et al., Ōsaka, Japan. In J Cancer, Dec 2014
aspartate aminotransferase ≥57 IU/L (P=0.002),
Clinical illness and outcomes in patients with Ebola in Sierra Leone.
New
Impact
WHO Clinical Response Team et al., Aş Şanamayn, Syria. In N Engl J Med, Dec 2014
Clinical and laboratory factors at presentation that were associated with a fatal outcome included fever, weakness, dizziness, diarrhea, and elevated levels of blood urea nitrogen, aspartate aminotransferase, and creatinine.
All-oral daclatasvir plus asunaprevir for hepatitis C virus genotype 1b: a multinational, phase 3, multicohort study.
New
Impact
HALLMARK-DUAL Study Team et al., Hannover, Germany. In Lancet, Dec 2014
Serious adverse events occurred in 12 (6%) patients in the treatment-naive group; 11 (5%) non-responders, and 16 (7%) ineligible, intolerant, or ineligible and intolerant patients; adverse events leading to discontinuation (most commonly reversible increases in alanine or aspartate aminotransferase) occurred in six (3%), two (1%), and two (1%) patients, respectively, with no deaths recorded.
Oral 9-cis retinoid for childhood blindness due to Leber congenital amaurosis caused by RPE65 or LRAT mutations: an open-label phase 1b trial.
New
Impact
Saperstein et al., Montréal, Canada. In Lancet, Nov 2014
No serious adverse events occurred, although we noted transient headaches (11 patients), photophobia (11 patients), reduction in serum HDL concentrations (four patients), and increases in serum triglycerides (eight patients) and aspartate aminotransferase concentrations (two patients).
[A family with two children diagnosed with aspartylglucosaminuria-case report and literature review].
Review
New
Chen et al., Beijing, China. In Zhonghua Er Ke Za Zhi, Jun 2014
Blood biochemistry showed alanine aminotransferase 67.1 U/L, aspartate aminotransferase 74.1 U/L, serum albumin 32.8 g/L, direct bilirubin 10.5 µmol/L, lactate dehydrogenase 301.7 U/L.
Definitive chemoradiotherapy with FOLFOX versus fluorouracil and cisplatin in patients with oesophageal cancer (PRODIGE5/ACCORD17): final results of a randomised, phase 2/3 trial.
New
Impact
Fédération Francophone de Cancérologie Digestive and UNICANCER-GI Group et al., Vandœuvre-lès-Nancy, France. In Lancet Oncol, Mar 2014
Of all-grade adverse events that occurred in 5% or more of patients, paraesthesia (61 [47%] events in 131 patients in the FOLFOX group vs three [2%] in 128 patients in the cisplatin-fluorouracil group, p<0·0001), sensory neuropathy (24 [18%] vs one [1%], p<0·0001), increases in aspartate aminotransferase concentrations (14 [11%] vs two [2%], p=0·002), and increases in alanine aminotransferase concentrations (11 [8%] vs two [2%], p=0·012) were more common in the FOLFOX group, whereas serum creatinine increases (four [3%] vs 15 [12%], p=0·007), mucositis (35 [27%] vs 41 [32%], p=0·011), and alopecia (two [2%] vs 12 [9%], p=0·005) were more common in the fluorouracil and cisplatin group.
Androgens for the anaemia of chronic kidney disease in adults.
Review
Wu et al., Seoul, South Korea. In Cochrane Database Syst Rev, 2013
The small number of included studies, and low participant numbers adversely influenced evidence quality overall.We found limited evidence (1 study, 24 participants) to indicate that oxymetholone can increase haemoglobin (Hb) (MD 1.90 g/dL, 95% CI 1.66 to 2.14), haematocrit (HCT) (MD 27.10%, 95% CI 26.49 to 27.71), change in albumin (MD 4.91 g/L, 95% CI 3.69 to 6.13), alanine aminotransferase (ALT) (MD 54.50 U/L, 95% CI 43.94 to 65.06), and aspartate aminotransferase (AST) (MD 47.33 U/L, 95% CI 37.69 to 56.97); and decrease high-density lipoprotein (HDL) (MD -15.66 mg/dL, 95% CI -24.84 to -6.48).
Methotrexate for induction of remission in ulcerative colitis.
Review
McDonald et al., London, Canada. In Cochrane Database Syst Rev, 2013
Adverse events experienced by methotrexate patients in the active comparator study included nausea and dyspepsia, mild alopecia, mild increase in aspartate aminotransferase levels, peritoneal abscess, hypoalbuminemia, severe rash and atypical pneumonia.
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
GeneRIF
Hamilton et al., Boston, United States. In Biophys J, 2012
The lipid binding process in L-FABP is associated with backbone dynamics.
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
GeneRIF
Li et al., Blacksburg, United States. In Biosci Rep, 2011
The role of mAspAT in vivo is to control the levels of endogenous kynurenic acid (KYNA) through modulation of the mAspAt in the mouse brain.
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
GeneRIF
Du et al., Beijing, China. In Lab Invest, 2011
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
GeneRIF
Li et al., Blacksburg, United States. In Bmc Biochem, 2009
KAT IV inhibited by equimolar tryptophan and aspartate, and half-life is 6.5 minutes at 65 degree C.
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle.
GeneRIF
Winnicka et al., Białystok, Poland. In J Physiol Pharmacol, 2008
FAT/CD36 and FABPpm protein content was increased in red muscles in IL-6(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG).
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