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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Jul 2015.

Glutamic-oxaloacetic transaminase 2, mitochondrial

aspartate aminotransferase, FABPpm, mAAT
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, ACID, CAN, AGE, Serum albumin
Papers using aspartate aminotransferase antibodies
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
Supplier
Yang J et al., In Cancer Gene Therapy, 2003
... The mouse alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme-linked immunosorbent assay (ELISA) kits were purchased from Uscn Life Science (Wuhan, China) ...
Papers on aspartate aminotransferase
Demethylation of tumor necrosis factor-α converting enzyme promoter associated with high hepatitis B e antigen level in chronic hepatitis B.
New
Wang et al., Jinan, China. In World J Gastroenterol, 21 Aug 2015
P < 0.01) and aspartate aminotransferase (r = -0.329,
Inhibition of lipogenesis reduces inflammation and organ injury in sepsis.
New
Wang et al., New York City, United States. In J Surg Res, 02 Aug 2015
Administration of C75 dose dependently reduced serum indexes of organ injury (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase) and serum levels of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6).
Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial.
New
Impact
REACH Trial Investigators et al., Boston, United States. In Lancet Oncol, 31 Jul 2015
Grade 3 or greater adverse events occurring in 5% or more of patients in either treatment group were ascites (13 [5%] of 277 patients treated with ramucirumab vs 11 [4%] of 276 patients treated with placebo), hypertension (34 [12%] vs ten [4%]), asthenia (14 [5%] vs five [2%]), malignant neoplasm progression (18 [6%] vs 11 [4%]), increased aspartate aminotransferase concentration (15 [5%] vs 23 [8%]), thrombocytopenia (13 [5%] vs one [<1%]), hyperbilirubinaemia (three [1%] vs 13 [5%]), and increased blood bilirubin (five [2%] vs 14 [5%]).
Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
Review
New
Xiao et al., Chengdu, China. In J Ethnopharmacol, 20 Jul 2015
The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL).
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, 30 Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
Gardenia jasminoides extracts and gallic acid inhibit lipopolysaccharide-induced inflammation by suppression of JNK2/1 signaling pathways in BV-2 cells.
New
Hou et al., T'ai-chung-shih, Taiwan. In Iran J Basic Med Sci, 30 Jun 2015
The GJ extract and GA significantly decreased serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in LPS-treated rats.
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.
New
Impact
MITO 11 investigators et al., Napoli, Italy. In Lancet Oncol, May 2015
The most common grade 3-4 adverse events were neutropenia (11 [30%] in the pazopanib group vs one [3%] in the paclitaxel group), fatigue (four [11%] vs two [6%]), leucopenia (four [11%] vs one [3%]), hypertension (three [8%] vs none [0%]), raised aspartate aminotransferase or alanine aminotransferase (three [8%] vs none), and anaemia (two [5%] vs five [14%]).
A critical review of pharmacological significance of Hydrogen Sulfide in hypertension.
Review
New
Johns et al., George Town, Malaysia. In Indian J Pharmacol, May 2015
Recently, the third enzyme, 3-mercaptopyruvate sulfur transferase, along with cysteine aminotransferase, which is similar to aspartate aminotransferase, has been found to produce H2S in the brain.
Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): a randomised phase 2 trial.
New
Impact
Penel et al., Villejuif, France. In Lancet Oncol, Mar 2015
The most common grade 3 and 4 toxicities were alanine aminotransferase or aspartate aminotransferase increases (one [4%] in the interruption group vs three [14%] in the continuation group), neutropenia (two [8%] vs two [10%]), and intestinal occlusion (one [4%] vs one [5%]).
Antioxidative Role of Hatikana (Leea macrophylla Roxb.) Partially Improves the Hepatic Damage Induced by CCl4 in Wistar Albino Rats.
New
Hasan Chowdhury et al., Chittagong, Bangladesh. In Biomed Res Int, Dec 2014
Carbon tetrachloride induction increased the level of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and other biochemical parameters such as lipid profiles, total protein, and CK-MB.
Salivary and serum biomarkers for the study of side effects of aripiprazole coprescribed with mirtazapine in rats.
New
Camen et al., Craiova, Romania. In Int J Clin Exp Med, Dec 2014
Tumor necrosis factor alpha (TNF-α), liver fatty acid binding protein (L-FABP/FABP1) and repulsive guidance molecule C/hemojuvelin (RGM-C/HJV) levels were determined in serum and in saliva.
Clinical illness and outcomes in patients with Ebola in Sierra Leone.
New
Impact
WHO Clinical Response Team et al., Aş Şanamayn, Syria. In N Engl J Med, Dec 2014
Clinical and laboratory factors at presentation that were associated with a fatal outcome included fever, weakness, dizziness, diarrhea, and elevated levels of blood urea nitrogen, aspartate aminotransferase, and creatinine.
Diagnosis of alcoholic liver disease.
Review
New
Medici et al., Sacramento, United States. In World J Gastroenterol, Oct 2014
Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean corpuscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio.
Effects of lixisenatide on elevated liver transaminases: systematic review with individual patient data meta-analysis of randomised controlled trials on patients with type 2 diabetes.
Review
Vilsbøll et al., Hvidovre, Denmark. In Bmj Open, 2013
MAIN OUTCOME MEASURES: Normalisation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
Androgens for the anaemia of chronic kidney disease in adults.
Review
Wu et al., Seoul, South Korea. In Cochrane Database Syst Rev, 2013
The small number of included studies, and low participant numbers adversely influenced evidence quality overall.We found limited evidence (1 study, 24 participants) to indicate that oxymetholone can increase haemoglobin (Hb) (MD 1.90 g/dL, 95% CI 1.66 to 2.14), haematocrit (HCT) (MD 27.10%, 95% CI 26.49 to 27.71), change in albumin (MD 4.91 g/L, 95% CI 3.69 to 6.13), alanine aminotransferase (ALT) (MD 54.50 U/L, 95% CI 43.94 to 65.06), and aspartate aminotransferase (AST) (MD 47.33 U/L, 95% CI 37.69 to 56.97); and decrease high-density lipoprotein (HDL) (MD -15.66 mg/dL, 95% CI -24.84 to -6.48).
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
GeneRIF
Hamilton et al., Boston, United States. In Biophys J, 2012
The lipid binding process in L-FABP is associated with backbone dynamics.
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
GeneRIF
Li et al., Blacksburg, United States. In Biosci Rep, 2011
The role of mAspAT in vivo is to control the levels of endogenous kynurenic acid (KYNA) through modulation of the mAspAt in the mouse brain.
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
GeneRIF
Du et al., Beijing, China. In Lab Invest, 2011
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
GeneRIF
Li et al., Blacksburg, United States. In Bmc Biochem, 2009
KAT IV inhibited by equimolar tryptophan and aspartate, and half-life is 6.5 minutes at 65 degree C.
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle.
GeneRIF
Winnicka et al., Białystok, Poland. In J Physiol Pharmacol, 2008
FAT/CD36 and FABPpm protein content was increased in red muscles in IL-6(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG).
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