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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Sep 2015.

Glutamic-oxaloacetic transaminase 2, mitochondrial

aspartate aminotransferase, FABPpm, mAAT
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, AGE, ACID, CAN, Serum albumin
Papers using aspartate aminotransferase antibodies
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
Supplier
Yang J et al., In Cancer Gene Therapy, 2003
... The mouse alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme-linked immunosorbent assay (ELISA) kits were purchased from Uscn Life Science (Wuhan, China) ...
Papers on aspartate aminotransferase
A Pilot Study of the Telomerase Inhibitor Imetelstat for Myelofibrosis.
New
Impact
Pardanani et al., Rochester, United States. In N Engl J Med, 03 Oct 2015
Treatment-related adverse events included grade 4 thrombocytopenia (in 18% of patients), grade 4 neutropenia (in 12%), grade 3 anemia (in 30%), and grade 1 or 2 elevation in levels of total bilirubin (in 12%), alkaline phosphatase (in 21%), and aspartate aminotransferase (in 27%).
Exendin-4 attenuates brain death-induced liver damage in the rat.
New
Crispim et al., Porto Alegre, Brazil. In Liver Transpl, 03 Oct 2015
Here, we show that Exendin-4 administration to the brain-dead liver donors significantly reduces levels of circulating aspartate aminotransferase (AST) and lactate dehydrogenase (LDH).
Association of aspartate aminotransferase with mortality in hemodialysis patients.
New
Moradi et al., Orange, United States. In Nephrol Dial Transplant, 01 Oct 2015
The relationship between aspartate aminotransferase (AST) and survival has not yet been addressed in these patients.
Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats.
New
Xu et al., Guangzhou, China. In Toxicol Appl Pharmacol, 01 Oct 2015
Taurine zinc significantly attenuated the reductions in blood pressure, left ventricular pressure and ±dp/dtmax, increases in serum alanine aminotransferase and aspartate aminotransferase activities, and reductions in serum Zn(2+) and albumin levels (P<0.05 or 0.01) induced by doxorubicin.
Predictive score for early diagnosis of acute encephalopathy with biphasic seizures and late reduced diffusion (AESD).
New
Mizuguchi et al., Narashino, Japan. In J Neurol Sci, 12 Sep 2015
We proposed an AESD prediction score system consisting of consciousness level, age, duration of convulsions, enforcement of mechanical intubation, and aspartate aminotransferase, blood glucose and creatinine levels (full score: 9), the mean scores in AESD and PFS being 5.9 and 1.8, which were significantly different (p<0.001).
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.
New
Impact
Sabatini et al., Cambridge, United States. In Cell, 30 Aug 2015
The screen yielded GOT1, the cytosolic aspartate aminotransferase, loss of which kills cells upon ETC inhibition.
Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib (REACH): a randomised, double-blind, multicentre, phase 3 trial.
New
Impact
REACH Trial Investigators et al., Boston, United States. In Lancet Oncol, Jul 2015
Grade 3 or greater adverse events occurring in 5% or more of patients in either treatment group were ascites (13 [5%] of 277 patients treated with ramucirumab vs 11 [4%] of 276 patients treated with placebo), hypertension (34 [12%] vs ten [4%]), asthenia (14 [5%] vs five [2%]), malignant neoplasm progression (18 [6%] vs 11 [4%]), increased aspartate aminotransferase concentration (15 [5%] vs 23 [8%]), thrombocytopenia (13 [5%] vs one [<1%]), hyperbilirubinaemia (three [1%] vs 13 [5%]), and increased blood bilirubin (five [2%] vs 14 [5%]).
Yinchenhao decoction in the treatment of cholestasis: A systematic review and meta-analysis.
Review
New
Xiao et al., Chengdu, China. In J Ethnopharmacol, Jul 2015
The RCTs examined included total efficacy rate and biochemical indices including alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL) and direct bilirubin (DBIL).
Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial.
New
Impact
CONCUR Investigators et al., Shanghai, China. In Lancet Oncol, Jun 2015
The most frequent grade 3 or higher regorafenib-related adverse events were hand-foot skin reaction (22 [16%] of 136 patients in the regorafenib group vs none in the placebo group), hypertension (15 [11%] vs two [3%] of 68 patients in the placebo group), hyperbilirubinaemia (nine [7%] vs one [1%]), hypophosphataemia (nine [7%] vs none), alanine aminotransferase concentration increases (nine [7%] vs none), aspartate aminotransferase concentration increases (eight [6%] vs none), lipase concentration increases (six [4%] vs one [1%]), and maculopapular rash (six [4%] vs none).
A critical review of pharmacological significance of Hydrogen Sulfide in hypertension.
Review
New
Johns et al., George Town, Malaysia. In Indian J Pharmacol, May 2015
Recently, the third enzyme, 3-mercaptopyruvate sulfur transferase, along with cysteine aminotransferase, which is similar to aspartate aminotransferase, has been found to produce H2S in the brain.
Pazopanib plus weekly paclitaxel versus weekly paclitaxel alone for platinum-resistant or platinum-refractory advanced ovarian cancer (MITO 11): a randomised, open-label, phase 2 trial.
New
Impact
MITO 11 investigators et al., Napoli, Italy. In Lancet Oncol, May 2015
The most common grade 3-4 adverse events were neutropenia (11 [30%] in the pazopanib group vs one [3%] in the paclitaxel group), fatigue (four [11%] vs two [6%]), leucopenia (four [11%] vs one [3%]), hypertension (three [8%] vs none [0%]), raised aspartate aminotransferase or alanine aminotransferase (three [8%] vs none), and anaemia (two [5%] vs five [14%]).
The Relationship between Cardiotrophin-1 and Troponin-I in Coronary Arterial Bypass Grafting on the Beating Heart: A Prospective Study.
New
Bicer et al., Bursa, Turkey. In Heart Surg Forum, Dec 2014
There was also an elevation in white blood cells, aspartate aminotransferase, creatine kinase (CK), and creatine kinase MB (CK-MB) values, as well as a decrease in hemoglobin values (P < .001).
Diagnosis of alcoholic liver disease.
Review
New
Medici et al., Sacramento, United States. In World J Gastroenterol, Oct 2014
Typical laboratory findings in ALD include transaminase levels with aspartate aminotransferase greater than alanine aminotransferase as well as increased mean corpuscular volume, gamma-glutamyltranspeptidase, and IgA to IgG ratio.
Effects of lixisenatide on elevated liver transaminases: systematic review with individual patient data meta-analysis of randomised controlled trials on patients with type 2 diabetes.
Review
Vilsbøll et al., Hvidovre, Denmark. In Bmj Open, 2013
MAIN OUTCOME MEASURES: Normalisation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST).
Androgens for the anaemia of chronic kidney disease in adults.
Review
Wu et al., Seoul, South Korea. In Cochrane Database Syst Rev, 2013
The small number of included studies, and low participant numbers adversely influenced evidence quality overall.We found limited evidence (1 study, 24 participants) to indicate that oxymetholone can increase haemoglobin (Hb) (MD 1.90 g/dL, 95% CI 1.66 to 2.14), haematocrit (HCT) (MD 27.10%, 95% CI 26.49 to 27.71), change in albumin (MD 4.91 g/L, 95% CI 3.69 to 6.13), alanine aminotransferase (ALT) (MD 54.50 U/L, 95% CI 43.94 to 65.06), and aspartate aminotransferase (AST) (MD 47.33 U/L, 95% CI 37.69 to 56.97); and decrease high-density lipoprotein (HDL) (MD -15.66 mg/dL, 95% CI -24.84 to -6.48).
Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.
GeneRIF
Hamilton et al., Boston, United States. In Biophys J, 2012
The lipid binding process in L-FABP is associated with backbone dynamics.
Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
GeneRIF
Li et al., Blacksburg, United States. In Biosci Rep, 2011
The role of mAspAT in vivo is to control the levels of endogenous kynurenic acid (KYNA) through modulation of the mAspAt in the mouse brain.
Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats.
GeneRIF
Du et al., Beijing, China. In Lab Invest, 2011
Results suggest that downregulation of the endogenous SO(2)/GOT pathway is likely involved in the pathogenesis of ISO-induced myocardial injury.
Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.
GeneRIF
Li et al., Blacksburg, United States. In Bmc Biochem, 2009
KAT IV inhibited by equimolar tryptophan and aspartate, and half-life is 6.5 minutes at 65 degree C.
IL-6 deficiency increases fatty acid transporters and intramuscular lipid content in red but not white skeletal muscle.
GeneRIF
Winnicka et al., Białystok, Poland. In J Physiol Pharmacol, 2008
FAT/CD36 and FABPpm protein content was increased in red muscles in IL-6(-/-) mice compared to WT mice at 4 (RG) and 12 months (soleus and RG).
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