Asparagine Metabolic Pathways in Arabidopsis.
Versailles, France. In Plant Cell Physiol, Jan 2016
UNASSIGNED: Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.
Transgenic poplar expressing the pine GS1a show alterations in nitrogen homeostasis during drought.
Newark, United States. In Plant Physiol Biochem, Sep 2015
Transcript levels of nitrogen-related genes in leaves, including GS/GOGAT cycle enzymes, aspartate aminotransferase, GABA shunt enzymes, photorespiration enzymes, asparagine synthetase, phenylalanine ammonia lyase, isocitrate dehydrogenase, and PII, were also assessed using qPCR revealing significant differences between GS poplars and the WT.
Asparaginases: biochemical pharmacology and modes of drug resistance.
Los Angeles, United States. In Anticancer Res, 2012
The emphasis will turn to ASNase, their mechanisms of action, the immune responses they cause in a significant percentage of the ALL patients, the significance of the up-regulation of glutamine synthetase and asparagine synthetase and the complexity of the elucidation of the mechanisms of action of ASNase.
Asparagine synthetase chemotherapy.
Gainesville, United States. In Annu Rev Biochem, 2005
Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up-regulation of the enzyme glutamine-dependent asparagine synthetase (ASNS).
Enzymes with molecular tunnels.
College Station, United States. In Acc Chem Res, 2003
Since the first molecular tunnel within tryptophan synthase was discovered in 1988, tunnels within carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, asparagine synthetase, glutamate synthase, imidazole glycerol phosphate synthase, glucosamine 6-phosphate synthase, and carbon monoxide dehydrogenase/acetyl-CoA synthase have been identified.
Channeling of substrates and intermediates in enzyme-catalyzed reactions.
Pearl River, United States. In Annu Rev Biochem, 2000
The three-dimensional structures of tryptophan synthase, carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, and asparagine synthetase have revealed the relative locations of multiple active sites within these proteins.