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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Asparagine synthetase

asparagine synthetase
Top mentioned proteins: ACID, Asparaginase, CAN, HAD, V1a
Papers on asparagine synthetase
Asparagine Metabolic Pathways in Arabidopsis.
New
Suzuki et al., Versailles, France. In Plant Cell Physiol, Jan 2016
UNASSIGNED: Inorganic nitrogen in the form of ammonium is assimilated into asparagine via multiple steps involving glutamine synthetase (GS), glutamate synthase (GOGAT), aspartate aminotransferase (AspAT) and asparagine synthetase (AS) in Arabidopsis.
Asparaginase Therapy in Pediatric Acute Lymphoblastic Leukemia: A Focus on the Mode of Drug Resistance.
Review
New
Chen, Taiwan. In Pediatr Neonatol, Oct 2015
It was suggested early on that leukemic cells are resistant to asparaginase because of their increased asparagine synthetase activity.
Asparagine Synthetase Expression and Phase I Study With L-Asparaginase Encapsulated in Red Blood Cells in Patients With Pancreatic Adenocarcinoma.
New
André et al., Lyon, France. In Pancreas, Oct 2015
OBJECTIVES: Asparaginase encapsulated in erythrocytes (ERY-ASP) is a potentially effective drug in patients with pancreatic adenocarcinoma (PAC) with null/low asparagine synthetase (ASNS) expression.
Transgenic poplar expressing the pine GS1a show alterations in nitrogen homeostasis during drought.
New
Kirby et al., Newark, United States. In Plant Physiol Biochem, Sep 2015
Transcript levels of nitrogen-related genes in leaves, including GS/GOGAT cycle enzymes, aspartate aminotransferase, GABA shunt enzymes, photorespiration enzymes, asparagine synthetase, phenylalanine ammonia lyase, isocitrate dehydrogenase, and PII, were also assessed using qPCR revealing significant differences between GS poplars and the WT.
L-Asparaginase monotherapy for EBV-positive T/NK lymphoproliferative diseases: A pilot Study.
Arai et al., Tokyo, Japan. In J Med Dent Sci, 2014
The mRNA levels of asparagine synthetase in EBV-infected cells were examined.
Asparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections.
Padmanaban et al., Bengaluru, India. In Nat Commun, 2014
Plasmodium depends primarily on host haemoglobin degradation for amino acids and has a rudimentary pathway for amino acid biosynthesis, but retains a gene encoding asparagine synthetase (AS).
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.
Wagers et al., Cambridge, United States. In Elife, 2014
Silencing of asparagine synthetase (ASNS), an amidotransferase that converts aspartate into asparagine, produced the strongest inhibitory effect on sarcoma growth in a functional genomic screen of mouse sarcomas generated by oncogenic Kras and disruption of Cdkn2a.
Induction of endoplasmic reticulum stress and unfolded protein response constitutes a pathogenic strategy of group A streptococcus.
Review
Hanski et al., Jerusalem, Israel. In Front Cell Infect Microbiol, 2013
By poorly understood pathways, these toxins trigger UPR leading to the induction of the transcriptional regulator ATF4 and consequently to the upregulation of asparagine synthetase (ASNS) transcription leading to production and release of ASN.
Asparagine: an amide of particular distinction in the regulation of symbiotic nitrogen fixation of legumes.
Review
Tran et al., Khartoum, Sudan. In Crit Rev Biotechnol, 2013
Current research revealed unique advances for nodule metabolism, especially on the regulation of asparagine synthetase gene expression and the control of asparagine (ASN) to N2 fixing activity.
Red blood cell-encapsulated L-asparaginase: potential therapy of patients with asparagine synthetase deficient acute myeloid leukemia.
Review
Frankel et al., Temple, United States. In Protein Pept Lett, 2013
Red blood cell (RBC) encapsulated L-asparaginase is a novel therapeutic for the treatment of asparagine auxotrophic malignancies.
Asparaginases: biochemical pharmacology and modes of drug resistance.
Review
Avramis, Los Angeles, United States. In Anticancer Res, 2012
The emphasis will turn to ASNase, their mechanisms of action, the immune responses they cause in a significant percentage of the ALL patients, the significance of the up-regulation of glutamine synthetase and asparagine synthetase and the complexity of the elucidation of the mechanisms of action of ASNase.
Asparagine synthetase chemotherapy.
Review
Impact
Kilberg et al., Gainesville, United States. In Annu Rev Biochem, 2005
Significant side effects can arise in these protocols and, in many cases, patients develop drug-resistant forms of the disease that may be correlated with up-regulation of the enzyme glutamine-dependent asparagine synthetase (ASNS).
Enzymes with molecular tunnels.
Review
Impact
Holden et al., College Station, United States. In Acc Chem Res, 2003
Since the first molecular tunnel within tryptophan synthase was discovered in 1988, tunnels within carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, asparagine synthetase, glutamate synthase, imidazole glycerol phosphate synthase, glucosamine 6-phosphate synthase, and carbon monoxide dehydrogenase/acetyl-CoA synthase have been identified.
Channeling of substrates and intermediates in enzyme-catalyzed reactions.
Review
Impact
Raushel et al., Pearl River, United States. In Annu Rev Biochem, 2000
The three-dimensional structures of tryptophan synthase, carbamoyl phosphate synthetase, glutamine phosphoribosylpyrophosphate amidotransferase, and asparagine synthetase have revealed the relative locations of multiple active sites within these proteins.
Asparagine synthetase activity of mouse leukemias.
Impact
Stockert et al., In Science, 1968
Various transplanted leukemias and normal tissues of the mouse were tested for asparagine synthetase activity.
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