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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Asparaginase homolog

Asparaginase, L-asparaginase, aspartyl protease
displays lysophospholipase, asparaginase and platelet-activating factor acetylhydrolase activities [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, AGE, Glutaminase
Papers on Asparaginase
Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages.
New
Stone et al., In Biochemistry, Feb 2016
UNASSIGNED: The human asparaginase-like protein 1 (hASRGL1) is a member of the N-terminal nucleophile (Ntn) family that hydrolyzes L-asparagine and isoaspartyl-dipeptides.
Asparaginase Erwinia chrysanthemi as a component of a multi-agent chemotherapeutic regimen for the treatment of patients with acute lymphoblastic leukemia who have developed hypersensitivity to E. coli-derived asparaginase.
New
Drachtman et al., New Brunswick, United States. In Expert Rev Hematol, Feb 2016
UNASSIGNED: Asparaginase has been a mainstay of therapy in the treatment of acute lymphoblastic leukemia since the 1970s.
Role of Candida albicans secreted aspartyl protease Sap9 in interkingdom biofilm formation.
New
Nobbs et al., Louisville, United States. In Pathog Dis, Feb 2016
UNASSIGNED: The fungus Candida albicans colonizes oral cavity surfaces and is carried by up to 60% of human populations.
L-asparaginase as a critical component to combat Acute Lymphoblastic Leukaemia (ALL): A novel approach to target ALL.
Review
New
Mumtaz et al., Wuhan, China. In Eur J Pharmacol, Jan 2016
UNASSIGNED: L-asparaginase, an anti-leukaemic drug that has been approved for clinical use for many years in the treatment of childhood Acute Lymphoblastic Leukaemia (ALL), is obtained from bacterial origin (Escherichia coli and Erwinia carotovora).
Chronic T-cell Lymphocytic Leukemia in a Black Swan ( Cygnus atratus ): Diagnosis, Treatment, and Pathology.
New
BVSc et al., In J Avian Med Surg, Dec 2015
The bird showed partial response to treatment with chlorambucil, lomustine, prednisone, l-asparaginase, and whole-body radiation, with neither evidence of adverse effects nor clinical signs of disease.
Intravenous pegylated asparaginase versus intramuscular native Escherichia colil-asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial.
New
Impact
Silverman et al., Boston, United States. In Lancet Oncol, Dec 2015
BACKGROUND: l-asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered intramuscularly.
Anti-Alzheimer Therapeutic Drugs Targeting γ-Secretase.
Review
New
Hua et al., Beijing, China. In Curr Top Med Chem, Dec 2015
γ-secretase is a membrane-embedded aspartyl protease carrying out cleavage of more than 100 single transmembrane-spanning proteins, including APP, Notch, N-cadherin, etc.
Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia.
New
Debatin et al., Ulm, Germany. In Cell Death Dis, Dec 2015
Importantly, BV6 increased the effectivity of conventional induction therapy including vincristine, dexamethasone and asparaginase leading to prolonged remission induction.
A Comprehensive Review on L-Asparaginase and Its Applications.
Review
New
Yusoff et al., Kuantan, Malaysia. In Appl Biochem Biotechnol, Dec 2015
UNASSIGNED: L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate.
Best Practices in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia: A Focus on Asparaginase.
Review
New
Sender et al., Paris, France. In J Adolesc Young Adult Oncol, Oct 2015
The inclusion of asparaginase in chemotherapy regimens to treat acute lymphoblastic leukemia (ALL) has had a positive impact on survival in pediatric patients.
Pharmacokinetic and pharmacodynamic properties of calaspargase pegol Escherichia coli L-asparaginase in the treatment of patients with acute lymphoblastic leukemia: results from Children's Oncology Group Study AALL07P4.
Impact
Hunger et al., Gaithersburg, United States. In J Clin Oncol, 2015
Pegaspargase (SS-PEG), a pegylated form of Escherichia coli L-asparaginase with a succinimidyl succinate (SS) linker, is the first-line asparaginase product used in Children's Oncology Group (COG) ALL trials.
L-asparaginase and venous thromboembolism in acute lymphocytic leukemia.
Review
Bhatt et al., Omaha, United States. In Future Oncol, 2014
The occurrence of venous thromboembolism (VTE) in acute lymphocytic leukemia patients receiving L-asparaginase therapy may cause significant morbidity, neurological sequela and possibly worse outcomes.
Augmented post-remission therapy for a minimal residual disease-defined high-risk subgroup of children and young people with clinical standard-risk and intermediate-risk acute lymphoblastic leukaemia (UKALL 2003): a randomised controlled trial.
Impact
Wade et al., Oxford, United Kingdom. In Lancet Oncol, 2014
Compared with standard therapy, the augmented treatment regimen (regimen C) included an additional eight doses of pegylated asparaginase, 18 doses of vincristine, and escalated-dose intravenous methotrexate without folinic acid rescue during interim maintenance courses.
Pharmacokinetics-based integration of multiple doses of intravenous pegaspargase in a pediatric regimen for adults with newly diagnosed acute lymphoblastic leukemia.
Impact
Mohrbacher et al., Los Angeles, United States. In J Clin Oncol, 2014
PURPOSE: Asparaginase treatment is standard in all pediatric acute lymphoblastic leukemia (ALL) regimens, whereas in adults, it is either excluded or administered for a shorter duration.
Treatment reduction for children and young adults with low-risk acute lymphoblastic leukaemia defined by minimal residual disease (UKALL 2003): a randomised controlled trial.
Impact
Richards et al., Sheffield, United Kingdom. In Lancet Oncol, 2013
Delayed intensification consisted of pegylated asparaginase on day 4; vincristine, dexamethasone (alternate weeks), and doxorubicin for 3 weeks; and 4 weeks of cyclophosphamide and cytarabine.
Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis.
GeneRIF
Freedman et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
NUDT11, HNF1B, and SLC22A3 genes have roles in prostate cancer pathogenesis
Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.
GeneRIF
Stoffel et al., Zürich, Switzerland. In Biol Chem, 2012
Tmem27 dimerization is a dynamic process involving Bace2
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.
Impact
GeneRIF
Stoffel et al., Zürich, Switzerland. In Cell Metab, 2011
Bace2 is a beta cell-enriched protease that regulates pancreatic beta cell function and mass.
β-Secretase activity in rat astrocytes: translational block of BACE1 and modulation of BACE2 expression.
GeneRIF
Zacchetti et al., Milano, Italy. In Eur J Neurosci, 2011
Data show that astrocytes possess beta-secretase activity and produce amyloid-beta because of the activity of BACE2, but not BACE1, the expression of which is blocked at the translational level.
60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC.
GeneRIF
Perrotti et al., Catanzaro, Italy. In Cell Physiol Biochem, 2009
The 60kDa lysophospholipase downregulates basal and Sgk1-dependent ENaC activity.
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