Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid.
Seoul, South Korea. In Biochem Biophys Res Commun, 19 Sep 2015
In this study, we investigated the relationship between reduced levels of brain-derived neurotrophic factor (BDNF) in lesioned brain regions and caspase activity, as well as involvement of apoptosis signal-regulating kinase 1 (ASK1) in caspase activation.We analyzed apoptotic cell death, BDNF distribution, caspase-3 activity, caspase-6 activity, ASK1 expression level, and active ASK1 in the cortex and striatum.
A Novel Monoclonal Antibody Against Human DAB2IP.
Chengdu, China. In Monoclon Antib Immunodiagn Immunother, 31 Aug 2015
DAB2 interactive protein (DAB2IP), also known as ASK1-interacting protein-1 (AIP1), a novel member of the RasGTPase-activating protein family, plays a key role in tumor suppression during cancer progression and is highly expressed in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs).