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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Oct 2014.

Mitogen-activated protein kinase kinase kinase 5

ASK1, apoptosis signal-regulating kinase 1, Dbf4
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, p38, AP-1, V1a, MAPK
Papers using ASK1 antibodies
Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling
Supplier
Choi Yongwon et al., In The Journal of Experimental Medicine, 1998
... ), JNK1 (N-19), MEKK1 (C-22), and ASK1 (H-300) were from Santa Cruz Biotechnology, Inc.; β-actin (Ab-1) was ...
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities
Supplier
Choi Eui-Ju et al., In The Journal of Cell Biology, 1994
... Rabbit anti-ASK1 and anti-hexahistidine (His) pAbs were purchased from Santa Cruz Biotechnology.
Papers on ASK1
Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells.
New
Ren et al., Changsha, China. In Exp Ther Med, 30 Nov 2014
The results revealed that casticin significantly induced apoptosis of HT-29, HCT-116, SW480 and Caco-2 cells, induced the accumulation of reactive oxygen species (ROS) and increased the protein levels of apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK) and B-cell lymphoma 2-interacting mediator of cell death (Bim) in HT-29 cells.
Apoptotic events induced by high glucose in human hepatoma HepG2 cells involve endoplasmic reticulum stress and MAPK's activation.
New
Wang et al., Hefei, China. In Mol Cell Biochem, 09 Nov 2014
In addition, western blot analysis presented that phosphorylation of p38 and JNK was triggered and that the expression of ASK1 was elevated.
ASK1/p38 signalling in renal tubular epithelial cells promotes renal fibrosis in the mouse obstructed kidney.
New
Nikolic-Paterson et al., France. In Am J Physiol Renal Physiol, 08 Nov 2014
Apoptosis signal-regulating kinase 1 (ASK1/MAP3K5) is a member of the MAPKKK family which can induce activation of p38 and JNK.
[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].
Review
New
Ichijo et al., In Nihon Rinsho, May 2014
Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase belonging to the mitogen-activated protein kinase (MAPK) kinase kinase family.
Heat shock proteins in the brain: role of Hsp70, Hsp 27, and HO-1 (Hsp32) and their therapeutic potential.
Review
New
Liu et al., Sacramento, United States. In Transl Stroke Res, Dec 2013
In the brain, protein kinase D phosphorylates Hsp27 following ischemia which then binds apoptosis signal-regulating kinase 1 to prevent MKK4/7, c-Jun NH(2)-terminal kinase, and Jun-induced apoptosis, and decrease infarct volumes following focal cerebral ischemia.
Targeting Apoptosis Signalling Kinase-1 (ASK-1) Does Not Prevent the Development of Neuropathy in Streptozotocin-Induced Diabetic Mice.
New
Gardiner et al., Manchester, United Kingdom. In Plos One, Dec 2013
Apoptosis signal-regulating kinase-1 (ASK1) is a mitogen-activated protein 3 kinase (MAPKKK/MAP3K) which lies upstream of the stress-activated MAPKs, JNK and p38.
TRAF1 is a key mediator for hepatic ischemia/reperfusion injury.
New
Li et al., Wuhan, China. In Cell Death Dis, Dec 2013
Mechanistic studies demonstrated that a deficiency of TRAF1 in cultured hepatocytes led to the inhibition of NF-κB-mediated inflammatory responses, suppression of the ASK/JNK pro-death pathway and promotion of cellular regeneration capacity.
Cadmium and cellular signaling cascades: interactions between cell death and survival pathways.
Review
New
Lee et al., Witten, Germany. In Arch Toxicol, Oct 2013
Severe ROS/Ca(2+) signals activate cell death effectors (ceramides, ASK1-JNK/p38, calpains, caspases) and/or cause irreversible damage to vital organelles, such as mitochondria and endoplasmic reticulum (ER), whereas low localized ROS/Ca(2+) levels act as 2nd messengers promoting cellular adaptation and survival through signal transduction (ERK1/2, PI3K/Akt-PKB) and transcriptional regulators (Ref1-Nrf2, NF-κB, Wnt, AP-1, bestrophin-3).
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis.
Review
New
Sil et al., Calcutta, India. In Arch Toxicol, Jul 2013
Emphasis has been given on the redox-sensitive ASK1 signalosome and its downstream JNK pathway.
ASK1 promotes apoptosis of normal and malignant plasma cells.
GeneRIF
Lin et al., Taipei, Taiwan. In Blood, 2012
A novel mechanism underlying the regulation of survival in normal and malignant plasma cells by ASK1.
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation.
GeneRIF
Zhao et al., Shanghai, China. In Febs Lett, 2012
MCRS2 plays a negative role in stress-induced ASK1 activation.
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.
GeneRIF
Kobayashi et al., Japan. In J Biol Chem, 2012
S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5
TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
GeneRIF
Kang et al., Suwŏn, South Korea. In J Biol Chem, 2012
ASK1 and TAK1 function as MAP3 kinases in Cdo-mediated p38MAPK activation to promote myogenic differentiation.
Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes.
Review
Kim et al., Vancouver, Canada. In J Diabetes Investig, 2012
Recent studies have shown that inhibition of the kinase apoptosis signal-regulating kinase 1 (ASK1) by GIP plays a key role in reducing mitochondria-induced apoptosis in β-cells through protein kinase B (PKB)-mediated pathways, and that GIP-induced post-translational modification of voltage- dependent K(+) (Kv) channels also contributes to its prosurvival role.
A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway.
GeneRIF
Xu et al., Nanjing, China. In Plos One, 2011
Results indicate that the anti-inflammatory properties of DCO-6 was through inhibition of reactive oxygen species-dependent activation of TRAF6-ASK1-p38 pathway.
Damage-induced phosphorylation of Sld3 is important to block late origin firing.
Impact
Toczyski et al., San Francisco, United States. In Nature, 2010
Here we show that the replication initiation protein Sld3 is phosphorylated by Rad53, and that this phosphorylation, along with phosphorylation of the Cdc7 kinase regulatory subunit Dbf4, blocks late origin firing in Saccharomyces cerevisiae.
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Impact
Basu et al., Calcutta, India. In Nat Immunol, 2009
TNF activated a pathway involving the kinases ASK1, p38 and c-Abl.
Apoptosis signal-regulating kinase 1 in stress and immune response.
Review
Impact
GeneRIF
Ichijo et al., Tokyo, Japan. In Annu Rev Pharmacol Toxicol, 2007
discusses the molecular mechanisms by which ASK1 functions in stress and immune responses and discuss the possible involvement of ASK1 in human diseases [review]
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Impact
Zheng et al., Seattle, United States. In Nature, 2007
Here we present the crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide.
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Impact
GeneRIF
Ichijo et al., Tokyo, Japan. In Nat Immunol, 2005
complex of the adaptor molecule TRAF6 and ASK1 and subsequent activation of the ASK1-p38 pathway
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