gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 Aug 2015.

Mitogen-activated protein kinase kinase kinase 5

ASK1, apoptosis signal-regulating kinase 1, Dbf4
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, p38, AP-1, V1a, MAPK
Papers using ASK1 antibodies
Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling
Choi Yongwon et al., In The Journal of Experimental Medicine, 1998
... ), JNK1 (N-19), MEKK1 (C-22), and ASK1 (H-300) were from Santa Cruz Biotechnology, Inc.; β-actin (Ab-1) was ...
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities
Choi Eui-Ju et al., In The Journal of Cell Biology, 1994
... Rabbit anti-ASK1 and anti-hexahistidine (His) pAbs were purchased from Santa Cruz Biotechnology.
Papers on ASK1
Sodium tanshinone II a sulfonate ameliorates microcirculatory disturbance of small intestine by attenuating the production of reactie oxygen species in rats with sepsis.
Chen et al., Wuhan, China. In Chin J Integr Med, 26 Sep 2015
The expressions of apoptosis signal-regulating kinase (ASK1), phosphorylated ASK1 (phospho-ASK1), p38 mitogen-activated protein kinases (p38 MAPK), phosphorylated p38 MAPK (phospho-p38 MAPK) and tissue factor (TF) were determined by Western blotting.
Differential caspase activity in the cortex and striatum with chronic infusion of 3-nitropropionic acid.
Kim et al., Seoul, South Korea. In Biochem Biophys Res Commun, 19 Sep 2015
In this study, we investigated the relationship between reduced levels of brain-derived neurotrophic factor (BDNF) in lesioned brain regions and caspase activity, as well as involvement of apoptosis signal-regulating kinase 1 (ASK1) in caspase activation.We analyzed apoptotic cell death, BDNF distribution, caspase-3 activity, caspase-6 activity, ASK1 expression level, and active ASK1 in the cortex and striatum.
A Quantitative framework to evaluate proarrhythmic risk in a first-in-human study to support waiver of a thorough QT study.
Ramanathan et al., Foster City, United States. In Clin Pharmacol Ther, 11 Sep 2015
UNASSIGNED: The effects of GS-4997 (ASK1 inhibitor) on cardiac repolarization were evaluated using a systematic modeling approach in a first-in-human study.
Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells.
Sun et al., Dalian, China. In Environ Toxicol Pharmacol, 07 Sep 2015
Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells.
Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.
Yang et al., Baltimore, United States. In Am J Obstet Gynecol, 31 Aug 2015
Apoptosis signal-regulating kinase 1 (ASK1) activated by oxidative stress stimulates nuclear translocation of FoxO3a, resulting in the overexpression of tumor necrosis factor receptor 1-associated death domain protein, which, in turn, leads to caspase-8 activation and apoptosis.
A Novel Monoclonal Antibody Against Human DAB2IP.
Hu et al., Chengdu, China. In Monoclon Antib Immunodiagn Immunother, 31 Aug 2015
DAB2 interactive protein (DAB2IP), also known as ASK1-interacting protein-1 (AIP1), a novel member of the RasGTPase-activating protein family, plays a key role in tumor suppression during cancer progression and is highly expressed in vascular smooth muscle cells (VSMCs) and endothelial cells (ECs).
Decoding the oxidative stress hypothesis in diabetic embryopathy through proapoptotic kinase signaling.
Gabbay-Benziv et al., Baltimore, United States. In Am J Obstet Gynecol, May 2015
Work in animal models also has revealed that maternal diabetes triggers a series of signaling intermediates: protein kinase C (PKC) isoforms, PKCα, βII and δ; apoptosis signal-regulating kinase 1; c-Jun-N-terminal kinase (JNK)1/2; caspase; and apoptosis.
Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis.
Yang et al., Baltimore, United States. In World J Diabetes, May 2015
Activation of the apoptosis signal-regulating kinase 1 (ASK1)-forkhead transcription factor 3a (FoxO3a)-caspase 8 pathway causes apoptosis in the developing neural tube leading to neural tube defects (NTDs).
[Inhibition of stress-responsive signaling pathway prevents neural cell death following optic nerve injury].
Katome, In Nihon Ganka Gakkai Zasshi, Nov 2014
Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase kinase kinase (MAPKKK) and plays an important role in stress-induced RGC apoptosis.
[ASK1-MAP kinase signaling pathway as a therapeutic target for human diseases].
Ichijo et al., In Nihon Rinsho, May 2014
Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase belonging to the mitogen-activated protein kinase (MAPK) kinase kinase family.
ASK1 promotes apoptosis of normal and malignant plasma cells.
Lin et al., Taipei, Taiwan. In Blood, 2012
A novel mechanism underlying the regulation of survival in normal and malignant plasma cells by ASK1.
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation.
Zhao et al., Shanghai, China. In Febs Lett, 2012
MCRS2 plays a negative role in stress-induced ASK1 activation.
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.
Kobayashi et al., Japan. In J Biol Chem, 2012
S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5
TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
Kang et al., Suwŏn, South Korea. In J Biol Chem, 2012
ASK1 and TAK1 function as MAP3 kinases in Cdo-mediated p38MAPK activation to promote myogenic differentiation.
A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway.
Xu et al., Nanjing, China. In Plos One, 2011
Results indicate that the anti-inflammatory properties of DCO-6 was through inhibition of reactive oxygen species-dependent activation of TRAF6-ASK1-p38 pathway.
Damage-induced phosphorylation of Sld3 is important to block late origin firing.
Toczyski et al., San Francisco, United States. In Nature, 2010
Here we show that the replication initiation protein Sld3 is phosphorylated by Rad53, and that this phosphorylation, along with phosphorylation of the Cdc7 kinase regulatory subunit Dbf4, blocks late origin firing in Saccharomyces cerevisiae.
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Basu et al., Calcutta, India. In Nat Immunol, 2009
TNF activated a pathway involving the kinases ASK1, p38 and c-Abl.
Apoptosis signal-regulating kinase 1 in stress and immune response.
Ichijo et al., Tokyo, Japan. In Annu Rev Pharmacol Toxicol, 2007
discusses the molecular mechanisms by which ASK1 functions in stress and immune responses and discuss the possible involvement of ASK1 in human diseases [review]
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Zheng et al., Seattle, United States. In Nature, 2007
Here we present the crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide.
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Ichijo et al., Tokyo, Japan. In Nat Immunol, 2005
complex of the adaptor molecule TRAF6 and ASK1 and subsequent activation of the ASK1-p38 pathway
share on facebooktweetadd +1mail to friends