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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 21 May 2016.

Mitogen-activated protein kinase kinase kinase 5

ASK1, apoptosis signal-regulating kinase 1, Dbf4
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: JNK, p38, AP-1, V1a, MAPK
Papers using ASK1 antibodies
Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling
Supplier
Choi Yongwon et al., In The Journal of Experimental Medicine, 1998
... ), JNK1 (N-19), MEKK1 (C-22), and ASK1 (H-300) were from Santa Cruz Biotechnology, Inc.; β-actin (Ab-1) was ...
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities
Supplier
Choi Eui-Ju et al., In The Journal of Cell Biology, 1994
... Rabbit anti-ASK1 and anti-hexahistidine (His) pAbs were purchased from Santa Cruz Biotechnology.
Papers on ASK1
4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells.
New
Fu et al., Linyi, China. In Biochem Biophys Res Commun, Feb 2016
Further studies showed that 4SC-202 induced apoptosis signal-regulating kinase 1 (ASK1) activation, causing it translocation to mitochondria and physical association with Cyp-D.
EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells.
New
Liu et al., Guangzhou, China. In Oncotarget, Feb 2016
Furthermore, inhibition of Trx/TrxR system resulted in the dissociation of ASK1 from Trx and the downstream activation of JNK.
Differential regulation of pro- and antiapoptotic proteins in fish adipocytes during hypoxic conditions.
New
Jayachandran et al., Chennai, India. In Fish Physiol Biochem, Feb 2016
Signaling pathway may lead to cell survival or cell death which is fine-tuned by both positive and negative factors, which includes hypoxia-inducible factor-1α (HIF1α), heat-shock protein-70 (HSP70), phospho-c-Jun N-terminal kinase 1/2 (p-JNK1/2) and apoptosis signal-regulating kinase-1 (ASK1).
Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q.
New
Kim et al., Seoul, South Korea. In Sci Rep, Dec 2015
Apoptosis signal-regulating kinase-1 (ASK1), an early signaling element in the cell death pathway, has been hypothesized to participate in the pathology of neurodegenerative diseases.
Preclinical Evaluation of Liposomal C8 Ceramide as a Potent anti-Hepatocellular Carcinoma Agent.
New
Wang et al., China. In Plos One, Dec 2015
At the molecular level, we showed that liposomal C8 activated ASK1 (apoptosis signal-regulating kinase 1)-JNK (Jun N-terminal protein kinase) signaling in HCC cells.
New development of the yolk sac theory in diabetic embryopathy: molecular mechanism and link to structural birth defects.
Review
New
Yang et al., Baltimore, United States. In Am J Obstet Gynecol, Oct 2015
Studies in animal models have uncovered key molecular intermediates of diabetic yolk sac vasculopathy, which include hypoxia-inducible factor-1α, apoptosis signal-regulating kinase 1, and its inhibitor thioredoxin-1, c-Jun-N-terminal kinases, nitric oxide, and nitric oxide synthase.
Advances in revealing the molecular targets downstream of oxidative stress-induced proapoptotic kinase signaling in diabetic embryopathy.
Review
New
Yang et al., Baltimore, United States. In Am J Obstet Gynecol, Aug 2015
Apoptosis signal-regulating kinase 1 (ASK1) activated by oxidative stress stimulates nuclear translocation of FoxO3a, resulting in the overexpression of tumor necrosis factor receptor 1-associated death domain protein, which, in turn, leads to caspase-8 activation and apoptosis.
AIP1-mediated stress signaling in atherosclerosis and arteriosclerosis.
Review
New
Min et al., Guangzhou, China. In Curr Atheroscler Rep, May 2015
While it was initially discovered as an apoptosis signal-regulating kinase 1 (ASK1)-interacting protein, AIP1 broadly suppresses inflammatory responses triggered by cytokines and stresses such as TNF, LPS, VEGF, and endoplasmic reticulum (ER) stress in EC (therefore, AIP1 is an anti-inflammatory protein).
Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis.
Review
New
Yang et al., Baltimore, United States. In World J Diabetes, May 2015
Activation of the apoptosis signal-regulating kinase 1 (ASK1)-forkhead transcription factor 3a (FoxO3a)-caspase 8 pathway causes apoptosis in the developing neural tube leading to neural tube defects (NTDs).
[Inhibition of stress-responsive signaling pathway prevents neural cell death following optic nerve injury].
Review
Katome, In Nihon Ganka Gakkai Zasshi, 2014
Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein kinase kinase kinase (MAPKKK) and plays an important role in stress-induced RGC apoptosis.
ASK1 promotes apoptosis of normal and malignant plasma cells.
GeneRIF
Lin et al., Taipei, Taiwan. In Blood, 2012
A novel mechanism underlying the regulation of survival in normal and malignant plasma cells by ASK1.
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress-induced ASK1 activation.
GeneRIF
Zhao et al., Shanghai, China. In Febs Lett, 2012
MCRS2 plays a negative role in stress-induced ASK1 activation.
S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.
GeneRIF
Kobayashi et al., Japan. In J Biol Chem, 2012
S100A1 and permanently active S100P inhibited the apoptosis signal-regulating kinase 1 (ASK1) and PP5 interaction, resulting the inhibition of dephosphorylation of phospho-ASK1 by PP5
TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway.
GeneRIF
Kang et al., Suwŏn, South Korea. In J Biol Chem, 2012
ASK1 and TAK1 function as MAP3 kinases in Cdo-mediated p38MAPK activation to promote myogenic differentiation.
A novel chromone derivative with anti-inflammatory property via inhibition of ROS-dependent activation of TRAF6-ASK1-p38 pathway.
GeneRIF
Xu et al., Nanjing, China. In Plos One, 2011
Results indicate that the anti-inflammatory properties of DCO-6 was through inhibition of reactive oxygen species-dependent activation of TRAF6-ASK1-p38 pathway.
Damage-induced phosphorylation of Sld3 is important to block late origin firing.
Impact
Toczyski et al., San Francisco, United States. In Nature, 2010
Here we show that the replication initiation protein Sld3 is phosphorylated by Rad53, and that this phosphorylation, along with phosphorylation of the Cdc7 kinase regulatory subunit Dbf4, blocks late origin firing in Saccharomyces cerevisiae.
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Impact
Basu et al., Calcutta, India. In Nat Immunol, 2009
TNF activated a pathway involving the kinases ASK1, p38 and c-Abl.
Apoptosis signal-regulating kinase 1 in stress and immune response.
Review
Impact
GeneRIF
Ichijo et al., Tokyo, Japan. In Annu Rev Pharmacol Toxicol, 2007
discusses the molecular mechanisms by which ASK1 functions in stress and immune responses and discuss the possible involvement of ASK1 in human diseases [review]
Mechanism of auxin perception by the TIR1 ubiquitin ligase.
Impact
Zheng et al., Seattle, United States. In Nature, 2007
Here we present the crystal structures of the Arabidopsis TIR1-ASK1 complex, free and in complexes with three different auxin compounds and an Aux/IAA substrate peptide.
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Impact
GeneRIF
Ichijo et al., Tokyo, Japan. In Nat Immunol, 2005
complex of the adaptor molecule TRAF6 and ASK1 and subsequent activation of the ASK1-p38 pathway
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