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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Amiloride-sensitive cation channel 3

ASIC3, acid-sensing ion channel 3, DRASIC
subunit that forms a proton gated Na(+) channel; may play a role in prolonged pain perception [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, ASIC1a, ASIC2, TRPV1, CAN
Papers on ASIC3
NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.
New
Ahring et al., Ballerup, Denmark. In Cns Neurosci Ther, Feb 2016
RESULTS: NS383 inhibited H(+) -activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM.
Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids.
New
Deval et al., Antibes, France. In Embo J, Feb 2016
Here, we show that human painful inflammatory exudates, displaying non-acidic pH, induce a slow constitutive activation of human ASIC3 channels.
Fatigue sensation and gene expression in trained cyclists following a 40 km time trial in the heat.
New
White et al., Salt Lake City, United States. In Eur J Appl Physiol, Jan 2016
Both trials resulted in significant post-exercise decreases in metabolite detecting receptors ASIC3, P2X4, TRPV1, and TRPV4; increases in adrenergic receptors α2a, α2c, and β1; decreases in adrenergic β2, the immune receptor TLR4, and dopamine (DRD4); and increases in serotonin (HTR1D) and IL-10 (p < 0.05).
The role of periodontal ASIC3 in orofacial pain induced by experimental tooth movement in rats.
New
Lai et al., Nanchong, China. In Eur J Orthod, Jan 2016
OBJECTIVES: This study aimed to clarify the roles of Acid-sensing ion channel 3 (ASIC3) in orofacial pain following experimental tooth movement.
Conversed mutagenesis of an inactive peptide to ASIC3 inhibitor for active sites determination.
New
Kozlov et al., Moscow, Russia. In Toxicon, Jan 2016
UNASSIGNED: Peptide Ugr9-1 from the venom of sea anemone Urticina grebelnyi selectively inhibits the ASIC3 channel and significantly reverses inflammatory and acid-induced pain in vivo.
Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Review
New
de Freitas et al., Teresina, Brazil. In Pharmacol Res, Dec 2015
It was thus possible to highlight several researches that have investigated alternatives in order to improve success in the treatment of animal trypanosomiasis, by using new drugs in associations with diminazene aceturate, as well as looking for new pharmacological applications for this compound, such as leishmanicidal, amebicidal, anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent, and mainly as an activator of angiotensin-converting enzyme 2. Another pharmacological property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases.
Ciliated neurons lining the central canal sense both fluid movement and pH through ASIC3.
New
Grillner et al., Stockholm, Sweden. In Nat Commun, Dec 2015
These effects are most likely mediated by ASIC3-channels, since APETx2, a specific antagonist of ASIC3, blocks them both.
Roles of Proton-Sensing Receptors in the Transition from Acute to Chronic Pain.
Review
New
Chen et al., Taiwan. In J Dent Res, Dec 2015
Acid-sensing ion channel 3 (ASIC3) and transient receptor potential/vanilloid receptor subtype 1 (TRPV1) are 2 major acid sensors involved in the proton-induced hyperalgesic priming.
[The Biological Activity of the Sevanol and Its Analogues].
New
Kozlov et al., In Bioorg Khim, Sep 2015
Previously, from the plant Thymus armeniacus a new lignan sevanol was isolated, it's structure was elucidated and was shown that it effectively inhibits the acid-sensing channel ASIC3 and also exhibits a pronounced analgesic and anti-inflammatory effect.
Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems.
Review
New
Lingueglia et al., France. In Neuropharmacology, Jul 2015
Channels containing ASIC3 or ASIC1 subunits, appear to be important in peripheral nociceptors, where they are subject to intense regulation, while ASIC1a-containing channels also have a prominent role in central neurons, including spinal cord neurons that modulate and transmit the pain signal to the brain.
ASICs and cardiovascular homeostasis.
Review
New
Benson et al., Iowa City, United States. In Neuropharmacology, Jul 2015
We identified a role for ASIC2 in the mechano-sensitivity of aortic baroreceptors and of ASIC3 in the pH sensitivity of carotid bodies.
Acid-sensing ion channel (ASIC) 4 predominantly localizes to an early endosome-related organelle upon heterologous expression.
Gründer et al., Aachen, Germany. In Sci Rep, 2014
Six different ASICs have been identified (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, ASIC4) that are activated by a drop in extracellular pH, either as homo- or heteromers.
Research strategies for pain in lumbar radiculopathy focusing on acid-sensing ion channels and their toxins.
Review
Chen et al., Taipei, Taiwan. In Curr Top Med Chem, 2014
ASIC3 is involved in inflammatory pain and ischemic pain, and, likely, mechanical pain.
Acid-Sensing Ion Channels Expression, Identity and Role in the Excitability of the Cochlear Afferent Neurons.
Soto et al., Puebla de Zaragoza, Mexico. In Front Cell Neurosci, 2014
Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N',N'-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3.
Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions.
GeneRIF
Deval et al., France. In Proc Natl Acad Sci U S A, 2012
ASIC3 is able to sense the extracellular pH in both directions and to dynamically adapt its activity between pH 5.0 and 8.0, playing a role in fine tuning neuronal membrane potentials and neuron sensitization in various pH environments.
Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.
Impact
Lazdunski et al., Lyon, France. In Nat Med, 2012
Here we demonstrate that acid-sensing ion channel 3 (Asic3) is an essential neuronal sensor for the vasodilation response to direct pressure in both humans and rodents and for protecting against pressure ulcers in mice.
Eosinophil peroxidase induces the expression and function of acid-sensing ion channel-3 in allergic rhinitis: in vitro evidence in cultured epithelial cells.
GeneRIF
McGarvey et al., Dublin, Ireland. In Clin Exp Allergy, 2012
A mechanism of induction of ASIC-3 expression relevant to AR was suggested by the finding that eosinophil peroxidase (EPO), acting via ERK1/2, induced the expression of ASIC-3 in epithelial cells.
Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.
GeneRIF
Zhou et al., Hefei, China. In J Pediatr Gastroenterol Nutr, 2012
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride.
GeneRIF
Xu et al., Shanghai, China. In J Biol Chem, 2012
Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride
Acid-sensing ion channel 3 mediates peripheral anti-hyperalgesia effects of acupuncture in mice inflammatory pain.
GeneRIF
Lin et al., T'ai-chung-shih, Taiwan. In J Biomed Sci, 2010
the expression of ASIC3 in dorsal root ganglion (DRG) neurons.
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