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Amiloride-sensitive cation channel 1, neuronal

ASIC2, ASIC2a, BNC1, Acid-sensing ion channel 2, ACCN1
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012] (from NCBI)
Papers on ASIC2
Expression of acid-sensing ion channels of gastric mucosa from patients with Henoch-Schönlein purpura.
Zhou et al., Hefei, China. In J Pediatr Gastroenterol Nutr, 2012
The results showed that there was a significant increase in the mean relative optical density of ASIC2 and ASIC3 but not ASIC1a in the lining epithelium and glandular tubes of gastric mucosa in patients with Henoch-Schonlein purpura.
A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene.
Mors et al., Århus, Denmark. In Eur J Hum Genet, 2012
ACCN1 might be one of numerous susceptibility genes for panic disorder.
Fine mapping of dental fluorosis quantitative trait loci in mice.
Zou et al., Chapel Hill, United States. In Eur J Oral Sci, 2011
loss of ACCN1 function does not modify dental fluorosis severity in mice
Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder.
Patrinos et al., Cagliari, Italy. In Pharmacogenomics, 2011
these results indicate that ACCN1 gene is a potential candidate for response to lithium treatment that would serve as a genetic marker of lithium efficacy for bipolar disorder patients.
Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.
Ueta et al., Kitakyūshū, Japan. In J Physiol, 2010
Suggest that interaction between ASICs and lactate in the supraoptic nucleus plays an important role in the regulatory mechanism of body fluid homeostasis.
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