Diminazene aceturate-An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Teresina, Brazil. In Pharmacol Res, Dec 2015
It was thus possible to highlight several researches that have investigated alternatives in order to improve success in the treatment of animal trypanosomiasis, by using new drugs in associations with diminazene aceturate, as well as looking for new pharmacological applications for this compound, such as leishmanicidal, amebicidal, anti-pneumocystis, anti-rheumatoid arthritis, antihypertensive agent, and mainly as an activator of angiotensin-converting enzyme 2. Another pharmacological property still little studied is the inhibition of acid-sensitive ion channels (ASIC1a, ASIC1b, ASIC2a and ASIC3), which are related to the development of various diseases.
Unique roles played by Acid-sensing ion channel 2.
China. In Channels (austin), Dec 2015
They belong to the degenerin/epithelial Na(+) channel family and function once extracellular pH decreases to a certain level, and this characteristic make them spotlights in the regulation or response of pH change.
ASICs and cardiovascular homeostasis.
Iowa City, United States. In Neuropharmacology, Jul 2015
We identified a role for ASIC2 in the mechano-sensitivity of aortic baroreceptors and of ASIC3 in the pH sensitivity of carotid bodies.
Acid-sensing ion channels in gastrointestinal function.
Graz, Austria. In Neuropharmacology, Jul 2015
In the gut, ASICs (ASIC1, ASIC2, ASIC3) are primarily expressed by the peripheral axons of vagal and spinal afferent neurons and are responsible for distinct proton-gated currents in these neurons.
Acid-Sensing Ion Channels Expression, Identity and Role in the Excitability of the Cochlear Afferent Neurons.
Puebla de Zaragoza, Mexico. In Front Cell Neurosci, 2014
Gadolinium and acetylsalicylic acid reduced these currents, and FMRFamide, zinc (at high concentrations) and N,N,N',N'-tetrakis-(2-piridilmetil)-ethylenediamine increased them, indicating that functional ASICs are composed of the subunits ASIC1, ASIC2, and ASIC3.
[Acid-Sensing Ion Channels (ASICs) in pain].
Antibes, France. In Biol Aujourdhui, 2013
The ASIC1 and ASIC3 isoforms are particularly important in sensory neurons, whereas ASIC1a, alone or in association with ASIC2, is essential in the central nervous system.
Black mamba venom peptides target acid-sensing ion channels to abolish pain.
France. In Nature, 2012
Pharmacological inhibition by mambalgins combined with the use of knockdown and knockout animals indicates that blockade of heteromeric channels made of ASIC1a and ASIC2a subunits in central neurons and of ASIC1b-containing channels in nociceptors is involved in the analgesic effect of mambalgins.