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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Asialoglycoprotein receptor 1

Asialoglycoprotein Receptor, hepatic lectin, ASGP-R
acts as a hepatic glycoprotein receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, MUC4, ACID, V1a, Serum albumin
Papers on Asialoglycoprotein Receptor
ASGPR-mediated uptake of multivalent glycoconjugates for drug delivery in hepatocytes.
New
Delangle et al., Grenoble, France. In Chembiochem, Feb 2016
They express the asialoglycoprotein receptor (ASGPR) that promotes specific uptake by means of N-acetylgalactosamine (GalNAc) recognition.
GALACTOSYLATED ALGINATE - CURCUMIN MICELLES FOR ENHANCED DELIVERY OF CURCUMIN TO HEPATOCYTES.
New
K Raj et al., Thiruvananthapuram, India. In Int J Biol Macromol, Feb 2016
UNASSIGNED: Galactosylated alginate-curcumin conjugate (LANH2-Alg Ald-Cur) is synthesized for targeted delivery of curcumin to hepatocytes exploiting asialoglycoprotein receptor (ASGPR) on hepatocytes.
Deciphering the mystery of hepatitis B virus receptors: A historical perspective.
Review
New
Sadia et al., Islamabad, Pakistan. In Virusdisease, Sep 2015
So far, several proteins have been proposed to interact with these different regions of the preS1 domain which includes human immunoglobulin A receptor, glyceraldehyde-3-phosphate dehydrogenase, interleukin-6, a 31-kDa protein, HBV binding factor, asialoglycoprotein receptor, nascent polypeptide-associated complex α polypeptide, lipoprotein lipase, hepatocyte-associated heparan sulfate proteoglycans, glucose-regulated protein 75.
Variation of fibrinogen oligosaccharide structure in the acute phase response: Possible haemorrhagic implications.
New
Brennan, Christchurch, New Zealand. In Bba Clin, Jun 2015
This has two desirable haemostatic outcomes: fibrin monomers will polymerise and form clots more rapidly, and two galactose residues can never be exposed diminishing uptake of the protein by the asialoglycoprotein receptor and ramping up concentration at a time of challenge.
Asialoglycoprotein receptor mediated hepatocyte targeting - strategies and applications.
Review
New
Devarajan et al., Mumbai, India. In J Control Release, May 2015
The asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally on extra-hepatic cells.
Active radar guides missile to its target: receptor-based targeted treatment of hepatocellular carcinoma by nanoparticulate systems.
Review
He et al., Wuhan, China. In Tumour Biol, 2015
In this paper, we reviewed the current status of active targeting strategies for nanoparticulate systems based on various receptors such as asialoglycoprotein receptor, transferrin receptor, epidermal growth factor receptor, folate receptor, integrin, and CD44, which are abundantly expressed on the surfaces of hepatocytes or liver cancer cells.
Cholesterol lowering effects of mono-lactose-appended β-cyclodextrin in Niemann-Pick type C disease-like HepG2 cells.
Arima et al., Kumamoto, Japan. In Beilstein J Org Chem, 2014
Thus, Lac-β-CyD entered NPC-like HepG2 cells via asialoglycoprotein receptor (ASGPR)-mediated endocytosis and decreased the accumulation of intracellular cholesterol in NPC-like HepG2 cells.
Transplantation of hESC-derived hepatocytes protects mice from liver injury.
Dubart-Kupperschmitt et al., Villejuif, France. In Stem Cell Res Ther, 2014
RESULTS: Thirty days post-differentiation, hESCs expressed hepatocyte-specific markers such as asialoglycoprotein receptor and hepatic nuclear factors including HNF4α.
The alpha-fetoprotein third domain receptor binding fragment: in search of scavenger and associated receptor targets.
Review
Mizejewski, Albany, United States. In J Drug Target, 2014
The scavenger receptors (SRs) identified were CD36, CD163, Stabilin, SSC5D, SRB1 and SREC; the SR-associated receptors included the mannose, low-density lipoprotein receptors, the asialoglycoprotein receptor, and the receptor for advanced glycation endproducts (RAGE).
Alcohol, carcinoembryonic antigen processing and colorectal liver metastases.
Review
Casey et al., Omaha, United States. In Adv Exp Med Biol, 2014
It is known that circulating CEA is processed primarily by the liver, first by nonparenchymal Kupffer cells (KCs) and secondarily, by hepatocytes via the asialoglycoprotein receptor (ASGPR).
Dual roles for hepatic lectin receptors in the clearance of chilled platelets.
Impact
Hoffmeister et al., Boston, United States. In Nat Med, 2009
Rapid chilling causes glycoprotein-Ib (GPIb) receptors to cluster on blood platelets.
The Ashwell receptor mitigates the lethal coagulopathy of sepsis.
Impact
Marth et al., San Diego, United States. In Nat Med, 2008
This asialoglycoprotein receptor activity remains a key factor in the development and administration of glycoprotein pharmaceuticals, yet a biological purpose of the Ashwell receptor has remained elusive.
The asialoglycoprotein receptor clears glycoconjugates terminating with sialic acid alpha 2,6GalNAc.
GeneRIF
Baenziger et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2005
Asialoglycoprotein receptor functions to help regulate the concentration of glycoproteins bearing sialic acid alpha 2,6GalNAc in the blood.
Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats.
GeneRIF
Nanji et al., Omaha, United States. In J Appl Physiol, 2004
a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content.
IgA Fc receptors.
Review
Impact
Van De Winkel et al., Paris, France. In Annu Rev Immunol, 2002
These are the asialoglycoprotein receptor and the transferrin receptor, which have been implicated in IgA catabolism, and tissue IgA deposition.
Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon.
Impact
Takahashi et al., Boston, United States. In Nat Med, 1999
Most chronic carriers of hepatitis B virus (HBV) do not respond to interferon (IFN) treatment.
Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals.
Impact
Concia et al., Trento, Italy. In Lancet, 1995
In two of these seven, before EBV infection, there was a defect in suppressor-inducer T lymphocytes specifically controlling immune responses to the asialoglycoprotein receptor, an antigen expressed on the hepatocyte surface.
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