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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ash2

ASH2, Ash2L, BrE2
Top mentioned proteins: Histone, WDR5, SwDI, SET, MLL
Papers using ASH2 antibodies
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex
Supplier
Ma Dzwokai et al., In The Journal of Cell Biology, 1999
... study are mDpy-30 siRNA1–3 (target sequences: siRNA1, 5′-CACCAAATCCCATTGAATT-3′; siRNA2, 5′-AAACGCAGGTTGCAGAAAA-3′; siRNA3, 5′-AGACAACGTTGAGAGAATA-3′; Thermo Fisher Scientific), Ash2L siRNA1 and -2 (target sequences: siRNA1, 5′-CCGAGTAACTAACTTATTTAA-3′; siRNA2, 5′-CCCGTTTAACAAAGATGGCTA-3′; QIAGEN), RbBP5 siRNA1 and -2 ...
The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability.
Supplier
Corominas Montserrat et al., In Genome Biology, 1997
... ash2 transgenic flies, full-length ...
Papers on ASH2
Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling.
New
Xu et al., Nanjing, China. In Int J Biochem Cell Biol, Feb 2016
Further analyses revealed that MRTF-A interacted with and recruited several key epigenetic factors involved in H3K4 methylation, including ASH2, WDR5, and SET1, to the promoters of pro-fibrogenic genes in response to TGF-β treatment.
MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription.
New
Xu et al., Nanjing, China. In Oncogene, Nov 2015
Further analyses revealed that MKL1 recruited ASH2, a component of the H3K4 methyltransferase complex, to activate MMP9 transcription.
Unique Role of the WD-40 Repeat Protein 5 (WDR5) Subunit within the Mixed Lineage Leukemia 3 (MLL3) Histone Methyltransferase Complex.
New
Cosgrove et al., Syracuse, United States. In J Biol Chem, Nov 2015
The human SET1 family includes MLL1-4 and SETd1A/B, which all interact with a conserved subcomplex containing WDR5, RbBP5, Ash2L, and DPY-30 (WRAD) to form the minimal core complex required for full methyltransferase activity.
Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.
New
Howitz et al., Great Malvern, United Kingdom. In Assay Drug Dev Technol, May 2015
The MLL/SET1 family members are most enzymatically active when part of a "core complex," the catalytic SET-domain-containing subunits bound to a subcomplex consisting of the proteins WDR5, RbBP5, Ash2L and a homodimer of DPY-30 (WRAD2).
EGFR promoter exhibits dynamic histone modifications and binding of ASH2L and P300 in human germinal matrix and gliomas.
Tsankova et al., New York City, United States. In Epigenetics, 2014
Furthermore, the histone methyltransferase core enzyme ASH2L was bound at EGFR in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 was bound in samples with H3K27ac enrichment.
Triptolide Induces Cell Apoptosis by Targeting H3K4me3 and Downstream Effector Proteins in KM3 Multiple Myeloma Cells.
Zhang et al., Wuhan, China. In Curr Pharm Biotechnol, 2014
Treatment of KM3 cells with triptolide and siRNA targeting ASH2L reduced the expression of c-Myc and VEGFA.
Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination.
Review
Géli et al., Marseille, France. In Epigenetics, 2013
In Saccharomyces cerevisiae, all H3K4 methylation is performed by a single Set1 Complex (Set1C) that is composed of the catalytic (Set1) and seven other subunits (Swd1, Swd2, Swd3, Bre2, Sdc1, Spp1 and Shg1).
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.
Impact
Rudnicki et al., Ottawa, Canada. In Cell Stem Cell, 2012
Methylated Pax7 directly binds the C-terminal cleavage forms of the trithorax proteins MLL1/2 resulting in the recruitment of the ASH2L:MLL1/2:WDR5:RBBP5 histone H3K4 methyltransferase complex to regulatory enhancers and the proximal promoter of Myf5.
WRAD: enabler of the SET1-family of H3K4 methyltransferases.
Review
Vakoc et al., United States. In Brief Funct Genomics, 2012
Unlike most lysine methyltransferases, SET1-family enzymes are only fully active in the context of a multi-subunit complex, which includes a protein module comprised of WDR5, RbBP5, ASH2L and DPY-30 (WRAD).
Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
GeneRIF
Lei et al., In Cell Res, 2012
crystal structure of the C-terminal SPRY domain of human Ash2L
Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.
GeneRIF
Lei et al., Ann Arbor, United States. In Embo Rep, 2011
The structure shows that Ash2L contains an atypical PHD finger that does not have histone tail-binding activity.
Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.
GeneRIF
Couture et al., Ottawa, Canada. In Nat Struct Mol Biol, 2011
ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain.
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.
GeneRIF
Dent et al., United States. In J Biol Chem, 2011
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.
NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters.
GeneRIF
Mantovani et al., Milano, Italy. In Plos One, 2010
NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L
Regulating a master regulator: establishing tissue-specific gene expression in skeletal muscle.
Review
Dilworth et al., Ottawa, Canada. In Epigenetics, 2010
Based on studies of the muscle-specific myog gene, we propose a model where the transcriptional activators Mef2d and Six4 mediate recruitment of Trithorax Group proteins Ash2L/MLL2 and UTX to MyoD-bound promoters to overcome the Polycomb-mediated repression of muscle genes.
Exploring the Reactivity Trends in the E2 and SN2 Reactions of X(-) + CH3CH2Cl (X = F, Cl, Br, HO, HS, HSe, NH2 PH2, AsH2, CH3, SiH3, and GeH3).
Li et al., Hong Kong, Hong Kong. In J Chem Theory Comput, 2009
The reactions studied are X(-) + CH3CH2Cl → HX + CH2═CH2 + Cl(-) and X(-) + CH3CH2Cl → CH3CH2X + Cl(-), with X = F, Cl, Br, HO, HS, HSe, NH2 PH2, AsH2, CH3, SiH3, and GeH3.
Pax7 activates myogenic genes by recruitment of a histone methyltransferase complex.
Impact
Rudnicki et al., Ottawa, Canada. In Nat Cell Biol, 2008
This revealed that Pax7 associates with the Wdr5-Ash2L-MLL2 histone methyltransferase (HMT) complex that directs methylation of histone H3 lysine 4 (H3K4, refs 4-10).
The molecular regulation of muscle stem cell function.
Review
Kuang et al., Ottawa, Canada. In Cold Spring Harb Symp Quant Biol, 2007
Pax7 activates expression of target genes such as Myf5 and MyoD through recruitment of the Wdr5/Ash2L/MLL2 histone methyltransferase complex.
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.
Impact
Amati et al., Milano, Italy. In Nature, 2007
Conversely, the H3R2me2a mark prevented methylation of H3K4 as well as binding to the H3 tail by an ASH2/WDR5/MLL-family methyltransferase complex.
Relationship between SPRY and B30.2 protein domains. Evolution of a component of immune defence?
Review
Trowsdale et al., Cambridge, United Kingdom. In Immunology, 2005
Collectively, proteins containing SPRY and B30.2 domains cover a wide range of functions, including regulation of cytokine signalling (SOCS), RNA metabolism (DDX1, hnRNPs), intracellular calcium release (RyR receptors), immunity to retroviruses (TRIM5alpha) as well as regulatory and developmental processes (HERC1, Ash2L).
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