The pathogenic role of the inflammasome in neurodegenerative diseases.
Chapel Hill, United States. In J Neurochem, Jul 2015
UNASSIGNED: The inflammasome is a large macromolecular complex that contains multiple copies of a receptor or sensor of pathogen-derived or damage-derived molecular patterns, pro-caspase-1, and an adaptor called ASC (apoptotic speck containing protein with a CARD), which results in caspase-1 maturation.
[Inflammasome: activation mechanisms].
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In Invest Clin, Mar 2015
In addition, the inflammasome is formed by the speck-like protein associated to apoptosis (ASC) and procaspase-1, that may be activated by variations in the ionic and intracellular and extracellular ATP concentrations; and the loss of stabilization of the fagolisosomme by internalization of insoluble crystals and redox mechanisms.