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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Steroid sulfatase

ASC, steroid sulfatase, Steryl-Sulfatase
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, CAN, V1a, HAD, IL-18
Papers using ASC antibodies
NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant
Lang Carol J. et al., In Journal of Allergy, 2010
... Other rabbit Abs were ASC from Abcam (Cambridge, UK), CCR3 from ...
Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.
Combs Colin, In PLoS ONE, 2009
... Western blot analysis, the antibodies against IL-1β was from Cell Signaling Technology (Beverly, MA); against ASC and pro-IL-1β, from Santa Cruz Biotechnology; against NLRP3, from Sigma-Aldrich; ...
WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport
Mullins R. Dyche et al., In Nature cell biology, 2007
... was supported by grants from the NIH, the American Heart Association Predoctoral Fellowship (JBZ), MRC-Funding (ASC), and the Burroughs-Wellcome Fund Career Award in the Biomedical Sciences Fellowship (MEQ) ...
Quality control of photosystem II: cleavage of reaction center D1 protein in spinach thylakoids by FtsH protease under moderate heat stress
Garab Győző et al., In Plant Physiology, 2005
... mutants are affected in the Gal pathway of Asc biosynthesis, more specifically in GDP- ...
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition
Taniguchi Shun'ichiro et al., In Mediators of Inflammation, 2002
... ASC and an unidentified Protein X separated by SDS–PAGE using antihuman ASC monoclonal antibody (MBL, Nagoya, Japan) were excised ...
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Papers on ASC
Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition.
Lai et al., Toronto, Canada. In J Child Psychol Psychiatry, Feb 2016
BACKGROUND: Although autism spectrum condition (ASC) is strongly genetic in origin, accumulating evidence points to the critical roles of various environmental influences on its emergence and subsequent developmental course.
Glycolic Acid Silences Inflammasome Complex Genes, NLRC4 and ASC, by Inducing DNA Methylation in HaCaT Cells.
Yang et al., Taiwan. In Dna Cell Biol, Feb 2016
We evaluated NLRP3, NLRC4, AIM2, and ASC inflammasome complex gene expression on real-time polymerase chain reaction (PCR).
Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner.
Han et al., Jinan, China. In Joint Bone Spine, Feb 2016
In neutrophils, protein expression of NLRP3, apoptosis associated speck-like protein containing a CARD (ASC) and pro-caspase-1 was significantly decreased, while protein expression of activated caspase-1 was significantly increased and positively correlated with DAS28-CRP.
Gossypol induces pyroptosis in mouse macrophages via a non-canonical inflammasome pathway.
He et al., Guangzhou, China. In Toxicol Appl Pharmacol, Feb 2016
Besides, RAW 264.7 cells lacking ASC expression and caspase-1 activation also underwent pyroptotic cell death upon gossypol treatment.
In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity.
Bousso et al., Paris, France. In Nat Med, Jan 2016
We show that modified vaccinia Ankara virus induces inflammasome activation in subcapsular sinus (SCS) macrophages, which is immediately followed by cell death and release of extracellular ASC specks.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Beutler et al., Dallas, United States. In Nat Immunol, Jan 2016
This interaction was necessary for the formation of a complex containing NLRP3 and the adaptor ASC, oligomerization of ASC and activation of caspase-1.
Expression of Nucleotide-oligomerization Domain (NOD) and Related Genes in Mouse Tissues Infected with Mycobacterium leprae.
Kang et al., Seoul, South Korea. In Immune Netw, Dec 2015
The mRNA expression of NOD1, NOD2, caspase-1 and ASC was increased in mouse footpads.
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 expression.
Wu et al., Taipei, Taiwan. In J Biomed Sci, Dec 2015
RESULT: ASC transplantation significantly improved the survival rate of mice with ALF and attenuated the severity of APAP-induced liver damage by suppressing cytochrome P450 activity to reduce the accumulation of toxic nitrotyrosine and the upregulation of NF-E2-related factor 2 (Nrf2) expression, resulting in an increase in the subsequent antioxidant activity.
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
O'Riordan et al., Ann Arbor, United States. In Immunity, Oct 2015
Here we have used an infection model to show that the IRE1α ER stress sensor regulates regulated mitochondrial dysfunction through an NLRP3-mediated feed-forward loop, independently of ASC.
The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.
Stehlik et al., Chicago, United States. In Immunity, Sep 2015
In response to infections and tissue damage, ASC-containing inflammasome protein complexes are assembled that promote caspase-1 activation, IL-1β and IL-18 processing and release, pyroptosis, and the release of ASC particles.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Ting et al., Chapel Hill, United States. In Nat Med, Aug 2015
We found that Aim2-deficient mice had greater tumor load than Asc-deficient mice in the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colorectal cancer.
The two faces of the inflammasome adaptor ASC in epithelial skin carcinogenesis.
Drexler et al., Tübingen, Germany. In Clin Exp Rheumatol, Jul 2015
In this short review we discuss current knowledge on the role of inflammasomes in epithelial cancer of the gut and skin with a special focus on the complex role of the inflammasome adaptor ASC in epithelial skin carcinogenesis.
Inflammasomes and human autoimmunity: A comprehensive review.
Chiang et al., Taiwan. In J Autoimmun, Jul 2015
Inflammasomes are multi-protein complexes composed of a NOD-like receptor (NLR)/an AIM-like receptor (ALR), the adapter molecule apoptosis-associated speck-like protein that contains a CARD (ASC), and caspase-1.
The pathogenic role of the inflammasome in neurodegenerative diseases.
Ting et al., Chapel Hill, United States. In J Neurochem, Jul 2015
UNASSIGNED: The inflammasome is a large macromolecular complex that contains multiple copies of a receptor or sensor of pathogen-derived or damage-derived molecular patterns, pro-caspase-1, and an adaptor called ASC (apoptotic speck containing protein with a CARD), which results in caspase-1 maturation.
[Inflammasome: activation mechanisms].
Buelvas et al., In Invest Clin, Mar 2015
In addition, the inflammasome is formed by the speck-like protein associated to apoptosis (ASC) and procaspase-1, that may be activated by variations in the ionic and intracellular and extracellular ATP concentrations; and the loss of stabilization of the fagolisosomme by internalization of insoluble crystals and redox mechanisms.
Activation of Nod-like receptor protein 3 inflammasomes turns on podocyte injury and glomerular sclerosis in hyperhomocysteinemia.
Li et al., Richmond, United States. In Hypertension, 2012
Data show that podocytes expressed 3 essential components of the NALP3 inflammasome complex, namely, NALP3, ASC, and caspase 1.
Altered serotonergic function may partially account for behavioral endophenotypes in steroid sulfatase-deficient mice.
Davies et al., Cardiff, United Kingdom. In Neuropsychopharmacology, 2012
These data suggest that inactivating mutations and functional variants within STS might exert their influence on ADHD vulnerability, and disorder endophenotypes through modulation of the serotonergic system.
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response.
Mehal et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
The acute inflammatory response to biomaterials requires nucleotide-binding domain and leucine-rich repeat-containing 3 (Nlrp3), apoptosis-associated speck-like protein containing CARD (Asc), and caspase-1.
Correlation between promoter methylation of p14(ARF), TMS1/ASC, and DAPK, and p53 mutation with prognosis in cholangiocarcinoma.
Hailong et al., Yantai, China. In World J Surg Oncol, 2011
Hypermethylation of ASC is associated with cholangiocarcinoma.
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection.
Bose et al., San Antonio, United States. In Plos One, 2011
the requirement of TLR2/MyD88/NF-kappaB pathway (first signal) and ROS/potassium efflux (second signal) for NLRP3/ASC inflammasome formation, leading to caspase-1 activation and subsequent IL-1beta release during RSV infection
More papers using ASC antibodies
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
Bielinsky Anja-Katrin, In PLoS ONE, 1995
... AscI (New England Biolabs, Ipswich, MA) and the ...
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