Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development.
Vienna, Austria. In Curr Diabetes Rev, 2014
The new drug classes described include PPAR agonists/modulators, glucokinase activators, glucagon receptor antagonists, anti-inflammatory compounds, G-protein coupled receptor agonists, gastrointestinal peptide agonists other than GLP-1, apical sodium-dependent bile acid transporter (ASBT) inhibitors, SGLT1 and dual SGLT1/SGLT2 inhibitors, and 11beta- HSD1 inhibitors.
Structural basis of the alternating-access mechanism in a bile acid transporter.
Houston, United States. In Nature, 2014
In humans, there are two Na(+)-dependent bile acid transporters involved in enterohepatic recirculation, the Na(+)-taurocholate co-transporting polypeptide (NTCP; also known as SLC10A1) expressed in hepatocytes, and the apical sodium-dependent bile acid transporter (ASBT; also known as SLC10A2) expressed on enterocytes in the terminal ileum.
A review of the JR blood group system.
Campinas, Brazil. In Immunohematology, 2012
The JR blood group system (ISBT 032) consists of one antigen,Jra, which is of high prevalence in all populations.
Bile salt transporters: molecular characterization, function, and regulation.
Graz, Austria. In Physiol Rev, 2003
The bile salt pool undergoes an enterohepatic circulation that is regulated by distinct bile salt transport proteins, including the canalicular bile salt export pump BSEP (ABCB11), the ileal Na(+)-dependent bile salt transporter ISBT (SLC10A2), and the hepatic sinusoidal Na(+)- taurocholate cotransporting polypeptide NTCP (SLC10A1).