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Ankyrin repeat and SOCS box containing 6

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011] (from NCBI)
Top mentioned proteins: Aps, Insulin, ACID, Cbl, CIs
Papers on Asb6
Asb6 upregulation by Areca nut extracts is associated with betel quid-induced oral carcinogenesis.
Lo et al., Taipei, Taiwan. In Oral Oncol, 2009
Here, we identified the upregulation of Asb6, a coupling protein to the APS adapter protein, which is involved in insulin signaling for glucose transportation, of normal keratinocytes and oral cancer cells under ANE treatment.
Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.
Pillay et al., Nottingham, United Kingdom. In J Biol Chem, 2004
Yeast two-hybrid screening of a 3T3-L1 adipocyte library using APS as a bait identified a 418-amino acid ankyrin and SOCS (suppressor of cytokine signaling) box protein Asb6 as an interactor.
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