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Ankyrin repeat and SOCS box-containing 9

This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009] (from NCBI)
Top mentioned proteins: CIs, Ubiquitin, Cullin, OUT, HAD
Papers on Asb-9
How the ankyrin and SOCS box protein, ASB9, binds to creatine kinase.
Komives et al., San Diego, United States. In Biochemistry, Apr 2015
ASB9 binds to creatine kinase (CK) and targets it for degradation; however, the way in which ASB9 interacts with CK is not yet known.
High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.
Ikeda et al., Tokyo, Japan. In Int J Cancer, 2014
Transient overexpression of ankyrin repeat and suppressor of cytokine signaling box protein 9 (ASB9) reduced uMtCK protein levels in HCC cells, suggesting that increased uMtCK levels in HCC cells may be caused by increased gene expression and decreased protein degradation due to reduced ASB9 expression.
Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.
Bullock et al., Oxford, United Kingdom. In J Mol Biol, 2013
We determined the crystal structures of the ternary complex of ASB9-Elongin B/C as well as the interacting N-terminal domain of Cul5 and used structural comparisons to establish a model for the complete Cul5-based E3 ligase.
Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
Ciulli et al., Cambridge, United Kingdom. In Biochemistry, 2013
To enhance our understanding of ASB CRL systems, we investigated the structure, affinity, and assembly of the quaternary multisubunit complex formed by ASB9, Elongin B, Elongin C (EloBC), and Cullin 5. Here, we describe the application of several biophysical techniques including differential scanning fluorimetry, isothermal titration calorimetry (ITC), nanoelectrospray ionization, and ion-mobility mass spectrometry (IM-MS) to provide structural and thermodynamic information for a quaternary ASB CRL complex.
Crystal structure of Human ASB9-2 and substrate-recognition of CKB.
Ji et al., Shanghai, China. In Protein J, 2012
His103 and Phe107 in hASB9-2 are essential for binding to CKB.
Computational simulations to predict creatine kinase-associated factors: protein-protein interaction studies of brain and muscle types of creatine kinases.
Meng et al., Jiaxing, China. In Enzyme Res, 2010
Among them, several hub proteins such as NFKB1, FHL2, MYOC, and ASB9 were predicted.
Autoantibodies to tailor-made panels of tumor-associated antigens in breast carcinoma.
Piura et al., Tel Aviv-Yafo, Israel. In J Oncol, 2010
So far, AAb assays to the following tailor-made panels of TAAs have been assessed in breast carcinoma: (1) p53, c-myc, HER2, NY-ESO-1, BRCA2, and MUC1, (2) IMP1, p62, Koc, p53, c-MYC, cyclin B1, and survivin, (3) PPIA, PRDX2, FKBP52, HSP-60, and MUC1, (4) MUC1, HER2, p53, and IGFBP2, (5) p53, HER2, IGFBP-2, and TOPO2α, (6) survivin and livin, (7) ASB-9, SERAC1, and RELT, and (8) p16, p53, and c-myc.
Clinical significance of ASB9 in human colorectal cancer.
Mori et al., Suita, Japan. In Int J Oncol, 2010
The results of the present study suggest that ASB9 is a useful prognostic marker for colorectal cancer
ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function.
Kwon et al., South Korea. In Bmc Biol, 2009
ASB9 interacts with the creatine kinase system and negatively regulates cell growth.
Expression of murine Asb-9 during mouse spermatogenesis.
Kim et al., Seoul, South Korea. In Mol Cells, 2009
mAsb-9 could be a specific marker of active spermatogenesis and would be useful for studies of male germ cell development.
Crystallization and preliminary X-ray analysis of the splice variant of human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9-2).
Ji et al., Shanghai, China. In Protein Pept Lett, 2008
The purified ASB9-2 protein, the splice variant of ASB9 with only one ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution.
Autoantibodies as potential biomarkers for breast cancer.
Kernstine et al., Baoding, China. In Breast Cancer Res, 2007
BLAST results of the three proteins showed great matches to ASB-9, SERAC1, and RELT.
Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation.
Hilton et al., Australia. In J Biol Chem, 2007
creatine kinase B (CKB) interacts with Asb-9 in a specific, SOCS box-independent manner
Comparative integromics on VEGF family members.
Katoh et al., Japan. In Int J Oncol, 2006
ASB9-ASB11-VEGFD locus at human chromosome Xp22.2
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