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proteins. Page last changed on 08 Dec 2016.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASAP3, ACAP4, DDEFL1, ARF6 GTPase-activating protein, development and differentiation enhancing factor-like 1
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from
Wittinghofer et al., Dortmund, Germany. In Cell, 2010
The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.