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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

ASAP3, ACAP4, DDEFL1, ARF6 GTPase-activating protein, development and differentiation enhancing factor-like 1
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from NCBI)
Papers on ASAP3
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
GeneRIF
Yao et al., Hefei, China. In J Biol Chem, 2012
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
Impact
GeneRIF
Wittinghofer et al., Dortmund, Germany. In Cell, 2010
The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
GeneRIF
Randazzo et al., Bethesda, United States. In J Biol Chem, 2008
ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
GeneRIF
Yao et al., Hefei, China. In Mol Cell Proteomics, 2006
ACAP4 is involved in ARF6-mediated cell migration.
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