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ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

ASAP3, ACAP4, DDEFL1, ARF6 GTPase-activating protein, development and differentiation enhancing factor-like 1
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: ARF6, S19, p16, Actin, GAP
Papers on ASAP3
Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration.
Yang et al., Chongqing, China. In Mol Med Report, 2014
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 (ASAP3), previously known as ACAP4, DDEFL1 and UPLC1, is considered to be an important regulator in cancer cell migration/invasion and actin-based cytoskeletal remodeling.
ASAP3 expression in non-small cell lung cancer: association with cancer development and patients' clinical outcome.
Wang et al., In Tumour Biol, 2014
ASAP3 belongs to Arf-specific GTPase-activating proteins which regulate Arfs by stimulating their intrinsic GTP hydrolysis.
Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.
Yao et al., Hefei, China. In Proc Natl Acad Sci U S A, 2013
ArfGAP With Coiled-Coil, Ankyrin Repeat And PH Domains 4 (ACAP4) is an ADP-ribosylation factor 6 (ARF6) GTPase-activating protein essential for EGF-elicited cell migration.
Nonresectoscopic endometrial ablation in high-risk surgical patients: a cohort study.
Famuyide et al., Rochester, United States. In J Minim Invasive Gynecol, 2013
The ASA classification includes 6 grades: ASAP1, a normal healthy person; ASAP2, mild systemic disease; ASAP3, severe systemic disease; ASAP4, severe systemic disease that is a constant threat to life; ASAP5, a critically ill patient who is not expected to survive without the operation; and ASAP6, declared brain-dead patient whose organs are being removed for donor purposes.
Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia.
Satake et al., Sendai, Japan. In J Clin Invest, 2013
We previously identified SMAP1 as an ARF6 GTPase-activating protein that functions in clathrin-dependent endocytosis.
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
Yao et al., Hefei, China. In J Biol Chem, 2012
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin beta1 recycling in cell migration
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
Araki et al., Japan. In J Cell Sci, 2011
Furthermore, GTP-Rab35-dependent recruitment of ACAP2, an ARF6 GTPase-activating protein, was shown in the phagocytic cup formation.
Phospho-regulated ACAP4-Ezrin interaction is essential for histamine-stimulated parietal cell secretion.
Yao et al., Hefei, China. In J Biol Chem, 2010
Our recent proteomic study revealed a protein complex of ezrin-ACAP4-ARF6 essential for volatile membrane remodeling (Fang, Z., Miao, Y., Ding, X., Deng, H., Liu, S., Wang, F., Zhou, R., Watson, C., Fu, C., Hu, Q., Lillard, J. W., Jr., Powell, M., Chen, Y., Forte, J. G., and Yao, X. (2006) Mol.
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
Wittinghofer et al., Dortmund, Germany. In Cell, 2010
The ArfGAP catalytic mechanism and shows a glutamine from Arf6 and an arginine fingerASAP3 as the important catalytic residues; unexpectedly the structure shows a calcium ion, liganded by both proteins in the complex interface.
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion.
Randazzo et al., Bethesda, United States. In J Biol Chem, 2008
ASAP3 functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
Diversity and divergence patterns in regulatory genes suggest differential gene flow in recently derived species of the Hawaiian silversword alliance adaptive radiation (Asteraceae).
Purugganan et al., United States. In Mol Ecol, 2007
To examine how historical population size and gene flow patterns within and between loci have influenced lineage divergence in the Hawaiian silversword alliance, we have investigated the nucleotide sequence diversity and divergence patterns of four floral regulatory genes (ASAP1-A, ASAP1-B, ASAP3-A, ASAP3-B) and a structural gene (ASCAB9).
Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
Yao et al., Hefei, China. In Mol Cell Proteomics, 2006
ACAP4 is involved in ARF6-mediated cell migration.
Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1.
Vitale et al., Strasbourg, France. In J Biol Chem, 2006
Neuroendocrine cells release hormones and neuropeptides by exocytosis, a highly regulated process in which secretory granules fuse with the plasma membrane to release their contents in response to a calcium trigger.
An effector domain mutant of Arf6 implicates phospholipase D in endosomal membrane recycling.
Donaldson et al., Bethesda, United States. In Mol Biol Cell, 2006
Additionally, unlike wild-type Arf6, neither Arf6 mutant could generate protrusions or recruit the Arf6 GTPase activating protein (GAP) ACAP1 onto the endosome in the presence of aluminum fluoride.
Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas.
Nakamura et al., Tokyo, Japan. In Int J Oncol, 2004
termed DDEFL1 (development and differentiation enhancing factor-like 1), encoding a product that shared structural features with centaurin-family proteins.
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