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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


AS3MT, cyt19, arsenite methyltransferase, S-Adenosyl-l-methionine:arsenic(III) methyltransferase
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, AGE
Papers on AS3MT
Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT).
Rosen et al., Miami, United States. In Chem Res Toxicol, Jan 2016
Arsenic is the most ubiquitous environmental toxin and carcinogen.
Determinants and consequences of arsenic metabolism efficiency among 4,794 individuals: demographics, lifestyle, genetics, and toxicity.
Ahsan et al., Bangladesh. In Cancer Epidemiol Biomarkers Prev, Jan 2016
BACKGROUND: Exposure to inorganic arsenic (iAs), class I carcinogen, affects several hundred-million people worldwide.
Linkage Analysis of Urine Arsenic Species Patterns in the Strong Heart Family Study.
Navas-Acien et al., Valencia, Spain. In Toxicol Sci, Nov 2015
We also examined the contribution of polymorphisms in the arsenic metabolism gene AS3MT via conditional linkage analysis.
Positive selection of AS3MT to arsenic water in Andean populations.
Mormina et al., Cambridge, United Kingdom. In Mutat Res, Oct 2015
We identified a strong signal of positive selection in the main arsenic methyltransferase AS3MT gene, which has been previously associated with lower concentrations of the most toxic product of arsenic metabolism monomethylarsonic acid.
Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele.
Christiani et al., Dhaka, Bangladesh. In Birth Defects Res A Clin Mol Teratol, Sep 2015
RESULTS: Drinking water inorganic arsenic concentration was associated with increased risk of myelomeningocele for participants with 4 of the 14 studied single-nucleotide polymorphisms in genes involved in folate metabolism: the AA/AG genotype of rs2236225 (MTHFD1), the GG genotype of rs1051266 (SLC19A1), the TT genotype of rs7560488 (DNMT3A), and the GG genotype of rs3740393 (AS3MT) with adjusted odds ratio of 1.13, 1.31, 1.20, and 1.25 for rs2236225, rs1051266, rs7560488, and rs3740393, respectively.
Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency.
Hernández et al., Barcelona, Spain. In Mutat Res, Sep 2015
As an attempt to eliminate i-As associated toxicity, chronically exposed MEF Ogg1(-/-) cells overexpress the arsenic metabolizing enzyme As3mt.
Interactive Effects of N6AMT1 and As3MT in Arsenic Biomethylation.
Ren et al., Buffalo, United States. In Toxicol Sci, Aug 2015
In humans, arsenic is primarily metabolized by arsenic (+3 oxidation state) methyltransferase (As3MT) to yield both trivalent and pentavalent methylated metabolites.
Arsenic(+3) and DNA methyltransferases, and arsenic speciation in tadpole and frog life stages of western clawed frogs (Silurana tropicalis) exposed to arsenate.
Cullen et al., Canada. In Metallomics, Aug 2015
The effects were assessed by measuring arsenic(+3) and DNA methyltransferases (AS3MT and DNMT1), as well as As speciation in the tissues.
High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity.
Rosen et al., Miami, United States. In Anal Biochem, Aug 2015
As(III) S-adenosylmethionine methyltransferases (AS3MT in mammals and ArsM in microbes) methylate As(III) three times in consecutive steps and play a central role in arsenic metabolism from bacteria to humans.
[Relationship between Arsenic (+3 Oxidation State) Methyltransferase Genetic Polymorphisms and Methylation Capacity of Inorganic Arsenic].
Iwata et al., Japan. In Nihon Eiseigaku Zasshi, 2014
Genetic polymorphisms such as single nucleotide polymorphisms (SNPs) in arsenic (+3 oxidation state) methyltransferase (AS3MT), which can methylate arsenic compounds using S-adenosyl-l-methionine (AdoMet), have been reported to modify arsenic methylation.
As(III) S-adenosylmethionine methyltransferases and other arsenic binding proteins.
Rosen et al., India. In Geomicrobiol J, 2014
UNASSIGNED: Efflux is by far the most common means of arsenic detoxification is by methylation catalyzed by a family of As(III) S-adenosylmethionine (SAM) methyltransferases (MTs) enzymes designated ArsM in microbes or AS3MT in higher eukaryotes.
Arsenic and selenium toxicity and their interactive effects in humans.
Ma et al., Nanjing, China. In Environ Int, 2014
Arsenic (As) and selenium (Se) are unusual metalloids as they both induce and cure cancer.
AS3MT, GSTO, and PNP polymorphisms: impact on arsenic methylation and implications for disease susceptibility.
Cowden et al., United States. In Environ Res, 2014
The genes we examined were arsenic (+3) methyltransferase (AS3MT), glutathione-s-transferase omega (GSTO), and purine nucleoside phosphorylase (PNP).
Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders.
State et al., San Francisco, United States. In Int J Epidemiol, 2014
These include variations in chromosomal structure at 16p11.2, rare de novo point mutations at the gene SCN2A, and common single nucleotide polymorphisms (SNPs) mapping near loci encoding the genes ITIH3, AS3MT, CACNA1C and CACNB2.
Pregnancy and the methyltransferase genotype independently influence the arsenic methylation phenotype.
Vahter et al., Stockholm, Sweden. In Pharmacogenet Genomics, 2012
Pregnancy and the AS3MT genotype independently influence the arsenic methylation phenotype
GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.
Christiani et al., Boston, United States. In Biomarkers, 2012
Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion
Low-level arsenic exposure, AS3MT gene polymorphism and cardiovascular diseases in rural Texas counties.
O'Bryant et al., Lubbock, United States. In Environ Res, 2012
Coronary heart disease and its main risk factors were associated with low-level arsenic exposure, AS3MT polymorphism or both. Hypertension was associated with higher arsenic exposure, while hyperlipidemia was associated AS3MT polymorphism.
Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity.
Himeno et al., Tokushima, Japan. In Biol Pharm Bull, 2011
In 2002, arsenite (+3 oxidation state) methyltransferase (As3MT) was discovered to be an enzyme responsible for arsenic methylation.
Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase.
Himeno et al., Tokushima, Japan. In Biochem Biophys Res Commun, 2011
These data suggest that the expression pattern of splicing variants of the As3MT gene may affect the capacity for arsenic methylation in cells.
Analysis of arsenic metabolites in HepG2 and AS3MT-transfected cells.
Hirano et al., Chiba, Japan. In Arch Toxicol, 2011
investigation of the roles of AS3MT in the effects of arsenicals, carcinogens found ubiquitously in nature: metabolism, toxicity, and accumulation of arsenicals in hepatocytes
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