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PDS5, regulator of cohesion maintenance, homolog B

As3
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: HAD, CAN, Transcription Factor DP1, ACID, fibrillin-1
Papers on As3
Photoinduced excited state intramolecular proton transfer and spectral behaviors of Aloesaponarin 1.
New
Sun et al., Xinxiang, China. In Spectrochim Acta A Mol Biomol Spectrosc, Jan 2016
The fluorescence peaks of AS1 (636nm), AS2 (Aloesaponarin 1 3-O-methyl ether, 629 nm) and AS3 (Aloesaponarin 1 8-O-methyl ether, 522 nm) demonstrate that the fluorescence behavior of AS1 is primarily effected by HB1 rather than HB2.
Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach.
New
Dumont et al., United States. In Transfusion, Dec 2015
Routine storage practices can be ameliorated through the implementation of novel additive solutions (ASs) that tackle the accumulation of biochemical and morphologic lesion during routine cold liquid storage in the blood bank, such as the recently introduced alkaline solution AS-7.
Talaromyces neofusisporus and T. qii, two new species of section Talaromyces isolated from plant leaves in Tibet, China.
New
Wang et al., Beijing, China. In Sci Rep, Dec 2015
Two new species isolated from plant leaves belonging to Talaromyces section Talaromyces are reported, namely T. neofusisporus (ex-type AS3.15415 (T) = CBS 139516 (T)) and T. qii (ex-type AS3.15414 (T) = CBS 139515 (T)).
CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions.
New
Yoshida et al., Bethesda, United States. In Transfusion, Nov 2015
BACKGROUND: Anaerobic red blood cell (RBC) storage reduces oxidative damage, maintains adenosine triphosphate (ATP) and 2,3-diphosphoglycerate (DPG) levels, and has superior 24-hour recovery at 6 weeks compared to standard storage.
Hemoglobin oxidation at functional amino acid residues during routine storage of red blood cells.
New
Hansen et al., San Francisco, United States. In Transfusion, Nov 2015
STUDY DESIGN AND METHODS: Five AS-3 units were analyzed during routine storage via one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis-nano-high-performance liquid chromatography coupled online with tandem mass spectrometry and advanced database searches.
Routine storage of red blood cell (RBC) units in additive solution-3: a comprehensive investigation of the RBC metabolome.
New
Hansen et al., Aurora, United States. In Transfusion, Jun 2015
In addition to energy and redox metabolism impairment, intra- and extracellular accumulation of amino acids was observed proportionally to storage duration, suggesting a role for glutamine and serine metabolism in aging RBCs.
Differences in Rat and Human Erythrocytes Following Blood Component Manufacturing: The Effect of Additive Solutions.
New
Holovati et al., Edmonton, Canada. In Transfus Med Hemother, May 2015
METHODS: Blood from Sprague-Dawley rats and human volunteers (n = 6) was collected in CPD anticoagulant, resuspended in SAGM or AS3, and leukoreduced.
Enrichment of human hematopoietic stem/progenitor cells facilitates transduction for stem cell gene therapy.
New
Kohn et al., Los Angeles, United States. In Stem Cells, May 2015
CD34(+) /CD38(-) cells, comprising ∼1%-3% of all CD34(+) cells, were isolated from healthy cord blood CD34(+) cells by fluorescence-activated cell sorting and transduced with a lentiviral vector expressing an antisickling form of beta-globin (CCL-β(AS3) -FB).
Prolonged post-thaw shelf life of red cells frozen without prefreeze removal of excess glycerol.
New
Lagerberg et al., Netherlands. In Vox Sang, Apr 2015
The aim of this study was to investigate the influence of supernatant glycerol reduction before freezing on the stability of thawed, deglycerolized RBCs during subsequent cold storage.
In vitro evaluation of the quality of blood products collected and stored in systems completely free of di(2-ethylhexyl)phthalate-plasticized materials.
New
de Korte et al., Amsterdam, Netherlands. In Transfusion, Mar 2015
With alternative ASs like PAGGS-M, AS-3, or PAGGG-M, the absence of DEHP had no effect on hemolysis.
Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults.
Alzheimer’s Disease Neuroimaging Initiative (ADNI) et al., Indianapolis, United States. In J Alzheimers Dis, 2014
Gene-based meta-analysis identified genome-wide significant associations (ANGPT4 and FAM110A, q-value = 0.026; GRM7-AS3 and LRFN5, q-value = 0.042).
The ctnG gene encodes carbonic anhydrase involved in mycotoxin citrinin biosynthesis from Monascus aurantiacus.
He et al., Nanchang, China. In Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2014
To learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into M. aurantiacus Li AS3.4384 by a protoplast-PEG method.
Enhanced Cellulase Production from Bacillus subtilis by Optimizing Physical Parameters for Bioethanol Production.
Goyal et al., Guwāhāti, India. In Isrn Biotechnol, 2012
Effect of physical parameters such as initial pH, agitation (rpm), and temperature (°C) for cellulase production from Bacillus subtilis AS3 was investigated.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
GeneRIF
Ashworth et al., London, United Kingdom. In Embo J, 2012
Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein.
Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma: an emerging cohesin role in tumor suppression.
GeneRIF
Geck et al., Boston, United States. In Oncogene, 2010
Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma.
Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
GeneRIF
Milbrandt et al., Saint Louis, United States. In Plos One, 2008
While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.
Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells.
GeneRIF
Ionov et al., Buffalo, United States. In Bmc Cancer, 2008
Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells.
Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma.
GeneRIF
Wang et al., Beijing, China. In J Genet Genomics, 2008
The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC.
Spo76p is a conserved chromosome morphogenesis protein that links the mitotic and meiotic programs.
Impact
Zickler et al., Orsay, France. In Cell, 1999
Spo76p is conserved and related to the fungal proteins Pds5p and BIMD and the human AS3 prostate proliferative shutoff-associated protein.
Recent developments in the long-term preservation of red blood cells.
Review
Greenwalt, Cincinnati, United States. In Curr Opin Hematol, 1997
Band 4.1 is important for strengthening the bonds between spectrin and actin in the cytoskeleton.
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