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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

N-acetyltransferase 1

Arylamine N-Acetyltransferase, N-acetyltransferase, p97, NAT1, VCP
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: p97, ATPase, Ubiquitin, CAN, NAT2
Papers using Arylamine N-Acetyltransferase antibodies
Unrestrictive identification of multiple post-translational modifications from tandem mass spectrometry using an error-tolerant algorithm based on an extended sequence tag approach
Srinivasula Srinivasa M., In PLoS ONE, 2007
... polyclonal anti-GAPDH antibody from AbFrontier (Seoul, Korea); Monoclonal anti-Flag antibody (M2) from Sigma (MO, USA); anti-VCP from Fitzgerald Industries (MA, USA), anti-caspase3 ...
Quantitative Cell-based Protein Degradation Assays to Identify and Classify Drugs That Target the Ubiquitin-Proteasome System*
Deshaies Raymond J. et al., In The Journal of Biological Chemistry, 2004
... The antibodies used in this study were anti-GFP (BD Biosciences), anti-luciferase (Promega), and anti-p97 (Research Diagnostics).
Papers on Arylamine N-Acetyltransferase
Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury.
Delibasi et al., Ankara, Turkey. In J Mol Histol, Feb 2016
Furthermore, Jab1/CSN5 expression was gradually upregulated and p97/VCP expression was downregulated in IR injury according to western blotting and immunohistochemistry.
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
Ann et al., Duarte, United States. In Cell Cycle, Feb 2016
In addition, we identify p97 is present in the RNF4-KAP1 interacting complex and the inhibition of p97 renders MCF7 breast cancer cells relatively more sensitive to DNA damage.
The mammalian homologue of yeast AFG1 ATPase (Lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.
Stiburek et al., Praha, Czech Republic. In Biochem J, Feb 2016
Yeast Afg1 was shown to mediate degradation of mitochondrially-encoded complex IV subunits, and based on its similarity with CDC48 (p97/VCP) it was suggested to facilitate extraction of polytopic membrane proteins.
Molecular basis of ALS and FTD: implications for translational studies / Molekularna osnova ALS-a i FTD-a: implikacije za translacijska istraživanja.
Liščić, In Arh Hig Rada Toksikol, Jan 2016
The less frequent TDP-43 pathology in other forms of familial FTD has been linked to a range of mutations in GRN, FUS/TLS, rarely VCP, and other genes.
Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine.
Sauer et al., Cambridge, United States. In J Mol Biol, Jan 2016
UNASSIGNED: The AAA+ Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways.
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
Rolfe et al., Burlingame, United States. In Cancer Cell, Dec 2015
p97 is a AAA-ATPase with multiple cellular functions, one of which is critical regulation of protein homeostasis pathways.
Genetic advances in sporadic inclusion body myositis.
Machado et al., London, United Kingdom. In Curr Opin Rheumatol, Nov 2015
Rare variants in the VCP and SQSTM1 genes have been identified in sIBM patients in two studies using targeted next-generation sequencing and whole-exome sequencing.
Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.
Harper et al., Boston, United States. In Nat Cell Biol, Oct 2015
The AAA-ATPase VCP (also known as p97 or CDC48) uses ATP hydrolysis to 'segregate' ubiquitylated proteins from their binding partners.
Clipping or Extracting: Two Ways to Membrane Protein Degradation.
Lemberg et al., Heidelberg, Germany. In Trends Cell Biol, Oct 2015
While most of our understanding of this mechanism comes from studies on p97/Cdc48-mediated protein dislocation along the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, recent studies have revealed intramembrane proteolysis to be an additional mechanism that can extract transmembrane segments.
Control of p97 function by cofactor binding.
Hänzelmann et al., Würzburg, Germany. In Febs Lett, Oct 2015
p97 (also known as Cdc48, Ter94, and VCP) is an essential, abundant and highly conserved ATPase driving the turnover of ubiquitylated proteins in eukaryotes.
ESCRT-III controls nuclear envelope reformation.
Carlton et al., Bristol, United Kingdom. In Nature, Jul 2015
How annular fusion is accomplished is unknown, but it is thought to involve the p97 AAA-ATPase complex and bears a topological equivalence to the membrane fusion event that occurs during the abscission phase of cytokinesis.
Risks on N-acetyltransferase 2 and bladder cancer: a meta-analysis.
Xu et al., Huangshi, China. In Onco Targets Ther, 2014
BACKGROUND: It is known that bladder cancer disease is closely related to aromatic amine compounds, which could cause cancer by regulating of N-acetylation and N-acetyltransferase 1 and 2 (NAT1 and NAT2).
Sporadic inclusion body myositis: clinical, pathological, and genetic analysis of eight Polish patients.
Kaminska et al., Warsaw, Poland. In Folia Neuropathol, 2014
All twelve patients were screened for the presence of causative mutations in TARDBP, VCP, HNRNPA1, and HNRNPA2B1 genes.
Polyubiquitylation drives replisome disassembly at the termination of DNA replication.
Gambus et al., Birmingham, United Kingdom. In Science, 2014
Here we present evidence consistent with the idea that polyubiquitylation of a replisome component (Mcm7) leads to its disassembly at the converging terminating forks because of the action of the p97/VCP/Cdc48 protein remodeler.
Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication.
Labib et al., Dundee, United Kingdom. In Science, 2014
The Cdc48/p97 segregase then associates with ubiquitylated CMG, leading rapidly to helicase disassembly.
Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.
Boddy et al., Los Angeles, United States. In J Biol Chem, 2012
a new signaling mechanism involving dual recruitment by SUMO and ubiquitin for Cdc48-Ufd1-Npl4 functions in maintaining genome stability.
The Cdc48 protein and its cofactor Vms1 are involved in Cdc13 protein degradation.
Rao et al., San Antonio, United States. In J Biol Chem, 2012
show that both Cdc48 and Vms1, but not Cdc48 cofactors Ufd1 and Ufd2, are crucial for the degradation of Cdc13, a telomere regulator
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.
Goldberg et al., Boston, United States. In Embo J, 2012
p97 restrains post-natal muscle growth, and during atrophy, is essential for the accelerated degradation of most muscle proteins.
[Multilocular Paget's disease in IBMPFD syndrome. A case report with 14-year follow-up].
Prietzel et al., Leipzig, Germany. In Orthopade, 2012
A point mutation in the valosin-containing protein (VCP, p97) gene on chromosome 9p13-p12 consistent with the finding of inclusion body myopathy with early onset Paget's disease and frontotemporal dementia (IBMPFD syndrome).
Variable NAT1 enzyme activity in long-term cultured human HaCaT keratinocytes.
Blömeke et al., Trier, Germany. In J Toxicol Environ Health A, 2011
the activities of the xenobiotic metabolizing phase II enzyme N-acetyltransferase 1 (NAT1) were higher in the late passages compared to the early passages
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