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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2015.

DNA cross-link repair 1C

Artemis, a SCID, MART, phosphoribosylpyrophosphate synthetase, ARTS
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MART-1, CAN, HAD, CD8, V1a
Papers on Artemis
Elements and polycyclic aromatic hydrocarbons in exhaust particles emitted by light-duty vehicles.
New
Querol et al., Aveiro, Portugal. In Environ Sci Pollut Res Int, 02 May 2015
To simulate the real-world driving conditions, three ARTEMIS cycles were followed: road, to simulate a fluid traffic flow and urban with hot and cold starts, to simulate driving conditions in cities.
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining.
New
Zha et al., New York City, United States. In Mol Cell, 02 May 2015
Using a mouse model expressing a kinase-dead (KD) DNA-PKcs protein, we show that ATM-mediated transphosphorylation of DNA-PKcs regulates end-processing at the level of Artemis recruitment, while strict autophosphorylation of DNA-PKcs is necessary to relieve the physical blockage on end-ligation imposed by the DNA-PKcs protein itself.
Macaw palm seed germination is driven by GAs/ABA balance.
New
Garcia et al., Belo Horizonte, Brazil. In Plant Biol (stuttg), 28 Apr 2015
Ex Mart.) seeds as a model.
TLR5 ligand-secreting T cells reshape the tumor microenvironment and enhance antitumor activity.
New
Davila et al., Baltimore, United States. In Cancer Res, 20 Apr 2015
Human T cells engineered to express TLR5L along with DMF5, a T cell receptor that recognizes the melanoma antigen MART-127-35 (DMF5TLR5L T cells), displayed increased proliferation, cytokine production and cytolytic activity against melanoma cells.
Specificity Protein 1 Transcription Factor Regulates Human ARTS Promoter Activity through Multiple Binding Sites.
New
Duan et al., Nantong, China. In Plos One, Dec 2014
There are various splice variants derived from the human Septin4 gene, one of which is ARTS, also known as Septin4_i2.
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.
Review
New
Tainer et al., Berkeley, United States. In Dna Repair (amst), May 2014
X-ray crystal structures, cryo-electron microscopy envelopes, and small angle X-ray scattering (SAXS) solution conformations and assemblies are defining most of the core protein components for NHEJ: Ku70/Ku80 heterodimer; the DNA dependent protein kinase catalytic subunit (DNA-PKcs); the structure-specific endonuclease Artemis along with polynucleotide kinase/phosphatase (PNKP), aprataxin and PNKP related protein (APLF); the scaffolding proteins XRCC4 and XLF (XRCC4-like factor); DNA polymerases, and DNA ligase IV (Lig IV).
Non-homologous end joining often uses microhomology: implications for alternative end joining.
Review
New
Lieber et al., Los Angeles, United States. In Dna Repair (amst), May 2014
Artemis and PALF (also called APLF) appear to be among the primary nucleases involved in non-homologous end joining (NHEJ) and responsible for most nucleolytic end processing in NHEJ.
The clinical impact of deficiency in DNA non-homologous end-joining.
Review
New
Jeggo et al., Newcastle upon Tyne, United Kingdom. In Dna Repair (amst), Apr 2014
Prompted by these findings, a search for radiosensitivity amongst (S)CID patients revealed a radiosensitive sub-class, defined as RS-SCID.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Impact
Chen et al., Princeton, United States. In J Clin Oncol, 2014
High pretreatment NY-ESO-1 and MART-1-specific CD8(+) T cells were associated with progression of disease.
Biomarker discovery and biotherapeutics applications of photosynthetic light-harvesting and bioluminescence light-emitting chromophore-protein complexes in stem cell biology and regenerative medicine.
Review
Koka, In J Stem Cells, 2013
These fluorescence labeled antibodies bound antigens which include those of communicable infectious diseases (HIV/AIDS - env-gp160, gag-p24), non-communicable but also potential hereditary and malignant disorders (Cancer/Tumor Markers - Melan-A/Mart-1 of melanoma), normal immune response cells (Human/Mouse/species cellular MHC/TCR/CD45/CD33/CD56/CD19/CD41), and of types of stem cells (CD34/CD38/c-Mpl/Oct4/Neuropilin-1/SOX17).
Time to HIV-1 RNA suppression below 5 copies/ml during first-line protease inhibitor-based antiretroviral treatment - any impact of residual viremia on treatment success?
Review
Moecklinghoff et al., San Giovanni Rotondo, Italy. In Aids Rev, 2013
In the ARTEMIS trial, 689 antiretroviral treatment-naive patients were randomized to tenofovir/emtricitabine plus either darunavir/ritonavir (n = 343) or lopinavir/ritonavir (n = 346).
Sept4/ARTS regulates stem cell apoptosis and skin regeneration.
Impact
Steller et al., New York City, United States. In Science, 2013
We found that mice deficient for the proapoptotic Sept4/ARTS gene have elevated numbers of hair follicle stem cells (HFSCs) that are protected against apoptosis.
Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells.
Impact
Kawamoto et al., Yokohama, Japan. In Cell Stem Cell, 2013
In this study, we established iPSCs from mature cytotoxic T cells specific for the melanoma epitope MART-1.
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
GeneRIF
Cortes et al., New York City, United States. In J Exp Med, 2012
Point mutations in Artemis that disrupt its interaction with Ligase IV or DNA-PKcs reduce V(D)J recombination.
Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.
GeneRIF
Tansey et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2012
Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.
GeneRIF
de Brouwer et al., Cleveland, United States. In Am J Med Genet A, 2012
missense mutations in PRPS1 can cause a continuous spectrum of features ranging from progressive non-syndromic postlingual hearing impairment to uric acid overproduction, and recurrent infections depending on the functional sites that are affected
Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.
GeneRIF
Legerski et al., Houston, United States. In Cell Cycle, 2012
Regulation of p27 by Artemis and DDB2 is important for cell cycle progression in normally proliferating cells.
Molecular analysis of X-linked inborn errors of purine metabolism: HPRT1 and PRPS1 mutations.
GeneRIF
Fujimori et al., Japan. In Nucleosides Nucleotides Nucleic Acids, 2011
Three HPRT1 mutations in Lesch-Nyhan families were identified but no mutation was identified in any patient in the analysis of PRPS1.
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Impact
Sleckman et al., United States. In Nature, 2011
Although there are several cellular nucleases that could perform this function, only the Artemis nuclease is able to do so efficiently.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Impact
Melief et al., Leiden, Netherlands. In Nat Immunol, 2011
Nardilysin and TOP were required, either together or alone, for the generation of a tumor-specific CTL epitope from PRAME, an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C, and a clinically important epitope from the melanoma protein MART-1.
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