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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 28 May 2015.

DNA cross-link repair 1C

Artemis, a SCID, MART, phosphoribosylpyrophosphate synthetase, ARTS
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins when complexed with protein kinase, DNA-activated, catalytic polypeptide. Mutations in this gene cause Athabascan-type severe combined immunodeficiency (SCIDA). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MART-1, CAN, HAD, CD8, V1a
Papers on Artemis
Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence.
New
Rufer et al., Lausanne, Switzerland. In J Immunol, 22 Jun 2015
In this study, using the novel NTA-His tag-containing multimer technology, we quantified the TCR:pMHC dissociation rates (koff) of tumor-specific vaccine-induced CD8 T cell clones (n = 139) derived from seven melanoma patients vaccinated with IFA, CpG, and the native/EAA or analog/ELA Melan-A(MART-1) 26-35 peptide, binding with low or high affinity to MHC, respectively.
A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
New
Shmookler Reis et al., Little Rock, United States. In Cancer Biol Ther, 21 Jun 2015
In a SCID-rab mouse model mimicking the MM bone marrow microenvironment, treatment with PNArad51_nls ± melphalan significantly suppressed tumor growth after 2 weeks, whereas melphalan plus control PNArad4μ_nls was ineffectual.
Congenital defects in V(D)J recombination.
Review
New
de Villartay, Paris, France. In Br Med Bull, 17 Jun 2015
Two NHEJ factors, Artemis and XLF/Cernunnos, were identified through the molecular studies of SCID patients.
Efficient modeling of range-dependent ray convergence effects in propagation and reverberation.
New
Harrison, La Spezia, Italy. In J Acoust Soc Am, 31 May 2015
Here, by starting with the adiabatic mode sum, the formulation is extended to a slowly varying range-dependent environment and applied to the target-echo and reverberation model, Artemis.
Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog.
New
Kumar et al., Columbus, United States. In Genes Cancer, Mar 2015
In a SCID mouse xenograft model, SAHA significantly enhanced the anti-tumor effects of cisplatin treatment with no added systemic toxicity.
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.
New
Heintz et al., Burlington, United States. In Plos One, Dec 2014
In a SCID mouse xenograft model of human mesothelioma, administration of TS and GV together reduced tumor burden more effectively than either agent alone.
Lentiviral vectors for the treatment of primary immunodeficiencies.
Review
New
Aiuti et al., Roma, Italy. In J Inherit Metab Dis, Jul 2014
In this review, we describe the recent advancements achieved both in vitro and at preclinical level with LVVs for the treatment of Wiskott-Aldrich syndrome (WAS), chronic granulomatous disease (CGD), ADA deficiency (ADA-SCID), Artemis deficiency, RAG1/2 deficiency, X-linked severe combined immunodeficiency (γchain deficiency, SCIDX1), X-linked lymphoproliferative disease (XLP) and immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome.
Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time.
Review
New
Tainer et al., Berkeley, United States. In Dna Repair (amst), May 2014
X-ray crystal structures, cryo-electron microscopy envelopes, and small angle X-ray scattering (SAXS) solution conformations and assemblies are defining most of the core protein components for NHEJ: Ku70/Ku80 heterodimer; the DNA dependent protein kinase catalytic subunit (DNA-PKcs); the structure-specific endonuclease Artemis along with polynucleotide kinase/phosphatase (PNKP), aprataxin and PNKP related protein (APLF); the scaffolding proteins XRCC4 and XLF (XRCC4-like factor); DNA polymerases, and DNA ligase IV (Lig IV).
The clinical impact of deficiency in DNA non-homologous end-joining.
Review
New
Jeggo et al., Newcastle upon Tyne, United Kingdom. In Dna Repair (amst), Apr 2014
Prompted by these findings, a search for radiosensitivity amongst (S)CID patients revealed a radiosensitive sub-class, defined as RS-SCID.
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma.
Impact
Chen et al., Princeton, United States. In J Clin Oncol, 2014
High pretreatment NY-ESO-1 and MART-1-specific CD8(+) T cells were associated with progression of disease.
Biomarker discovery and biotherapeutics applications of photosynthetic light-harvesting and bioluminescence light-emitting chromophore-protein complexes in stem cell biology and regenerative medicine.
Review
Koka, In J Stem Cells, 2013
These fluorescence labeled antibodies bound antigens which include those of communicable infectious diseases (HIV/AIDS - env-gp160, gag-p24), non-communicable but also potential hereditary and malignant disorders (Cancer/Tumor Markers - Melan-A/Mart-1 of melanoma), normal immune response cells (Human/Mouse/species cellular MHC/TCR/CD45/CD33/CD56/CD19/CD41), and of types of stem cells (CD34/CD38/c-Mpl/Oct4/Neuropilin-1/SOX17).
Sept4/ARTS regulates stem cell apoptosis and skin regeneration.
Impact
Steller et al., New York City, United States. In Science, 2013
We found that mice deficient for the proapoptotic Sept4/ARTS gene have elevated numbers of hair follicle stem cells (HFSCs) that are protected against apoptosis.
Regeneration of human tumor antigen-specific T cells from iPSCs derived from mature CD8(+) T cells.
Impact
Kawamoto et al., Yokohama, Japan. In Cell Stem Cell, 2013
In this study, we established iPSCs from mature cytotoxic T cells specific for the melanoma epitope MART-1.
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
GeneRIF
Cortes et al., New York City, United States. In J Exp Med, 2012
Point mutations in Artemis that disrupt its interaction with Ligase IV or DNA-PKcs reduce V(D)J recombination.
Similar temporal and spatial recruitment of native 19S and 20S proteasome subunits to transcriptionally active chromatin.
GeneRIF
Tansey et al., Nashville, United States. In Proc Natl Acad Sci U S A, 2012
Data show that proteasome subunits Rpt1, Rpt4, Rpn8, Rpn12, Pre6, and Pre10 are recruited to GAL10 rapidly upon galactose induction.
Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.
GeneRIF
de Brouwer et al., Cleveland, United States. In Am J Med Genet A, 2012
missense mutations in PRPS1 can cause a continuous spectrum of features ranging from progressive non-syndromic postlingual hearing impairment to uric acid overproduction, and recurrent infections depending on the functional sites that are affected
Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27.
GeneRIF
Legerski et al., Houston, United States. In Cell Cycle, 2012
Regulation of p27 by Artemis and DDB2 is important for cell cycle progression in normally proliferating cells.
Molecular analysis of X-linked inborn errors of purine metabolism: HPRT1 and PRPS1 mutations.
GeneRIF
Fujimori et al., Japan. In Nucleosides Nucleotides Nucleic Acids, 2011
Three HPRT1 mutations in Lesch-Nyhan families were identified but no mutation was identified in any patient in the analysis of PRPS1.
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Impact
Sleckman et al., United States. In Nature, 2011
Although there are several cellular nucleases that could perform this function, only the Artemis nuclease is able to do so efficiently.
Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes.
Impact
Melief et al., Leiden, Netherlands. In Nat Immunol, 2011
Nardilysin and TOP were required, either together or alone, for the generation of a tumor-specific CTL epitope from PRAME, an immunodominant CTL epitope from Epstein-Barr virus protein EBNA3C, and a clinically important epitope from the melanoma protein MART-1.
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