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Actin related protein 2/3 complex, subunit 5, 16kDa

ARPC5, p16-Arc, actin-related protein 2/3 complex subunit 5,
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Arp2, Actin-Related Protein 3, ARPC2, ARPC4
Papers using ARPC5 antibodies
The microtubule-binding protein CLIP-170 coordinates mDia1 and actin reorganization during CR3-mediated phagocytosis
Niedergang Florence et al., In The Journal of Cell Biology, 2003
... Erasmus University); anti–α-tubulin (DM1A; Sigma-Aldrich); anti-myc (Roche); anti-mDia1, anti-EB1, anti-CLIP-115, and anti-clathrin heavy chain (BD); anti–p16-Arc (Synaptic Systems GmbH); anti-GST (home made); ...
Papers on ARPC5
Isoform diversity in the Arp2/3 complex determines actin filament dynamics.
Way et al., Gif-sur-Yvette, France. In Nat Cell Biol, Jan 2016
In mammals, however, the ARPC1 and ARPC5 subunits are each encoded by two isoforms that are 67% identical.
Spectrin alpha is important for rear polarization of the microtubule organizing center during migration and spindle pole assembly during division of neointimal smooth muscle cells.
Bendeck et al., Toronto, Canada. In Cytoskeleton (hoboken), Apr 2015
We showed previously that two cytoskeleton-associated proteins, RHAMM and ARPC5, play important roles in rear polarization of the microtubule organizing centre (MTOC), directed migration, and in maintaining cell division fidelity.
Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.
Macaluso et al., Baton Rouge, United States. In Plos One, 2013
To investigate the role of the tick Arp2/3 complex in tick-Rickettsia interactions, open reading frames of all subunits of the protein including Arp2, Arp3, ARPC1, ARPC2, ARPC3, ARPC4, and ARPC5 were identified from Dermacentor variabilis.
Effects of hypothyroidism on expression of CRMP2B and ARPC5 during development of the rat frontal cortex.
Yu et al., Tianjin, China. In Int J Biol Sci, 2012
ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development.
Actin-related protein 2/3 complex subunit 5 (ARPC5) contributes to cell migration and invasion and is directly regulated by tumor-suppressive microRNA-133a in head and neck squamous cell carcinoma.
Seki et al., Chiba, Japan. In Int J Oncol, 2012
Levels of ARPC5 expression were significantly higher in invasive cancer cells and gene expression was directly regulated by miR-133a.
Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
Park et al., Seoul, South Korea. In Cell Mol Biol Lett, 2012
In particular, eukaryotic translation initiation factor 3 subunit 1, nucleophosmin, latexin, actin-related protein 2/3 complex subunit 5, M2-type pyruvate kinase, vimentin, tumor protein translationally-controlled 1, RAS oncogene family Ran, plastin 3 precursor, ATPase, Rho GDT dissociation inhibitor β, and proteasome activator subunit 2 expression were quantitatively up-regulated.
Tumor suppressive microRNA-133a regulates novel molecular networks in lung squamous cell carcinoma.
Seki et al., Chiba, Japan. In J Hum Genet, 2012
Gene expression data and web-based searching revealed several candidate genes, including transgelin 2 (TAGLN2), actin-related protein2/3 complex, subunit 5, 16kDa (ARPC5), LAG1 homolog, ceramide synthase 2 (LASS2) and glutathione S-transferase pi 1 (GSTP1).
Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.
Bendeck et al., Toronto, Canada. In Am J Pathol, 2011
Using phosphoproteomic screening and mass spectrometry, we identified ARPC5 and RHAMM as protein kinase C (PKC)-phosphorylated proteins associated with rear polarization of the MTOC in neointimal SMCs.
The essential role of clathrin-mediated endocytosis in the infectious entry of human enterovirus 71.
Chu et al., Singapore, Singapore. In J Biol Chem, 2011
The infectious entry of HEV71 into rhabdomyosarcoma cells was shown to be significantly inhibited by siRNAs targeting genes associated with clathrin-mediated endocytosis (CME) that include AP2A1, ARRB1, CLTC, CLTCL1, SYNJ1, ARPC5, PAK1, ROCK1, and WASF1.
Molecular dynamics simulations of Arp2/3 complex activation.
Pollard et al., New Haven, United States. In Biophys J, 2010
When we applied forces to Arp2 while restraining Arp3, one block of structure (Arp2, subunit ARPC1, the globular domain of ARPC4 and ARPC5) rotated counterclockwise by 30° around a pivot point in an α-helix of ARPC4 (Glu⁸¹-Asn¹⁰⁰) to align Arp2 next to Arp3 in a second block of structure including ARPC3 and the globular domains of ARPC2.
The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation.
Goode et al., Waltham, United States. In J Biol Chem, 2010
We identified three distinct sites on p40/ARPC1 required for function in vivo: one site contacts p19/ARPC4, one contacts p15/ARPC5, and one site resides in an extended structural "arm" of p40/ARPC1.
Nucleotide- and activator-dependent structural and dynamic changes of arp2/3 complex monitored by hydrogen/deuterium exchange and mass spectrometry.
Almo et al., United States. In J Mol Biol, 2009
Changes in the rate of hydrogen exchange indicate that ATP binding causes conformational rearrangements of Arp2 and Arp3 that are transmitted allosterically to the Arp complex (ARPC)1, ARPC2, ARPC4, and ARPC5 subunits.
Structure and biochemical properties of fission yeast Arp2/3 complex lacking the Arp2 subunit.
Pollard et al., New Haven, United States. In J Biol Chem, 2008
Truncation of the N terminus of ARPC5, the smallest subunit in the complex, increased the yield of Arp2Delta Arp2/3 complex during purification but did not compromise nucleation activity of the full Arp2/3 complex.
Expression profiling suggests a regulatory role of gallbladder in lipid homeostasis.
Zhang et al., Shanghai, China. In World J Gastroenterol, 2005
ARPC5 (2 225.88+/-90.46),
Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis.
McLeish et al., Louisville, United States. In J Biol Chem, 2003
identified as a substrate of MAPK-activated protein kinase 2(MAPKAPK2); the ability of MAPKAPK2 to phosphorylate one isoform of p16-Arc suggests a possible mechanism by which the p38 MAPK cascade regulates remodeling of the actin cytoskeleton
Crystal structure of Arp2/3 complex.
Pollard et al., Los Angeles, United States. In Science, 2001
ARPC3 p21 and ARPC5 p16 are globular alpha-helical subunits.
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