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Actin related protein 2/3 complex, subunit 2, 34kDa

ARPC2, p34-Arc, actin-related protein 2/3 complex subunit 2
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Actin, Arp2, ARPC4, ARPC5, Actin-Related Protein 3
Papers on ARPC2
Arp2/3 complex subunit ARPC2 binds to microtubules.
New
Schwarzerová et al., Praha, Czech Republic. In Plant Sci, Dec 2015
Here we show that ARPC2, a core Arp2/3 complex subunit, interacts with both actin filaments (AFs) and microtubules (MTs).
Tumor promotion by γ and suppression by β non-muscle actin isoforms.
New
Kopnin et al., Moscow, Russia. In Oncotarget, Jul 2015
In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other regulatory proteins.
Identification of metastasis-suppressive microRNAs in primary melanoma.
New
Hernando et al., British Indian Ocean Territory. In J Natl Cancer Inst, Mar 2015
Moreover, we identified actin regulators CTTN, RAC1, and ARPC2 as direct targets of miR-382.
iTRAQ-based proteomic identification of proteins involved in anti-angiogenic effects of Panduratin A on HUVECs.
New
Mustafa et al., Kuala Lumpur, Malaysia. In Phytomedicine, Feb 2015
PA inhibited the expressions of ARPC2 and CTNND1 that are associated with the formation of actin cytoskeleton, focal adhesion and cellular protrusions.
Forkhead Box F1 represses cell growth and inhibits COL1 and ARPC2 expression in lung fibroblasts in vitro.
Plantier et al., Paris, France. In Am J Physiol Lung Cell Mol Physiol, 2015
In normal lung fibroblasts, FOXF1 repressed cell growth and expression of collagen-1 (COL1) and actin-related protein 2/3 complex, subunit 2 (ARPC2).
ARP2/3 complex is required for directional migration of neural stem cell-derived oligodendrocyte precursors in electric fields.
Yao et al., Wichita, United States. In Stem Cell Res Ther, 2014
METHODS: NSCs were isolated from the brains of ARPC2+/+ and ARPC2-/- mouse embryo and differentiated into OPCs.
Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs.
Plastow et al., Edmonton, Canada. In Bmc Genet, 2014
Four of them are intragenic with ARPC2, TMBIM1, NRAMP1 and VIL1, while the remaining two are close to RUFY4 and CDK5R2.
Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study.
Hahn et al., Hannover, Germany. In Lipids Health Dis, 2014
RESULTS: N-3 PUFA supplementation resulted in a significant down-regulation of cytoskeleton-associated genes, in particular three GTPases (RAC1, RHOA, CDC42), three kinases (ROCK1, PAK2, LIMK), two Wiskott-Aldrich syndrome proteins (WASL, WASF2) as well as actin related protein 2/3 complex (ARPC2, ARPC3) and cofilin (CFL1).
Identification and characterization of RNA guanine-quadruplex binding proteins.
Kurreck et al., Berlin, Germany. In Nucleic Acids Res, 2014
In the present study, we investigate the interaction between cellular proteins and the G-quadruplexes located in two mRNAs (MMP16 and ARPC2).
Transcriptional profiling of erythroid progenitors from G-CSF mobilized and nonmobilized peripheral blood.
Jovcic et al., Belgrade, Serbia. In J Buon, 2014
The most significant genes in mPB-derived erythroid progenitors were P4HB, DDIA3, ARPC2 and ATP5G3.
Pair-wise comparison analysis of differential expression of mRNAs in early and advanced stage primary colorectal adenocarcinomas.
Chua et al., Kuala Lumpur, Malaysia. In Bmj Open, 2013
However, the ARPC2 gene was significantly underexpressed in early colorectal adenocarcinomas, while the advanced stage primary colorectal tumours exhibited an additional overexpression of the C6orf173 gene (p<0.05).
Novel identification of Dermacentor variabilis Arp2/3 complex and its role in rickettsial infection of the arthropod vector.
Macaluso et al., Baton Rouge, United States. In Plos One, 2013
To investigate the role of the tick Arp2/3 complex in tick-Rickettsia interactions, open reading frames of all subunits of the protein including Arp2, Arp3, ARPC1, ARPC2, ARPC3, ARPC4, and ARPC5 were identified from Dermacentor variabilis.
Proteomic analysis identifies an NADPH oxidase 1 (Nox1)-mediated role for actin-related protein 2/3 complex subunit 2 (ARPC2) in promoting smooth muscle cell migration.
Csányi et al., Pittsburgh, United States. In Int J Mol Sci, 2012
Among these proteins, actin-related protein 2/3 complex subunit 2 (ARPC2) with no previous link to Nox isozymes, H2O2, or other reactive oxygen species (ROS), was identified and postulated to play an intermediary role in VSMC migration.
Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway.
GeneRIF
Welch et al., Berkeley, United States. In Cell Microbiol, 2012
The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
Filopodia initiation: focus on the Arp2/3 complex and formins.
GeneRIF
Svitkina et al., Philadelphia, United States. In Cell Adh Migr, 2011
Filopodia initiation: focus on the Arp2/3 complex and formins
Nogo-B regulates migration and contraction of airway smooth muscle cells by decreasing ARPC 2/3 and increasing MYL-9 expression.
GeneRIF
Li et al., Shanghai, China. In Respir Res, 2010
Endogenous Nogo-B, which may exert its effects through ARPC 2/3 and MYL-9, is necessary for the migration and contraction of airway smooth muscle cells.
Revolving movement of a dynamic cluster of actin filaments during mitosis.
GeneRIF
Nishida et al., Kyoto, Japan. In J Cell Biol, 2010
The results identify Arp2/3 complex as a key factor in the generation of the dynamic actin cluster during mitosis.
Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
GeneRIF
Klip et al., Toronto, Canada. In Mol Biol Cell, 2010
Arp2/3 and cofilin coordinate a dynamic cycle of actin branching and severing at the cell cortex, essential for insulin-mediated GLUT4 translocation in muscle cells.
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
Impact
GeneRIF
Schreiber et al., Kiel, Germany. In Nat Genet, 2008
These findings strongly suggest that defective IL10 function is central to the pathogenesis of the ulcerative colitis subtype of inflammatory bowel disease.
Crystal structure of Arp2/3 complex.
Impact
Pollard et al., Los Angeles, United States. In Science, 2001
Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains.
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