Effect of omega-3 polyunsaturated fatty acids on the cytoskeleton: an open-label intervention study.
Hannover, Germany. In Lipids Health Dis, 2014
RESULTS: N-3 PUFA supplementation resulted in a significant down-regulation of cytoskeleton-associated genes, in particular three GTPases (RAC1, RHOA, CDC42), three kinases (ROCK1, PAK2, LIMK), two Wiskott-Aldrich syndrome proteins (WASL, WASF2) as well as actin related protein 2/3 complex (ARPC2, ARPC3) and cofilin (CFL1).
Crystal structure of Arp2/3 complex.
Los Angeles, United States. In Science, 2001
Subunits ARPC2 p34 and ARPC4 p20 in the core of the complex associate through long carboxyl-terminal alpha helices and have similarly folded amino-terminal alpha/beta domains.